Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver
Open accessPublished version of a preprint
Abstract
The adult liver has an exceptional ability to regenerate, but how it maintains its specialized functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in tandem with single-cell transcriptomics to track cellular transitions and heterogeneities of ∼22,000 liver cells through the initiation, progression, and termination phases of mouse liver regeneration. Our results uncovered that, following PHx, a subset of hepatocytes transiently reactivates an early-postnatal-like gene expression program to proliferate, while a distinct population of metabolically hyperactive cells appears to compensate for any temporary deficits in liver function. Cumulative EdU labeling and immunostaining of metabolic, portal, and central vein–specific markers revealed that hepatocyte proliferation after PHx initiates in the midlobular region before proceeding toward the periportal and pericentral areas. We further demonstrate that portal and central vein proximal hepatocytes retain their metabolically active state to preserve essential liver functions while midlobular cells proliferate nearby. Through combined analysis of gene regulatory networks and cell–cell interaction maps, we found that regenerating hepatocytes redeploy key developmental regulons, which are guided by extensive ligand-receptor-mediated signaling events between hepatocytes and nonparenchymal cells. Altogether, our study offers a detailed blueprint of the intercellular crosstalk and cellular reprogramming that balances the metabolic and proliferative requirements of a regenerating liver.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous changes in mRNA abundance and splicing occur within the first 3 weeks of life, as hematopoiesis and proliferative activity are reduced, and gene products involved in metabolism are induced.
“Numerous changes in mRNA abundance and splicing occur within the first 3 weeks of life (Bhate et al. 2015; Chembazhi et al. 2021; Liang et al. 2022), as hematopoiesis and proliferative activity are reduced, and gene products involved in metabolism are induced (Zaret 2002; Gordillo et al. 2015).”
From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Chembazhi et al. 2021
The Results section on postnatal maturation reports changes in gene expression between P14 and adult hepatocytes, supporting the mRNA-abundance portion of the cited clause. It does not establish that these changes occurred within the first three weeks of life. The Discussion describes measuring splicing within single cells as future work, rather than reporting postnatal splicing changes. The later clause about hematopoiesis and metabolism is attributed to other citations in the citing sentence. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSeveral studies suggest that hepatocyte proliferation leads to metabolic remodelling and that hepatocytes across the liver can adapt dynamically to changes during regeneration.
“Several studies suggest that hepatocyte proliferation leads to metabolic remodelling and that hepatocytes across the liver can adapt dynamically to changes during regeneration106,107,[131], [132], [133], [134], [135]”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [106]
The Results (Cell type composition, heterogeneity, and metabolic dynamics) describe transient changes in metabolic pathways alongside increased proliferation-related activity after partial hepatectomy. The Discussion describes dynamic hepatocyte states in different liver regions. The paper does not establish that proliferation itself causes the metabolic remodelling; it presents both as coordinated responses during regeneration. (LLM, conf=0.84)
Experimental — accuracy not yet measuredDuring pan-zonal regeneration induced by partial hepatectomy, hepatocytes across the liver underwent transient fetal reprogramming to acquire proliferative potential.
“During pan-zonal regeneration induced by partial hepatectomy, hepatocytes across the liver underwent transient fetal reprogramming to acquire proliferative potential.106,107”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [106]
The Abstract and Discussion report that, after partial hepatectomy, a subset of hepatocytes reversibly activates an early-postnatal-like program and enters a proliferative state. They do not describe fetal reprogramming across the liver: proliferation begins in the midlobular region, while distinct hepatocytes near the portal and central veins maintain metabolic activity. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTransient changes in hepatocyte identity are required when hepatocytes re-enter the cell cycle in response to injury, while others increase metabolic function to maintain hepatic metabolism.
“Transient changes in hepatocyte identity are required when hepatocytes re-enter the cell cycle in response to injury, while others increase metabolic function to maintain hepatic metabolism.25,104,106,107,134”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [106]
The Discussion (page not available) reports transient changes in hepatocyte gene programs before cell-cycle entry after partial hepatectomy, while other hepatocytes enter a metabolically hyperactive state. The Results, “Division of labor balances the proliferation and metabolic demands of a regenerating liver” (page not available), reports increased metabolic-gene expression in that subset. The paper does not establish that these identity changes are required across liver injuries generally; it studies partial hepatectomy and says whether the pattern occurs in other injury models remains unknown. (LLM, conf=0.86)
Experimental — accuracy not yet measuredscRNA-seq analysis identified four hepatocyte states after PHx: quiescent (5328), transition (5137), proliferating (6769), and hypermetabolic (1038) among 18,272 hepatocytes.
“Importantly, single-cell transcriptomic analysis identified distinct clusters among 18,272 hepatocytes corresponding to quiescent (5328 hepatocytes), transition (5137 hepatocytes), proliferating (6769 hepatocytes), and hypermetabolic (1038 hepatocytes) states after PHx.6”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [6]
The Results sections on cell-type composition and division of labor report 18,272 hepatocytes and classify them into the four named states. Our copy does not give the claimed count for each state (5,328; 5,137; 6,769; and 1,038). The 18,272 cells also include samples from uninjured adult and postnatal livers, not only samples collected after PHx. (LLM, conf=0.87)
Experimental — accuracy not yet measured
CAR coordinates metabolic adaptation, particularly by constraining BA homeostasis, and is important for hypermetabolic hepatocytes, which support regeneration by meeting increased metabolic demands.
“Taken together, our data indicate that CAR coordinates metabolic adaptation, particularly by constraining BA homeostasis, and is an important factor for the hypermetabolic hepatocytes, which support regeneration by meeting increased metabolic demands.6”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [6]
The Results section, “Division of labor balances the proliferation and metabolic demands of a regenerating liver” (page unavailable), supports the point that metabolically hyperactive hepatocytes help counteract regeneration-associated deficits in liver function. The cited paper does not establish the attributed role of CAR in coordinating metabolic adaptation or constraining bile-acid homeostasis; the citing sentence presents that as its authors’ own conclusion. (LLM, conf=0.84)
Experimental — accuracy not yet measuredFollowing partial hepatectomy, a subset of hepatocytes transiently acquired an early-postnatal-like gene expression programme to proliferate, while other hepatocytes became metabolically hyperactive to compensate for temporary deficits in liver function.
“Following partial hepatectomy, a subset of hepatocytes transiently acquired an early-postnatal-like gene expression programme to proliferate, while other hepatocytes became metabolically hyperactive to compensate for any temporary deficits in liver function.106”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [106]
A subset of hypermetabolic hepatocytes compensates for the transient loss of metabolic function during liver regeneration after PHx.
“A recent single-cell study characterized the functional heterogeneity within hepatocytes after PHx and identified a subset of hypermetabolic hepatocytes that compensate for the transient loss of metabolic function during regeneration.6”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488 · see citing works
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353 · see citing works
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314 · see citing works
Scenic: single-cell regulatory network inference and clustering.
Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520 · see citing works
Reversed graph embedding resolves complex single-cell trajectories
Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070 · see citing works
Burden of liver diseases in the world
Asrani, S. K., Devarbhavi, H., Eaton, J., & Kamath, P. S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.09.014 · Cited by 3,783 · see citing works
Organoid Models and Applications in Biomedical Research
Xinaris, C., Brizi, V., & Remuzzi, G. (2015) · The Nephron journals/Nephron journals · doi:10.1159/000433566 · Cited by 3,517 · see citing works
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
Street, K., Risso, D., Fletcher, R. B., Das, D., Ngai, J., Yosef, N., Purdom, E., & Dudoit, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4772-0 · Cited by 3,159 · see citing works
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828 · see citing works
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Haghverdi, L., Lun, A. T. L., Morgan, M. D., & Marioni, J. C. (2018) · Nature Biotechnology · doi:10.1038/nbt.4091 · Cited by 2,416 · see citing works
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358 · see citing works
Single-cell mRNA quantification and differential analysis with Census
Qiu, X., Hill, A. J., Packer, J. S., Lin, D., Ma, Y.-A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4150 · Cited by 1,885 · see citing works
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion
van Dijk, D., Sharma, R., Nainys, J., Yim, K., Kathail, P., Carr, A. J., Burdziak, C., Moon, K. R., Chaffer, C. L., Pattabiraman, D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.061 · Cited by 1,829 · see citing works
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works
A comparison of single-cell trajectory inference methods
Saelens, W., Cannoodt, R., Todorov, H., & Saeys, Y. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0071-9 · Cited by 1,670 · see citing works
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567 · see citing works
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature · doi:10.1038/nature11826 · Cited by 1,555 · see citing works
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works
Diffusion pseudotime robustly reconstructs lineage branching
Haghverdi, L., Büttner, M., Wolf, F. A., Buettner, F., & Theis, F. J. (2016) · Nature Methods · doi:10.1038/nmeth.3971 · Cited by 1,385 · see citing works
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384 · see citing works
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378 · see citing works
Bayesian approach to single-cell differential expression analysis
Kharchenko, P. V., Silberstein, L., & Scadden, D. T. (2014) · Nature Methods · doi:10.1038/nmeth.2967 · Cited by 1,348 · see citing works
Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works
A human liver cell atlas reveals heterogeneity and epithelial progenitors
Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147 · see citing works
CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL
Weibel, E. R., Stäubli, W., Gnägi, H. R., & Hess, F. A. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.42.1.68 · Cited by 1,142 · see citing works
A benchmark of batch-effect correction methods for single-cell RNA sequencing data
Tran, H. T. N., Ang, K. S., Chevrier, M., Zhang, X., Lee, N. Y. S., Goh, M., & Chen, J. (2020) · Genome Biology · doi:10.1186/s13059-019-1850-9 · Cited by 1,113 · see citing works
Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107 · see citing works
Visualizing structure and transitions in high-dimensional biological data
Moon, K. R., van Dijk, D., Wang, Z., Gigante, S., Burkhardt, D. B., Chen, W. S., Yim, K., Elzen, A. V. D., Hirn, M. J., Coifman, R. R., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0336-3 · Cited by 1,065 · see citing works
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059 · see citing works
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Ding, B., Nolan, D. J., Butler, J. M., James, D., Babazadeh, A. O., Rosenwaks, Z., Mittal, V., Kobayashi, H., Shido, K., Lyden, D. C., et al. (2010) · Nature · doi:10.1038/nature09493 · Cited by 837 · see citing works
Alcoholic liver disease: mechanisms of injury and targeted treatment
Louvet, A., & Mathurin, P. (2015) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2015.35 · Cited by 820 · see citing works
Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works
Classification of low quality cells from single-cell RNA-seq data
Ilicic, T., Kim, J. K., Kolodziejczyk, A. A., Bagger, F. O., McCarthy, D. J., Marioni, J. C., & Teichmann, S. A. (2016) · Genome Biology · doi:10.1186/s13059-016-0888-1 · Cited by 693 · see citing works
Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1
LeCouter, J. E., Moritz, D. R., Li, B., Phillips, G. D. L., Liang, X. H., Gerber, H., Hillan, K. J., & Ferrara, N. (2003) · Science · doi:10.1126/science.1079562 · Cited by 677 · see citing works
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Haynesworth, S. E., Baber, M. A., & Caplan, A. I. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199603)166:3 · Cited by 658 · see citing works
Parviz, F., Matullo, C., Garrison, W. D., Savatski, L., Adamson, J. W., Ning, G., Kaestner, K. H., Rossi, J. M., Zaret, K. S., & Duncan, S. A. (2003) · Nature Genetics · doi:10.1038/ng1175 · Cited by 588 · see citing works
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
Mitchell, C., & Willenbring, H. (2008) · Nature Protocols · doi:10.1038/nprot.2008.80 · Cited by 577 · see citing works
Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
Miyajima, A., Tanaka, M., & Itoh, T. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.010 · Cited by 570 · see citing works
Wishbone identifies bifurcating developmental trajectories from single-cell data
Setty, M., Tadmor, M. D., Reich-Zeliger, S., Angel, O., Salame, T. M., Kathail, P., Choi, K., Bendall, S., Friedman, N., & Pe'er, D. (2016) · Nature Biotechnology · doi:10.1038/nbt.3569 · Cited by 558 · see citing works
Farbehi, N., Patrick, R., Dorison, A., Xaymardan, M., Janbandhu, V. C., Wystub-Lis, K., Ho, J. W. K., Nordon, R. E., & Harvey, R. P. (2019) · eLife · doi:10.7554/elife.43882 · Cited by 546 · see citing works
Mead, J. E., & Fausto, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1558 · Cited by 535 · see citing works
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Raven, A., Lu, W.-Y., Man, T. Y., Ferreira-Gonzalez, S., O’Duibhir, E., Dwyer, B. J., Thomson, J. P., Meehan, R. R., Bogorad, R., Koteliansky, V., et al. (2017) · Nature · doi:10.1038/nature23015 · Cited by 533 · see citing works
Marcellin, P., & Kutala, B. K. (2018) · Liver International · doi:10.1111/liv.13682 · Cited by 513 · see citing works
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works
Richardson, M. M., Jonsson, J. R., Powell, E. E., Brunt, E. M., Neuschwander–Tetri, B. A., Bhathal, P. S., Dixon, J. B., Weltman, M. D., Tilg, H., Moschen, A. R., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.012 · Cited by 482 · see citing works
Braun, L., Mead, J. E., Panzica, M. A., Mikumo, R., Bell, G. I., & Fausto, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1539 · Cited by 479 · see citing works
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Lu, W.-Y., Bird, T. G., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R. V., Wojtacha, D., Man, T. Y., Mackinnon, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3203 · Cited by 479 · see citing works
Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
Russell, J. O., & Monga, S. P. (2018) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-044010 · Cited by 471 · see citing works
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461 · see citing works
