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Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
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Hepatocyte proliferation is the principal mechanism for generating new hepatocytes in liver homeostasis and regeneration. Recent studies have suggested that this ability is not equally distributed among hepatocytes but concentrated in a small subset of hepatocytes acting like stem cells, located around the central vein or distributed throughout the liver lobule and exhibiting active WNT signaling or high telomerase activity, respectively. These findings were obtained by utilizing components of these growth regulators as markers for genetic lineage tracing. Here, we used random lineage tracing to localize and quantify clonal expansion of hepatocytes in normal and injured liver. We found that modest proliferation of hepatocytes distributed throughout the lobule maintains the hepatocyte mass and that most hepatocytes proliferate to regenerate it, with diploidy providing a growth advantage over polyploidy. These results show that the ability to proliferate is broadly distributed among hepatocytes rather than limited to a rare stem cell-like population.
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“Nevertheless, hepatocytes do not proliferate equally over time, as results obtained via three independent experimental approaches have led to the same conclusion, namely that zone 2 hepatocytes proliferate more than hepatocytes from the other zones.75,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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“Additionally, injury to zone 1 by allyl alcohol injection or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet was compensated by proliferation of hepatocytes in zones 2 and 3.85,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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“recent studies have demonstrated that hepatocytes are primarily maintained by the proliferation of pre-existing hepatocytes during liver homeostasis and regeneration14–19”
From Multimodal decoding of human liver regeneration (2024) · cites this paper as [14]
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“During homeostasis, zone 2 hepatocytes rather than a defined subpopulation seem to have increased proliferative potential.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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“3D imaging of labelled cells and their progeny showed that hepatocyte renewal is not driven by zone 3, no hepatocytes formed particularly large clones, and hepatocyte proliferation was distributed throughout the lobule with larger hepatocyte clones more frequently found in zone 2.88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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“Zone 2 hepatocytes labelled by AAV8-TBG-Cre or CreERT2 expressed from the Hamp2 or Mup3 promoters also proliferated and clonally expanded.86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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“However, ∼80% of hepatocytes randomly labelled by AAV8-TBG-Cre gave rise to expanding hepatocyte clones in mouse livers subjected to repeated CCl4 injury, indicating that proliferative hepatocytes are relatively abundant.88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [88]
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Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging
Susaki, E. A., Tainaka, K., Perrin, D., Yukinaga, H., Kuno, A., & Ueda, H. R. (2015) · Nature Protocols · doi:10.1038/nprot.2015.085 · Cited by 822
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674
Coronary arteries form by developmental reprogramming of venous cells
Red‐Horse, K., Ueno, H., Weissman, I. L., & Krasnow, M. A. (2010) · Nature · doi:10.1038/nature08873 · Cited by 550
The ploidy conveyor of mature hepatocytes as a source of genetic variation
Duncan, A. W., Taylor, M. H., Hickey, R. D., Hanlon Newell, A. E., Lenzi, M. L., Olson, S. B., Finegold, M. J., & Grompe, M. (2010) · Nature · doi:10.1038/nature09414 · Cited by 525
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Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486
Luche, H., Weber, O., Nageswara Rao, T., Blum, C., & Fehling, H. J. (2007) · European Journal of Immunology · doi:10.1002/eji.200636745 · Cited by 482
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461
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Yanger, K., Knigin, D., Zong, Y., Maggs, L., Gu, G., Akiyama, H., Pikarsky, E., & Stanger, B. Z. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.003 · Cited by 426
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Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425
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Ma, R., Martínez-Ramírez, A. S., Borders, T. L., Gao, F., & Sosa-Pineda, B. (2020) · eLife · doi:10.7554/elife.46206 · Cited by 97
Zhang, L., Ma, X.-J.-N., Fei, Y.-Y., Han, H., Xu, J., Cheng, L., & Li, X. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108004 · Cited by 95
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Beumer, J., & Clevers, H. C. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.006 · Cited by 92
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Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.013 · Cited by 84
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Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., Feddema, J., Welsch, T., Alkass, K., Salehpour, M., et al. (2022) · Cell Systems · doi:10.1016/j.cels.2022.05.001 · Cited by 73
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Brown, J. W., Cho, C. J., & Mills, J. C. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061121-035954 · Cited by 68
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Liu, M., Huang, Q., Zhu, Y., Chen, L., Li, Y., Gong, Z., & Ai, K. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100215 · Cited by 70
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Zhou, L., Yu, K. H., Wong, T. L., Zhang, Z., Chan, C. H., Loong, J. H. C., Che, N., Yu, H., Tan, K. V., Tong, M., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324321 · Cited by 64
