Cited by 2223D Printing in Biomedical ResearchPluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

Wang, Yaqing, Wang, Hui, Deng, Pengwei, Chen, Wenwen, Guo, Yaqiong, Tao, Tingting, Qin, Jianhua·2018·Lab on a Chip

Abstract

We present a new strategy to engineer human iPSC-derived liver organoids by combining stem cell biology with a microfluidic chip system.

Integrity signals

Registry

Crossref · 10.1039/c8lc00869h

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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  • Droplet-based microfluidics enabled better scRNA-seq analysis of intestinal organoid cell identities during developmental stages, revealing extensive population heterogeneity.

    “authors use droplet-based microfluidics to perform better scRNA-seq analysis of intestinal organoid cell identities during various developmental stages, revealing extensive population heterogeneity76.”

    From Organoids (2022) · cites this paper as [76]

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Authors
Wang, Y., Wang, H., Deng, P., Chen, W., Guo, Y., Tao, T., & Qin, J.
Affiliations
Dalian Institute of Chemical Physics (CN)
Corresponding author
Qin, Jianhua
Venue
Lab on a Chip
Published
2018
Volume
18
Issue
23
Pages
3606-3616
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2896011625
Cited by
222
References
39
Citations by year
2026: 22 · 2025: 28 · 2024: 35 · 2023: 27 · 2022: 36 · 2021: 34 · 2020: 24 · 2019: 15 · 2014: 1
FWCI
7.29
Type
journal article
Language
en
Open access
closed
Locations
  • Lab on a Chip (publishedVersion)
  • PubMed (publishedVersion)
  • Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
Funders
  • Chinese Academy of Sciences (XDA16020900, XDPB0305)
  • National Natural Science Foundation of China (91543121, 31671038, 81573394, 31600784)
  • Dalian Institute of Chemical Physics (DICP TMSR201601)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
liver organoids, human induced pluripotent stem cells, embryoid bodies, hepatocyte differentiation, cholangiocyte differentiation, acetaminophen hepatotoxicity, drug testing, liver disease modeling, regenerative medicine
MeSH terms
Cell Differentiation, Cell Survival, Equipment Design, Humans, Liver, Organoids, Perfusion, Tissue Array Analysis, Hepatocyte Nuclear Factor 3-beta, SOXF Transcription Factors, Induced Pluripotent Stem Cells

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