Metabolic flux and the regulation of mammalian cell growth
Locasale, J. W., & Cantley, L. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.014 · Cited by 449 · see citing works
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447 · see citing works
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
Hatziapostolou, M., Polytarchou, C., Aggelidou, E., Drakaki, A., Poultsides, G. A., Jaeger, S. A., Ogata, H., Karin, M., Struhl, K., Hadzopoulou‐Cladaras, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.043 · Cited by 445 · see citing works
Hepatostat: Liver regeneration and normal liver tissue maintenance
Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444 · see citing works
The proinflammatory mediators C3a and C5a are essential for liver regeneration
Strey, C. W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L. A., Greenbaum, L. E., & Lambris, J. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030374 · Cited by 436 · see citing works
Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation
Yanger, K., Knigin, D., Zong, Y., Maggs, L., Gu, G., Akiyama, H., Pikarsky, E., & Stanger, B. Z. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.003 · Cited by 426 · see citing works
Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis
Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.024 · Cited by 420 · see citing works
Bissell, D. M., Wang, S. S., Jarnagin, W. R., & Roll, F. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118055 · Cited by 419 · see citing works
Liver regeneration — mechanisms and models to clinical application
Forbes, S. J., & Newsome, P. N. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.97 · Cited by 413 · see citing works
Met receptor tyrosine kinase: enhanced signaling through adapter proteins
Furge, K. A., Zhang, Y.-W., & Woude, G. F. V. (2000) · Oncogene · doi:10.1038/sj.onc.1203859 · Cited by 412 · see citing works
Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells
Halpern, K. B., Shenhav, R., Massalha, H., Toth, B., Egozi, A., Massasa, E. E., Medgalia, C., David, E., Giladi, A., Moor, A. E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4231 · Cited by 368 · see citing works
Isolation and Culture of Adult Mouse Hepatocytes
Li, W., Ralphs, K. L., & Tosh, D. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-019-5_13 · Cited by 303 · see citing works
DNA Binding Specificity of the CCAAT/Enhancer-binding Protein Transcription Factor Family
Osada, S., Yamamoto, H., Nishihara, T., & Imagawa, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3891 · Cited by 295 · see citing works
Joint analysis of heterogeneous single-cell RNA-seq dataset collections
Barkas, N., Petukhov, V., Nikolaeva, D., Lozinsky, Y., Demharter, S., Khodosevich, K., & Kharchenko, P. V. (2019) · Nature Methods · doi:10.1038/s41592-019-0466-z · Cited by 292 · see citing works
Kyrmizi, I., Hatzis, P., Katrakili, N., Tronche, F., Gonzalez, F. J., & Talianidis, I. (2006) · Genes & Development · doi:10.1101/gad.390906 · Cited by 285 · see citing works
Greenbaum, L. E., Li, W., Cressman, D. E., Peng, Y., Ciliberto, G., Poli, V, & Taub, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3135 · Cited by 270 · see citing works
Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance
Beyer, T. A., Xu, W., Teupser, D., Keller, U. A. D., Bugnon, P., Hildt, E., Thiery, J., Kan, Y. W., & Werner, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601950 · Cited by 267 · see citing works
Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.004 · Cited by 266 · see citing works
Schaub, J. R., Malato, Y., Gormond, C., & Willenbring, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.003 · Cited by 254 · cited 1× · see citing works
“Several cell-fate and lineage-tracing studies have determined that—under normal circumstances—the majority of new hepatocytes are derived from pre-existing hepatocytes instead of hepatic stem cells (Font-Burgada et al., 2015; Schaub et al., 2014; Yanger et al., 2014).”
BackgroundBeta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!
Yang, J., Mowry, L. E., Nejak‐Bowen, K. N., Okabe, H., Diegel, C. R., Lang, R. A., Williams, B. O., & Monga, S. P. (2014) · Hepatology · doi:10.1002/hep.27082 · Cited by 244 · see citing works
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., & Artandi, S. E. (2018) · Nature · doi:10.1038/s41586-018-0004-7 · Cited by 241 · see citing works
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Thorgersen, E. B., Barratt‐Due, A., Haugaa, H., Harboe, M., Pischke, S. E., Nilsson, P. H., & Mollnes, T. E. (2019) · Hepatology · doi:10.1002/hep.30508 · Cited by 240 · see citing works
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
Chen, F., Jimenez, R. J., Sharma, K., Luu, H. Y., Hsu, B. Y., Ravindranathan, A., Stohr, B. A., & Willenbring, H. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.001 · Cited by 236 · see citing works
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., & Wagner, E. F. (2006) · Genes & Development · doi:10.1101/gad.390506 · Cited by 232 · see citing works
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 220 · see citing works
Single-cell connectomic analysis of adult mammalian lungs
Raredon, M. S. B., Adams, T. S., Suhail, Y., Schupp, J. C., Poli, S., Neumark, N., Leiby, K. L., Greaney, A. M., Yuan, Y., Horien, C. L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw3851 · Cited by 217 · see citing works
Schirmacher, P., Geerts, A. E., Pietrangelo, A., Dienes, H. P., & Rogler, C. E. (1992) · Hepatology · doi:10.1002/hep.1840150103 · Cited by 212 · see citing works
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V., & Schultz, P. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122359899 · Cited by 210 · see citing works
Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription
Gonzalez, F. J. (2008) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.23.2 · Cited by 201 · see citing works
Matsumoto, T., Wakefield, L., Tarlow, B. D., & Grompe, M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.014 · Cited by 194 · see citing works
Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice
Bonzo, J. A., Ferry, C. H., Matsubara, T., Kim, J.-H., & Gonzalez, F. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334599 · Cited by 193 · see citing works
Temporal and tissue-specific expression of mouse ets genes.
Bhat, N. K., Fisher, R. J., Fujiwara, S., Ascione, R., & Papas, T. S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3161 · Cited by 181 · see citing works
Chaisson, M. L., Brooling, J. T., Ladiges, W., Tsai, S. Y., & Fausto, N. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15295 · Cited by 181 · see citing works
Maher, J. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116451 · Cited by 173 · see citing works
AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration
Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.10.011 · Cited by 166 · see citing works
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
Aloia, L., McKie, M. A., Vernaz, G., Cordero-Espinoza, L., Aleksieva, N., van den Ameele, J., Antonica, F., Font-Cunill, B., Raven, A., Aiese Cigliano, R., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0402-6 · Cited by 160 · see citing works
Smith, J. R., Hayman, G. T., Wang, S., Laulederkind, S. J. F., Hoffman, M. J., Kaldunski, M. L., Tutaj, M., Thota, J., Nalabolu, H. S., Ellanki, S. L. R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1041 · Cited by 155 · see citing works
Elucidating the Metabolic Regulation of Liver Regeneration
Huang, J., & Rudnick, D. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.04.034 · Cited by 149 · see citing works
Activation of Jun kinase is an early event in hepatic regeneration.