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Self-citationJin, Y., Zhang, J., Xu, Y., Yi, K., Li, F., Zhou, H., Wang, H., Chan, H. F., Lao, Y.-H., Lv, S., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.001 · Cited by 55
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Sun, L., & Hui, L. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa013 · Cited by 57
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Lin, H., Huang, Y., Fustin, J., Doi, M., Chen, H., Lai, H., Lin, S., Lee, Y.-L., King, P.-C., Hou, H.-S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20572-8 · Cited by 53
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Ruz‐Maldonado, I., González, J. T., Zhang, H., Sun, J., Bort, A., Kabir, I., Kibbey, R. G., Suárez, Y., Greif, D. M., & Fernandez-Hernando, C. F. (2024) · Nature Communications · doi:10.1038/s41467-024-45439-0 · Cited by 26
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Pek, N. M. Q., Liu, K. J., Nichane, M., & Ang, L. T. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.09.016 · Cited by 25
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He, J., Deng, C., Krall, L., & Shan, Z. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00152-5 · Cited by 18
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Guo, P.-C., 吉林大学动物医学学院人兽共患病研究所人兽共患病研究教育部重点实验室, 人., Zuo, J., Huang, K.-K., Lai, G., Zhang, X., An, J., Li, J., Li, L., Wu, L. L., et al. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.031 · Cited by 19
Regulation of chromatin organization during animal regeneration
Jia, X., Lin, W., & Wang, W. (2023) · Cell Regeneration · doi:10.1186/s13619-023-00162-x · Cited by 18
Bao, Z., Guo, C., Chen, Y., Li, C., Lei, T., Zhou, S., Qi, D., & Xiang, Z. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112718 · Cited by 17
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Porat‐Shliom, N. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102292 · Cited by 16
Relationships Between Regeneration, Wound Healing, and Cancer
Maggiore, G., & Zhu, H. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-062822-123558 · Cited by 18
Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases
Safarikia, S., Carpino, G., Overi, D., Cardinale, V., Venere, R., Franchitto, A., Onori, P., Alvaro, D., & Gaudio, E. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00479 · Cited by 16
Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish
Zhang, W., Chen, J., Ni, R., Yang, Q., Luo, L., & He, J. (2021) · iScience · doi:10.1016/j.isci.2021.102142 · Cited by 15
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Li, J., Wang, S., Yuan, J., Mao, X., Wang, X., Zhang, L., Dong, Q., Chen, Z., Wang, Y., & Tang, N. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.002 · Cited by 19
Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing
He, S., Guo, Z., Zhou, M., Wang, H., Zhang, Z., Shi, M., Li, X., Yang, X., & He, L. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.002 · Cited by 17
Microscale tissue engineering of liver lobule models: advancements and applications
Wang, Q., Liu, J., Yin, W., Wang, A., Zheng, J., Wang, Y., & Dong, J. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1303053 · Cited by 17
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase
Darmasaputra, G., Geerlings, C. C., Lopes, S. M. C. D. S., Clevers, H. C., & Galli, M. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202403020 · Cited by 16
Kim, K., & Lee, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010566 · Cited by 14
Bio inspired heuristic computing scheme for the human liver nonlinear model
Sabir, Z., Saïd, S. B., & Al‐Mdallal, Q. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28912 · Cited by 14
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation
Koopmans, T., & van Rooij, E. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01145-y · Cited by 14
Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells
Saxena, M., & Shivdasani, R. A. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034520 · Cited by 14
Sato, Y., Yoneda, A., Shimizu, F., Nishimura, M., Shimoyama, R., Tashiro, Y., Kurata, W., & Niitsu, Y. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15587 · Cited by 14
Wiszniewski, G., Jarmołowicz, S., hassaan, M. S., Kamaszewski, M., Szudrowicz, H., Terech-Majewska, E., Kawalski, K., Martynow, J., Szczepański, A., & Siwicki, A. K. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101196 · Cited by 13
Jiang, M., Guo, R., Ai, Y., Wang, G., Tang, P., Jia, X., He, B., Yuan, Q., & Xie, X. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100670 · Cited by 13
Passman, A. M., Haughey, M. J., Carlotti, E., Williams, M. J., Cereser, B., Lin, M., Devkumar, S., Gabriel, J. P., Gringeri, E., Cillo, U., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.044 · Cited by 12
Li, Y., Li, M., Duan, S., Zhang, S., Lu, H., Guo, X., & Zhong, K. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116817 · Cited by 13
Metadata
- Authors
- Chen, F., Jimenez, R. J., Sharma, K., Luu, H. Y., Hsu, B. Y., Ravindranathan, A., Stohr, B. A., & Willenbring, H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Chen, Feng
- Willenbring, Holger
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 26
- Issue
- 1
- Pages
- 27-33.e4
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC8009755
- OpenAlex
- W2996029077
- Cited by
- 236
- References
- 21
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 34 · 2023: 51 · 2022: 34 · 2021: 44 · 2020: 26
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Eli and Edythe Broad Foundation (R01 AA026578, CIRM DISC2-10088)
- California Institute of Regenerative Medicine
- National Institutes of Health (P30 DK026743, R01 AA026578, T32 DK060414)
- Novartis
- Jane Coffin Childs Memorial Fund for Medical Research
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hepatocyte proliferation, liver homeostasis, liver regeneration, clonal expansion, Wnt signaling, telomerase, polyploidy, diploidy, liver lobule
- MeSH terms
- Homeostasis, Liver, Liver Regeneration, Hepatocytes, Cell Proliferation
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