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Tissue Stem Cells: Architects of Their Niches
Open accessAbstract
Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental "niche" to transition between quiescent and regenerative states. Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues in our body-to highlight similarities and differences in niche constituents and how SCs mediate natural tissue rejuvenation and perform regenerative acts prompted by injuries. We discuss how these communication networks break down during aging and how understanding tissue SCs has led to major advances in regenerative medicine.
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“Tissue regeneration requires coordination between resident stem cells and local niche cells1,2.”
From Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration (2023) · cites this paper as [1]
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Metadata
- Authors
- Fuchs, E., & Blau, H. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Fuchs, Elaine
- Blau, Helen M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 27
- Issue
- 4
- Pages
- 532-556
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC7861346
- OpenAlex
- W3090928815
- Cited by
- 332
- References
- 235
- Citations by year
- 2026: 48 · 2025: 80 · 2024: 76 · 2023: 46 · 2022: 48 · 2021: 34
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Li Ka Shing Foundation
- American Heart Association
- Foundation for the National Institutes of Health
- Baxter International Foundation
- California Institute for Regenerative Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- tissue stem cells, stem cell niche, tissue homeostasis, wound healing, skin epithelium, skeletal muscle, tissue rejuvenation, aging, regenerative medicine
- MeSH terms
- Rejuvenation, Stem Cells, Muscle, Skeletal, Regenerative Medicine
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