Westwick, J. K., Weitzel, C., Leffert, H. L., & Brenner, D. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117730 · Cited by 148 · see citing works
Webber, E. M., Fitzgerald, M. J., Brown, P. I., Bartlett, M. H., & Fausto, N. (1993) · Hepatology · doi:10.1002/hep.1840180622 · Cited by 145 · see citing works
Nakatsukasa, H., Evarts, R. P., Hsia, C. C., & Thorgeirsson, S. S. (1990) · PubMed · Cited by 143 · see citing works
Schiebinger, G., Shu, J., Tabaka, M., Cleary, B., Subramanian, V., Solomon, A., Gould, J., Liu, S., Lin, S., Berube, P., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.026 · Cited by 139 · see citing works
Hilaire, R. J. S., Hradek, G. T., & Jones, A. L. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.12.3797 · Cited by 136 · see citing works
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
Pu, W., Zhang, H., Huang, X., Tian, X., He, L., Wang, Y., Zhang, L., Liu, Q., Li, Y., Li, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms13369 · Cited by 136 · see citing works
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α
Inoue, Y., Yu, A., Yim, S. H., Ma, X., Krausz, K. W., Inoue, J., Xiang, C. C., Brownstein, M., Eggertsen, G., Björkhem, I., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500430-jlr200 · Cited by 135 · see citing works
Preziosi, M., Okabe, H., Poddar, M., Singh, S., & Monga, S. P. (2018) · Hepatology Communications · doi:10.1002/hep4.1196 · Cited by 135 · see citing works
Metabolic Remodeling during Liver Regeneration
Caldez, M. J., Van Hul, N., Koh, H. W. L., Teo, X. Q., Fan, J. J., Tan, P. Y., Dewhurst, M. R., Too, P. G., Talib, S. Z. A., Chiang, B. E., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.020 · Cited by 133 · see citing works
Walesky, C. M., Edwards, G., Borude, P. C., Gunewardena, S., O’Neil, M. F., Yoo, B., & Apte, U. M. (2013) · Hepatology · doi:10.1002/hep.26251 · Cited by 130 · see citing works
Wu, H., Xiao, Y., Zhang, S., Ji, S., Wei, L., Fan, F., Geng, J., Tian, J., Sun, X., Qin, F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.020 · Cited by 128 · see citing works
Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing
Ankoma‐Sey, V., Matli, M. R., Chang, K.-C., Lalazar, A., Donner, D. B., Wong, L., Warren, R. S., & Friedman, S. L. (1998) · Oncogene · doi:10.1038/sj.onc.1201912 · Cited by 125 · see citing works
Resetting the transcription factor network reverses terminal chronic hepatic failure
Nishikawa, T., Bell, A., Brooks, J. M., Setoyama, K., Melis, M., Han, B., Fukumitsu, K., Handa, K., Tian, J., Kaestner, K. H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73137 · Cited by 124 · see citing works
Zhao, L., Jin, Y., Donahue, K., Tsui, M., Fish, M., Logan, C. Y., Wang, B., & Nusse, R. (2019) · Hepatology · doi:10.1002/hep.30563 · Cited by 111 · see citing works
Hepatocyte Nuclear Factor 4α Is a Central Regulator of Bile Acid Conjugation
Inoue, Y., Yu, A., Inoue, J., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311015200 · Cited by 110 · see citing works
Liver stem cells: experimental findings and implications for human liver disease
Michalopoulos, G. K., & Khan, Z. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.004 · Cited by 109 · see citing works
Inoue, Y., Hayhurst, G. P., Inoue, J., Mori, M., & Gonzalez, F. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203126200 · Cited by 104 · see citing works
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409260102 · Cited by 104 · see citing works
Huck, I., Gunewardena, S., Español‐Suñer, R., Willenbring, H., & Apte, U. M. (2018) · Hepatology · doi:10.1002/hep.30405 · Cited by 104 · see citing works
ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation
Bhate, A., Parker, D. J., Bebee, T. W., Ahn, J., Arif, W., Rashan, E. H., Chorghade, S., Chau, A., Lee, J.-H., Anakk, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9768 · Cited by 103 · see citing works
Self-citationKiso, S., Kawata, S., Tamura, S., Higashiyama, S., Ito, N., Tsushima, H., Taniguchi, N., & Matsuzawa, Y. (1995) · Hepatology · doi:10.1002/hep.1840220535 · Cited by 100 · see citing works
Greenbaum, L. E., Cressman, D. E., Haber, B. A., & Taub, R. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118170 · Cited by 95 · see citing works
Zellmer, S., Schmidt‐Heck, W., Godoy, P., Weng, H., Meyer, C., Lehmann, T. J., Sparna, T., Schormann, W., Hammad, S., Kreutz, C., et al. (2010) · Hepatology · doi:10.1002/hep.23930 · Cited by 94 · see citing works
Jakobsen, J. S., Waage, J., Rapin, N., Bisgaard, H. C., Larsen, F. S., & Porse, B. T. (2013) · Genome Research · doi:10.1101/gr.146399.112 · Cited by 93 · see citing works
p53 REGULATES A MITOTIC TRANSCRIPTION PROGRAM AND DETERMINES PLOIDY IN NORMAL MOUSE LIVER
Kurinna, S., Stratton, S., Coban, Z., Schumacher, J. M., Grompe, M., Duncan, A. W., & Barton, M. (2013) · Hepatology · doi:10.1002/hep.26233 · Cited by 92 · see citing works
Kiso, S., Kawata, S., Tamura, S., Inui, Y., Yoshida, Y., Sawai, Y., Umeki, S., Ito, N., Yamada, A., Miyagawa, J., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50097 · Cited by 85 · see citing works
Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S., & Kalsotra, A. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0129-2 · Cited by 85 · see citing works
Self-citationAdrenergic effects on secretion of epidermal growth factor from Brunner's glands.
