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TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate

García-Prat, Laura, Kaufmann, Kerstin B., Schneiter, Florin, Voisin, Veronique, Murison, Alex, Chen, Jocelyn, Chan-Seng-Yue, Michelle, Gan, Olga I., McLeod, Jessica L., Smith, Sabrina A., Shoong, Michelle C., Parris, Darrien, Pan, Kristele, Zeng, Andy G.X., Krivdova, Gabriela, Gupta, Kinam, Takayanagi, Shin-Ichiro, Wagenblast, Elvin, Wang, Weijia, Lupien, Mathieu, Schroeder, Timm, Xie, Stephanie Z., Dick, John E.·2021·Cell Stem Cell
DOI 10.1016/j.stem.2021.07.003
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Image 2
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Image 3
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Figure 3 TFEB-induced endolysosomal degradation inhibits c-MYC-driven anabolic processes and promotes LT-HSC quiescence
Figure 3 TFEB-induced endolysosomal degradation inhibits c-MYC-driven anabolic processes and promotes LT-HSC quiescenceCC-BY-NC-ND · From the PDF
Figure 4 Lysosomal activity governs LT-HSC lineage specification
Figure 4 Lysosomal activity governs LT-HSC lineage specificationCC-BY-NC-ND · From the PDF
Figure 5 Enhanced TFEB-driven lysosomal activity differentiates LT- from ST-HSCs
Figure 5 Enhanced TFEB-driven lysosomal activity differentiates LT- from ST-HSCsCC-BY-NC-ND · From the PDF
Image 7
CC-BY-NC-ND · From the PDF
Figure 7 Lysosomal activity governs LT-HSC self-renewal
Figure 7 Lysosomal activity governs LT-HSC self-renewalCC-BY-NC-ND · From the PDF

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Cites

Show all 11 references

Research works printed but not linked: 41

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Cited by

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Metadata

Authors
García-Prat, L., Kaufmann, K. B., Schneiter, F., Voisin, V., Murison, A., Chen, J., Chan-Seng-Yue, M., Gan, O. I., McLeod, J. L., Smith, S. A., Shoong, M. C., Parris, D., Pan, K., Zeng, A. G. X., Krivdova, G., Gupta, K., Takayanagi, S.-I., Wagenblast, E., Wang, W., Lupien, M., Schroeder, T., Xie, S. Z., & Dick, J. E.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2021-10
Volume
28
Issue
10
Pages
1838-1850.e10
ISSN
1934-5909
DOI
10.1016/j.stem.2021.07.003
Cited by
140
References
11
Language
en
Licence
Funders
  • Canadian Institutes of Health Research (201910MFE-430959-284655, RN380110-409786)
  • International Development Research Centre
  • Canadian Cancer Society (703212)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (179490)
  • Government of Ontario
  • University of Toronto
  • OICR
  • European Molecular Biology Organization (ALTF 420-2017)
  • Terry Fox Research Institute
  • Canada First Research Excellence Fund
  • Princess Margaret Cancer Foundation
  • Ontario Institute for Cancer Research
  • Canada Research Chairs
  • Eidgenössische Technische Hochschule Zürich

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CoChat. (2026). Citation check: TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate. https://app.cochat.ai/papers/10.1016/j.stem.2021.07.003
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García-Prat, L., Kaufmann, K. B., Schneiter, F., Voisin, V., Murison, A., Chen, J., Chan-Seng-Yue, M., Gan, O. I., McLeod, J. L., Smith, S. A., Shoong, M. C., Parris, D., Pan, K., Zeng, A. G. X., Krivdova, G., Gupta, K., Takayanagi, S.-I., Wagenblast, E., Wang, W., . . . Dick, J. E. (2021). TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.07.003