Engineering human islet organoids from iPSCs using an organ-on-chip platform
Abstract
This work presents a new strategy to engineer functional human islet organoids from iPSCs in a perfusable organ-on-a-chip device.
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A two-organoid microfluidic device was fabricated with multiple readouts using cardiac and hepatic organoids.
“A two-organoid microfluidic device was recently fabricated with multiple readouts using cardiac and hepatic organoids103.”
From Organoids (2022) · cites this paper as [103]
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- Authors
- Tao, T., Wang, Y., Chen, W., Li, Z., Su, W., Guo, Y., Deng, P., & Qin, J.
- Affiliations
- Dalian Institute of Chemical Physics (CN)
- Corresponding author
- Qin, Jianhua
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 19
- Issue
- 6
- Pages
- 948-958
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2913901728
- Cited by
- 198
- References
- 39
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 22 · 2023: 29 · 2022: 39 · 2021: 30 · 2020: 28 · 2019: 8
- FWCI
- 25.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
- Funders
- China Postdoctoral Science Foundation (2018M631836)
- National Natural Science Foundation of China (91543121, 81573394, 81803492)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- induced pluripotent stem cells, organ-on-a-chip, microfluidics, beta cell differentiation, glucose-stimulated insulin secretion, calcium flux, PDX1, NKX6.1, C-peptide, diabetes modeling, regenerative medicine, drug screening
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