Olsen, P. S., Poulsen, S. S., & Kirkegaard, P. O. (1985) · Gut · doi:10.1136/gut.26.9.920 · Cited by 81 · see citing works
A novel approach to remove the batch effect of single-cell data
Zhang, F., Wu, Y., & Tian, W. (2019) · Cell Discovery · doi:10.1038/s41421-019-0114-x · Cited by 79 · see citing works
Kelley‐Loughnane, N., Sabla, G. E., Ley, C. A., Aronow, B. J., & Bezerra, J. A. (2002) · Hepatology · doi:10.1053/jhep.2002.31351 · Cited by 77 · see citing works
Hyun, J., Sun, Z., Ahmadi, A. R., Bangru, S., Chembazhi, U. V., Du, K., Chen, T., Tsukamoto, H., Rusyn, I., Kalsotra, A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci132691 · Cited by 76 · see citing works
Self-citationEpigenetic Compensation Promotes Liver Regeneration
Wang, S., Zhang, C., Hasson, D., Desai, A., SenBanerjee, S., Magnani, E., Ukomadu, C., Lujambio, A., Bernstein, E., & Sadler, K. C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.05.034 · Cited by 73 · see citing works
Underlying potential: cellular and molecular determinants of adult liver repair
Diehl, A. M., & Chute, J. P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69966 · Cited by 71 · see citing works
Cellular and molecular basis of liver regeneration
Bangru, S., & Kalsotra, A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.004 · Cited by 66 · see citing works
Self-citationEpidermal Growth Factor: Its Biologic and Metabolic Effects With Emphasis on the Hepatocyte
Hilaire, J. R. S., & Jones, A. L. (1982) · Hepatology · doi:10.1002/hep.1840020515 · Cited by 66 · see citing works
Role of hepatocyte nuclear factor 4α in control of blood coagulation factor gene expression
Inoue, Y., Peters, L. L., Yim, S. H., Inoue, J., & Gonzalez, F. J. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0013-5 · Cited by 65 · see citing works
Jin, J., Hong, I., Lewis, K., Iakova, P. A., Breaux, M., Jiang, Y., Sullivan, E. M., Jawanmardi, N., Timchenko, L., & Timchenko, N. A. (2014) · Hepatology · doi:10.1002/hep.27295 · Cited by 62 · see citing works
A Complement–IL-4 Regulatory Circuit Controls Liver Regeneration
DeAngelis, R. A., Markiewski, M. M., Kourtzelis, I., Rafail, S., Syriga, M., Sandor, A., Maurya, M. R., Gupta, S., Subramaniam, S., & Lambris, J. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101925 · Cited by 60 · see citing works
Servillo, G., Fazia, M. A. D., & Sassone‐Corsi, P. (1998) · Genes & Development · doi:10.1101/gad.12.23.3639 · Cited by 60 · see citing works
Sladky, V. C., Knapp, K., Soratroi, C., Heppke, J., Eichin, F., Rocamora-Reverte, L., Szabo, T., Bongiovanni, L., Westendorp, B., Moreno, E., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.12.016 · Cited by 55 · see citing works
TGFβ gene transcription in normal and neoplastic liver growth
Carr, B. I., Huang, T. H., Itakura, K., Noël, M., & Marceau, N. (1989) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240390413 · Cited by 52 · see citing works
The Dynamic Chromatin Architecture of the Regenerating Liver
Wang, A. W., Wang, Y., Zahm, A., Morgan, A. R., Wangensteen, K., & Kaestner, K. (2019) · bioRxiv · doi:10.1016/j.jcmgh.2019.09.006 · Cited by 47 · see citing works
Liu, Y., Lui, E. L. H., Friedman, S. L., Li, L., Ye, T., Chen, Y., Poon, R. T. P., Wo, J. Y. H., Kok, T. W., & Fan, S. T. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.127 · Cited by 37 · see citing works
A detailed methodology of partial hepatectomy in the mouse
Boyce, S., & Harrison, D. J. (2008) · Lab Animal · doi:10.1038/laban1108-529 · Cited by 36 · see citing works
TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury
Wang, A. W., Wangensteen, K. J., Wang, Y. J., Zahm, A. M., Moss, N., Noam Erez, A., & Kaestner, K. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95120 · Cited by 33 · see citing works
Çolak, D., Al‐Harazi, O., Mustafa, O. M., Meng, F., Assiri, A. M., Dhar, D. K., & Broering, D. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-61826-1 · Cited by 30 · see citing works
p53 may positively regulate hepatocyte proliferation in rats
Inoue, Y., Tomiya, T., Yanase, M., Arai, M., Ikeda, H., Tejima, K., Ogata, I., Kimura, S., Omata, M., & Fujiwara, K. (2002) · Hepatology · doi:10.1053/jhep.2002.34942 · Cited by 29 · see citing works
Dysregulated activation of fetal liver programme in acute liver failure
Hyun, J., Oh, S., Premont, R. T., Guy, C. D., Berg, C. L., & Diehl, A. M. (2019) · Gut · doi:10.1136/gutjnl-2018-317603 · Cited by 28 · see citing works
Sato, Y., Katoh, Y., Matsumoto, M., Sato, M., Ebina, M., Itoh‐Nakadai, A., Funayama, R., Nakayama, K., Unno, M., & Igarashi, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.774547 · Cited by 22 · see citing works
Induction of DNA polymerase activities in the regenerating rat liver
Yang, C. L., Zhang, S. J., Toomey, N., Palmer, T. N., & Lee, M. (1991) · Biochemistry · doi:10.1021/bi00244a024 · Cited by 20 · see citing works
Segregated hepatocyte proliferation and metabolic states within the regenerating mouse liver
Minocha, S., Villeneuve, D., Rib, L., Moret, C., Guex, N., & Herr, W. (2017) · Hepatology Communications · doi:10.1002/hep4.1102 · Cited by 16 · see citing works
COOK, D. J., Achanta, S., Hoek, J. B., Ogunnaike, B. A., & Vadigepalli, R. (2018) · BMC Systems Biology · doi:10.1186/s12918-018-0605-7 · Cited by 14 · see citing works
A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice
Zahm, A. M., Wang, A. W., Wang, Y. J., Schug, J., Wangensteen, K. J., & Kaestner, K. H. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.11.025 · Cited by 12 · see citing works
Transcriptome Temporal and Functional Analysis of Liver Regeneration Termination
Rychtrmoc, D., Hubálková, L., Víšková, A., Libra, A., Bunček, M., & Červinková, Z. (2012) · Physiological Research · doi:10.33549/physiolres.932393 · Cited by 11 · see citing works
Chaisson, M. L., Brooling, J. T., Ladiges, W., Tsai, S. Y., & Fausto, N. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215295 · Cited by 11 · see citing works
Achanta, S., Verma, A., Srivastava, A., Nilakantan, H., Hoek, J. B., & Vadigepalli, R. (2018) · Gene Expression · doi:10.3727/105221618x15361728786767 · Cited by 7 · see citing works
Kuttippurathu, L., Patra, B., COOK, D. J., Hoek, J. B., & Vadigepalli, R. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00097.2016 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Angiodiversity and organotypic functions of sinusoidal endothelial cells
Reiners-Koch, P.-S., Lee, K. H., Goerdt, S., & Augustin, H. G. (2021) · Angiogenesis · doi:10.1007/s10456-021-09780-y · Cited by 97 · see citing works
Loss of liver function in chronic liver disease: An identity crisis
Berasain, C., Arechederra, M., Argemí, J., Fernández-Barrena, M. G., & Avila, M. A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.001 · Cited by 99 · see citing works
Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2
Cheng, N., Kim, K.-H., & Lau, L. F. (2022) · JCI Insight · doi:10.1172/jci.insight.158207 · Cited by 87 · see citing works
“ing PHx, with many genes being rapidly activated (4, 5).”
Decoding aging-dependent regenerative decline across tissues at single-cell resolution
Cai, Y., Xiong, M., Xin, Z., Liu, C., Ren, J., Yang, X., Lei, J., Li, W., Liu, F., Chu, Q., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.014 · Cited by 91 · see citing works
A spatiotemporal atlas of mouse liver homeostasis and regeneration
Xu, J., Guo, P., Hao, S., Shangguan, S., Shi, Q., Volpe, G., Huang, K., Zuo, J., An, J., Yuan, Y., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01709-7 · Cited by 75 · see citing works
In vivo interaction screening reveals liver-derived constraints to metastasis
Borrelli, C., Roberts, M., Eletto, D., Hussherr, M., Fazilaty, H., Valenta, T., Lafzi, A., Kretz, J. A., Vinzoni, E. G., Karakatsani, A., et al. (2024) · Nature · doi:10.1038/s41586-024-07715-3 · Cited by 63 · see citing works
Hepatocyte organoids and cell transplantation: What the future holds
Peng, W. C., Kraaier, L. J., & Kluiver, T. A. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00579-x · Cited by 59 · see citing works
Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death
Arif, W., Mathur, B., Saikali, M. F., Chembazhi, U. V., Toohill, K., Song, Y. J., Hao, Q., Karimi, S. S., Blue, S. M., Yee, B. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35932-3 · Cited by 50 · see citing works
Self-citationSingle-cell and spatially resolved transcriptomics for liver biology
Lin, P., Yan, X., Jing, S., Wu, Y., Shan, Y., Guo, W., Gu, J., Li, Y., Zhang, H., & Li, H. (2023) · Hepatology · doi:10.1097/hep.0000000000000387 · Cited by 53 · see citing works
Trinh, V. Q.-H., Lee, T.-F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.adf6696 · Cited by 45 · see citing works
Wnt/-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities
Hu, S., & Monga, S. P. (2021) · Gene Expression · doi:10.3727/105221621x16111780348794 · Cited by 44 · see citing works
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.
Wang, S., Wang, X., Shan, Y., Tan, Z., Su, Y., Cao, Y., Wang, S., Dong, J., Gu, J., & Wang, Y. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.01.013 · Cited by 40 · see citing works
Hendriks, D. F. G., Artegiani, B., Margaritis, T., Zoutendijk, I., Lopes, S. M. C. D. S., & Clevers, H. C. (2024) · Nature Communications · doi:10.1038/s41467-024-48550-4 · Cited by 39 · see citing works
Lin, Y.-H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M.-H., Corbitt, N., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.007 · Cited by 33 · see citing works
Oliva‐Vilarnau, N., Beusch, C. M., Sabatier, P., Sakaraki, E., Tjaden, A., Grätz, L., Büttner, F., Dorotea, D., Nguyen, M. A., Bergqvist, F., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000648 · Cited by 33 · see citing works
Niu, N., Ye, J., Hu, Z., Zhang, J., & Wang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087076 · Cited by 32 · see citing works
Cell metabolism-based therapy for liver fibrosis, repair, and hepatocellular carcinoma
Gilgenkrantz, H., Paradis, V., & Lotersztajn, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000479 · Cited by 31 · see citing works
Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
Direct mechanical exposure initiates hepatocyte proliferation
Li, W., Wu, Y. C., Hu, W., Zhou, J., Shu, X., Zhang, X., Zhang, Z., Wu, H. C., Du, Y. M., Lü, D., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100905 · Cited by 28 · see citing works
Dynamic 3D genome reorganization during development and metabolic stress of the porcine liver
Chen, L., Li, J., Yuan, R., Wang, Y., Zhang, J., Lin, Y., Wang, L., Zhu, X., Zhu, W., Bai, J., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00416-z · Cited by 28 · see citing works
Ruz‐Maldonado, I., González, J. T., Zhang, H., Sun, J., Bort, A., Kabir, I., Kibbey, R. G., Suárez, Y., Greif, D. M., & Fernandez-Hernando, C. F. (2024) · Nature Communications · doi:10.1038/s41467-024-45439-0 · Cited by 26 · see citing works
Novel insights into liver homeostasis and regeneration
Michalopoulos, G. K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00454-0 · Cited by 24 · see citing works
Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?
Hu, Y., Wang, R., Liu, J., Wang, Y., & Dong, J. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000267 · Cited by 22 · see citing works
Biomechanics in liver regeneration after partial hepatectomy
Wu, Y. C., Li, N., Shu, X., Li, W., Zhang, X., Lü, D., & Long, M. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1165651 · Cited by 22 · see citing works
Pita-Juárez, Y. H., Karagkouni, D., Kalavros, N., Melms, J. C., Niezen, S., Delorey, T. M., Essene, A. L., Brook, O. R., Pant, D. B., Skelton-Badlani, D., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03499-5 · Cited by 21 · see citing works
Cell atlas of the regenerating human liver after portal vein embolization
Brazovskaja, A., Gomes, T., Holtackers, R., Wahle, P., Körner, C., He, Z., Schaffer, T., Eckel, J. C., Hänsel, R., Santel, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49236-7 · Cited by 28 · see citing works
Cell atlas of CCl4-induced progressive liver fibrosis reveals stage-specific responses
Guo, P.-C., 吉林大学动物医学学院人兽共患病研究所人兽共患病研究教育部重点实验室, 人., Zuo, J., Huang, K.-K., Lai, G., Zhang, X., An, J., Li, J., Li, L., Wu, L. L., et al. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.031 · Cited by 17 · see citing works
Eski, S. E., Mi, J., Pozo‐Morales, M., Hovhannisyan, G., Perazzolo, C., Manco, R., Ez-Zammoury, I., Barbhaya, D., Lefort, A., Libert, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60334-y · Cited by 18 · see citing works
The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2
Derham, J. M., & Kalsotra, A. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221124 · Cited by 16 · see citing works
Self-citationTissue regeneration: Unraveling strategies for resolving pathological fibrosis
Li, J., Wang, S., Yuan, J., Mao, X., Wang, X., Zhang, L., Dong, Q., Chen, Z., Wang, Y., & Tang, N. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.002 · Cited by 16 · see citing works
SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes
Peng, J., Serrano, G., Traniello, I. M., Calleja-Cervantes, M. E., Chembazhi, U. V., Bangru, S., Ezponda, T., Rodríguez-Madoz, J. R., Kalsotra, A., Prósper, F., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03319-7 · Cited by 12 · see citing works
Self-citationLiver cell therapies: cellular sources and grafting strategies
Zhang, W., Cui, Y., Du, Y., Yang, Y., Fang, T., Lu, F., Kong, W.-X., Xiao, C., Shi, J., Reid, L. M., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1002-1 · Cited by 11 · see citing works
Llorens‐Giralt, P., Ruiz‐Romero, M., Nurtdinov, R., Herranz‐Itúrbide, M., Vicent, G. P., Serras, F., Fabregat, I., & Corominas, M. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100887 · Cited by 13 · see citing works
The essential role of O-GlcNAcylation in hepatic differentiation
Robarts, D. R., Kotulkar, M., Paine‐Cabrera, D., Venneman, K. K., Hanover, J. A., Zachara, N. E., Slawson, C. M., & Apte, U. M. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000283 · Cited by 12 · see citing works
Keshvari, S., Masson, J. J. R., Ferrari-Cestari, M., Bodea, L., Nooru‐Mohamed, F., Tse, B. W.-C., Sokolowski, K. A., Batoon, L., Patkar, O. L., Sullivan, M. A., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00347.2023 · Cited by 10 · see citing works
Dewald, Z., Adesanya, O. A., Bae, H., Gupta, A. S., Derham, J. M., Chembazhi, U. V., & Kalsotra, A. (2024) · Nature Communications · doi:10.1038/s41467-024-53378-z · Cited by 10 · see citing works
Self-citationBasal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
de Lara, S. B., Kemmer, S., Biermayer, I., Feiler, S., Vlasov, A., D’Alessandro, L. A., Helm, B., Mölders, C., Dieter, Y., Ghallab, A., et al. (2024) · Molecular Systems Biology · doi:10.1038/s44320-023-00007-4 · Cited by 10 · see citing works
Unveiling the power of microenvironment in liver regeneration: an in-depth overview
Hu, Y., Wang, R., An, N. A., Li, C., Wang, Q., Cao, Y., Li, C., Liu, J., & Wang, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1332190 · Cited by 12 · see citing works
Emerging roles of RNA‐binding proteins in fatty liver disease
Adesanya, O. A., Das, D., & Kalsotra, A. (2024) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1840 · Cited by 9 · see citing works
Self-citationCell and tissue reprogramming: Unlocking a new era in medical drug discovery
Sen, C. K., Friday, A. J., & Roy, S. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100077 · Cited by 9 · see citing works
Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease
Chembazhi, U. V., Bangru, S., Dutta, R. K., Das, D., Peiffer, B. J., Natua, S., Toohill, K., Leona, A., Purwar, I., Bhowmik, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63251-2 · Cited by 8 · see citing works
Self-citationKong, Z., Zhu, L., Liu, Y., Liu, Y., Chen, G., Jiang, T., & Wang, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116063 · Cited by 8 · see citing works
Genetic and Cellular Contributions to Liver RegenerationPreprint
Liang, R. J., Lin, Y.-H., & Zhu, H. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040832 · Cited by 8 · see citing works
Hu, Y., Du, G., Li, C., Wang, R., Liu, J., Wang, Y., & Dong, J. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2024.101321 · Cited by 7 · see citing works
Rudder, M. D., Manco, R., Coubeau, L., Fontaine, A., Bertrand, C., Leclercq, I. A., & Dili, A. (2024) · Hepatology · doi:10.1097/hep.0000000000000900 · Cited by 7 · see citing works
Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing
Xu, J., Hao, S., Shi, Q., Deng, Q., Jiang, Y., Guo, P., Yuan, Y., Shi, X., Shangguan, S., Zheng, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.833392 · Cited by 6 · see citing works
Sonam, S., Bangru, S., Perry, K. J., Chembazhi, U. V., Kalsotra, A., & Henry, J. J. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.08.007 · Cited by 6 · see citing works
Self-citationDu, Y., Jian, S., Wang, X., Yang, C., Qiu, H., Fang, K., Yan, Y., Shi, J., & Li, J. (2023) · Aging · doi:10.18632/aging.204775 · Cited by 6 · see citing works
Blood flow‐induced angiocrine signals promote organ growth and regeneration
Follert, P., Große‐Segerath, L., & Lammert, E. (2024) · BioEssays · doi:10.1002/bies.202400207 · Cited by 8 · see citing works
Cell atlas of the regenerating human liver after portal vein embolizationPreprint
Brazovskaja, A., Gomes, T., Körner, C., He, Z., Schaffer, T., Eckel, J. C., Hänsel, R., Santel, M., Denecke, T., Dannemann, M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.03.444016 · Cited by 6 · see citing works
Inui, J., Ueyama-Toba, Y., Mitani, S., & Mizuguchi, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285783 · Cited by 5 · see citing works
Systems-level analysis of transcriptome reorganization during liver regeneration
Porukala, M., & Vinod, P. K. U. (2022) · Molecular Omics · doi:10.1039/d1mo00382h · Cited by 5 · see citing works
Peng, J., Serrano, G., Traniello, I. M., Calleja-Cervantes, M. E., Chembazhi, U. V., Bangru, S., Ezponda, T., Rodríguez-Madoz, J. R., Kalsotra, A., Prósper, F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.03.023002 · Cited by 5 · see citing works
Self-citationESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2025) · Genes & Development · doi:10.1101/gad.352129.124 · Cited by 4 · see citing works
Self-citationTwo types of regenerative cell populations appear in acute liver injury
Aoyagi, T., Goya, T., Imoto, K., Azuma, Y., Hioki, T., Kohjima, M., Tanaka, M., Oda, Y., & Ogawa, Y. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102503 · Cited by 4 · see citing works
Ni, L., Chen, F., Ran, R., Li, X., Jin, N., Zhang, H., & Peng, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114300 · Cited by 4 · see citing works
Zheng, Q., Li, X., Li, F., Xu, Z., Cai, Y., Li, C. H., Xue, X., Li, S., Sun, R., Fan, G., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.03.028 · Cited by 3 · see citing works
Xu, C., Su, R., Song, Y., Shu, W., Yang, M., Yang, Z., Xu, X., & Wei, X. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70365 · Cited by 3 · see citing works
Neutrophil and macrophage crosstalk might be a potential target for liver regeneration
Chen, Y., Yang, Y., Lu, J., Chen, H., Shi, Z., Wang, X., Xu, N., Xu, X., & Wang, S. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13803 · Cited by 3 · see citing works
The influence of tissue spatial geometry and functional organisation on liver regeneration
Aloia, L. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.011 · Cited by 3 · see citing works
Single-cell analyses of the corneal epithelium: Unique cell types and gene expression profilesPreprint
Sonam, S., Bangru, S., Perry, K. J., Kalsotra, A., & Henry, J. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.06.240036 · Cited by 3 · see citing works
Self-citationCell networks in the mouse liver during partial hepatectomy
Li, B., Rodrigo‐Torres, D., Pelz, C., Innes, B. T., Canaday, P. S., Chai, S., Zandstra, P. W., Bader, G. D., & Grompe, M. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102683 · Cited by 2 · see citing works
Fang, T., Yang, C., Qiu, H., Du, Y., Wang, X., Li, Y., Xu, M., Liu, C., Li, X., Guo, N., et al. (2026) · Advanced Science · doi:10.1002/advs.202517126 · Cited by 2 · see citing works
Hu, Y., Song, S., Wang, R., An, N., Diao, J., Chen, Y., Liu, J., & Lv, G. (2026) · Cell Proliferation · doi:10.1111/cpr.70214 · Cited by 3 · see citing works
Akiyama, S., Saku, N., Miyata, S., Ite, K., Nonaka, H., Toyoda, M., Kamiya, A., Kiyono, T., Kimura, T., Kasahara, M., et al. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.009 · Cited by 2 · see citing works
Breaking the rules of cell biology: Lessons from the liver's exceptional regenerative capacity
Knouse, K. A. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-06-0281 · Cited by 1 · see citing works
Cell atlas of the regenerating human liver after portal vein embolizationPreprint
Gomes, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.17632/yp3txzw64c.1 · Cited by 2 · see citing works
Dysregulated RNA splicing induces regeneration failure in alcohol-associated liver diseasePreprint
Chembazhi, U. V., Bangru, S., Dutta, R. K., Das, D., Peiffer, B. J., Natua, S., Toohill, K., Leona, A., Purwar, I., Bhowmik, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.626099 · Cited by 2 · see citing works
Self-citationAberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors
Nishikawa, Y. (2024) · Pathology International · doi:10.1111/pin.13441 · Cited by 1 · see citing works
Du, Y., Yang, Y., Zhang, Y., Zhang, F., Wu, J., & Yin, J. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000630 · Cited by 1 · see citing works
Vasseur, L., Gheeraert, C., Dubois‐Chevalier, J., Very, N., Guille, L., Saleh, M. B., Boulet, C., Sobolewski, C., Loyer, P., Berthier, A., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003547 · Cited by 1 · see citing works
He, Y., Qi, W., Xie, X., & Jiang, H. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01871-1 · Cited by 1 · see citing works
ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602336 · Cited by 1 · see citing works
Self-citationZhou, W., Chembazhi, U. V., Huang, J., Bangru, S., Dean, A. E., Asokakumar, A., Kalsotra, A., Rudnick, D. A., & Anakk, S. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101858
Self-citationChen, T., & Diehl, A. M. (2021) · Hepatology · doi:10.1002/hep.31827
Arif, W., Mathur, B., Saikali, M. F., Chembazhi, U. V., Blue, S. M., Yee, B. A., Nostrand, E. L. V., Bangru, S., Hao, Q., Yeo, G. W., et al. (2021) · bioRxiv · doi:10.1101/2021.07.10.451875
Self-citationわが国企業における資金調達のグローバル化動向 : 資金調達のグローバル化と国際会計基準(自由論題)
及川, 勝. (2000)
Inui, J., Ueyama-Toba, Y., Mitani, S., & Mizuguchi, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2118517/v1
Borrelli, C., Roberts, M., Eletto, D., Lafzi, A., Kretz, J. A., Fazilaty, H., Hussherr, M., Vinzoni, E. G., Handler, K., Michler, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.15.540681
Keshvari, S., Masson, J. J. R., Ferrari-Cestari, M., Bodea, L., Nooru‐Mohamed, F., Tse, B. W.-C., Sokolowski, K. A., Batoon, L., Patkar, O. L., Sullivan, M. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.538022
Liu, J., Hu, Y., Du, G., Li, C., Wang, R., Wang, Y., & Dong, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3131364/v1
Hepatocytes of mice and men: Different regenerative signals?
Michalopoulos, G. K. (2023) · Hepatology · doi:10.1097/hep.0000000000000693
Lazovska, M., Salmiņa, K., Pjanova, D., Gerashchenko, B. I., & Erenpreisa, J. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.26.586724
Zheng, Q., Li, X., Xu, Z., Cai, Y., Li, F., Xue, X., Li, S., Sun, R., Fan, G., Wu, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.07.602368
Two types of regeneration mechanism in acute liver injuryPreprint
Aoyagi, T., Goya, T., Imoto, K., Azuma, Y., Hioki, T., Kohjima, M., Tanaka, M., Oda, Y., & Ogawa, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.04.606468
Zhang, M., Lv, Z., Zhao, L., Zeng, Q., Wu, Y., Zhou, J., Xi, J., Pei, X., Wang, H., Li, C., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1579121
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Lei, S., Lu, W., Peng, C., & Shan, Z. (2026) · eLife · doi:10.1101/2025.08.21.671501
Guerra, S., Birrer, D. L., Ungethüm, U., Jang, J., Clavien, P., & Humar, B. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003216
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injuryPreprint
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Lei, S., Lu, W., Peng, C., & Shan, Z. (2025) · eLife · doi:10.7554/elife.108646
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injuryPreprint
Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Peng, C., & Shan, Z. (2025) · eLife · doi:10.7554/elife.108646.1
Shi, X., Mekis, G., Simms, K. J., Gao, B., & Zhang, P. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108959 · Cited by 1 · see citing works
Synthetic control of implanted engineered liver tissue growth
Stoddard, A. E., Kumar, V., Tzouanas, C., Hui, V. W., Li, J., Jain, A., Farrell, A., Bhatia, S. N., & Chen, C. S. (2026) · Science Advances · doi:10.1126/sciadv.adz8362
Metabolic Factors Affecting Liver Regeneration
Ammann, M., & Starlinger, P. P. (2026) · Springer eBooks · doi:10.1007/978-3-032-10997-2_3
Zhang, J., Xu, Y., & Lu, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1743286
Transient steatosis reprograms MDMs for liver repair
Woodhoo, A., & Varela‐Rey, M. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01479-y
CellCousin2: an optimized system for partial ablation and tracing of regenerative lineages
Hovhannisyan, G., Akhourbi, T., Eski, S. E., Pirson, I., Gurzov, E. N., & Singh, S. P. (2026) · npj Regenerative Medicine · doi:10.1038/s41536-026-00473-y
Transient suppression of the ECM1 gatekeeper is essential for HGF/c-MET-driven liver regenerationPreprint
Yao, Y., Li, Y., Huang, C., Ma, J., Xu, L., Wolf, S. D., Gilljam, J., Zeng, H., Munker, S., Cao-Ehlker, X., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.08.730887
Organelle-targeted nanomedicine for metabolic reprogramming in regenerative medicine
Chandrasekaran, S., Duraisamy, N., Jagadeesan, M., Palukuri, Y. K., Santhoshkumar, M., Sah, A. K., Sundaram, T., & Senthilkumar, D. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103190
- Authors
- Chembazhi, U. V., Bangru, S., Hernaez, M., & Kalsotra, A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Kalsotra, Auinash
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2021-03-01
- Volume
- 31
- Issue
- 4
- Pages
- 576-591
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- PMC
- PMC8015853
- OpenAlex
- W3133820991
- Cited by
- 102
- References
- 147
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 22 · 2023: 26 · 2022: 9 · 2021: 10 · 2020: 2
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- NIH (R01HL126845, R01AA010154, T32-EB019944)
- Muscular Dystrophy Association (MDA514335)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, hepatocyte proliferation, cellular plasticity, cell-to-cell communication, non-parenchymal cells, developmental gene regulatory networks, single-cell transcriptomics
- MeSH terms
- Cell Plasticity, Animals, Hepatectomy, Liver, Liver Regeneration, Hepatocytes, Cell Proliferation, Mice, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
