The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages
Open accessAbstract
Tissue-resident macrophages, such as microglia, Kupffer cells, and Langerhans cells, derive from Myb-independent yolk sac (YS) progenitors generated before the emergence of hematopoietic stem cells (HSCs). Myb-independent YS-derived resident macrophages self-renew locally, independently of circulating monocytes and HSCs. In contrast, adult blood monocytes, as well as infiltrating, gut, and dermal macrophages, derive from Myb-dependent HSCs. These findings are derived from the mouse, using gene knockouts and lineage tracing, but their applicability to human development has not been formally demonstrated. Here, we use human induced pluripotent stem cells (iPSCs) as a tool to model human hematopoietic development. By using a CRISPR-Cas9 knockout strategy, we show that human iPSC-derived monocytes/macrophages develop in an MYB-independent, RUNX1-, and SPI1 (PU.1)-dependent fashion. This result makes human iPSC-derived macrophages developmentally related to and a good model for MYB-independent tissue-resident macrophages, such as alveolar and kidney macrophages, microglia, Kupffer cells, and Langerhans cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These cells closely resemble human foetal microglia with regards to transcriptional signature and express high levels of microglial genes29,30.”
From PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages (2021) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We have recently directly demonstrated that these derive from MYB-independent, RUNX1- and PU.1-dependent precursors, characteristic of yolk sac-derived macrophages (Buchrieser et al., 2017, Vanhee et al., 2015).”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Buchrieser et al., 2017
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, only our protocol has direct evidence by gene knockout for producing MYB-independent primitive macrophages (Buchrieser et al., 2017).”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Buchrieser et al., 2017
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Our own work (Buchrieser et al., 2017) and that of others (Hoeffel et al., 2015) indicates that this protocol produces MYB-independent myeloid cells, recapitulating an embryonic ontogeny, and lineage-tracking studies in mouse have demonstrated that microglia derive from primitive, yolk sac macrophages that migrate into the developing brain (Ginhoux et al., 2010, Ginhoux et al., 2013).”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Buchrieser et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 3×
“Murine YS-derived macrophages and fetal monocytes seed most tissues before HSC-derived definitive hematopoiesis (Ginhoux et al., 334 Stem Cell Reports j Vol. 8 j 334–345 j February 14, 2017 j ª 2017 The A This is an open access article under the CC BY license (http://creativecommo 2010; Hoeffel et al., 2015; Kierdorf…”
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · cited 2×
“…et al., 2015) where, with the exception of dermal (Tamoutounour et al., 2013), gut (Bain et al., 2014), and a fraction of cardiac macrophages (Epelman et al., 2014), they self-renew throughout life with minor contribution from adult blood monocytes (Epelman et al., 2014; Hashimoto et al., 2013).”
Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,457
Bain, C. C., Bravo-Blas, A., Scott, C. L., Gomez Perdiguero, E., Geissmann, F., Henri, S., Malissen, B., Osborne, L. C., Artis, D., & Mowat, A. M. (2014) · Nature Immunology · doi:10.1038/ni.2967 · Cited by 1,178
Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 218
Monzón-Sandoval, J., Burlacu, E., Agarwal, D., Handel, A. E., Wei, L., Davis, J., Cowley, S. A., Cader, M. Z., & Webber, C. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049349 · Cited by 18
Wang, C., Liu, J., & Li, W. (2023) · Cell Proliferation · doi:10.1111/cpr.13425 · Cited by 18
The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells
Ackermann, M., Dragon, A. C., & Lachmann, N. (2020) · Transfusion Medicine and Hemotherapy · doi:10.1159/000512721 · Cited by 18
Nam, K. H., Yi, S. A., Jang, H. J., Han, J., & Lee, J. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01260-z · Cited by 17
Rasaei, R., Tyagi, A., Rasaei, S., Lee, S., Yang, S., Kim, K.-S., Ramakrishna, S., & Hong, S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03136-z · Cited by 18
Emerging roles of macrophages in heart failure and associated treatment approaches
Xie, L., Chen, J., Wang, Y., Jin, C., Xie, Y., Ma, H., & Xiang, M. (2023) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223231168755 · Cited by 16
Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology
Joshi, K., Cameron, F. J., Tiwari, S., Mannering, S. I., Elefanty, A. G., & Stanley, E. G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.635662 · Cited by 18
Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells
Ackermann, M., Kuhn, A., Kunkiel, J., Merkert, S., Martin, U., Moritz, T., & Lachmann, N. (2017) · Transfusion Medicine and Hemotherapy · doi:10.1159/000477129 · Cited by 15
Cerneckis, J., & Shi, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1198715 · Cited by 14
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia
Claes, C., Daele, J. V. D., & Verfaillie, C. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.019 · Cited by 13
Shah, Z., Филоненко, Е. С., Ramensky, V. E., Fan, C., Wang, C., Ullah, H., Zhang, B., Volchkov, P., & Samokhvalov, I. M. (2020) · Haematologica · doi:10.3324/haematol.2020.249193 · Cited by 13
Salah, A., Li, Y., Wang, H., Qi, N., & Wu, Y. (2021) · DNA and Cell Biology · doi:10.1089/dna.2020.6087 · Cited by 13
Var, S. R., Strell, P., Johnson, S. T., Roman, A., Vasilakos, Z., & Low, W. C. (2023) · Cell Transplantation · doi:10.1177/09636897231171001 · Cited by 15
Rajab, N., Rutar, M., Laslett, A. L., & Wells, C. A. (2018) · Differentiation · doi:10.1016/j.diff.2018.10.001 · Cited by 13
Voelz, C., Habib, P., Köberlein, S., Beyer, C., & Slowik, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02210-y · Cited by 12
Ex vivo expansion of hematopoietic stem cells
Wang, Y., & Sugimura, R. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113599 · Cited by 14
Thomas, J., Zimmerlin, L., Huo, J. S., Considine, M., Cope, L., & Zambidis, E. T. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00135-1 · Cited by 13
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Clarke, B. E., Ziff, O. J., Tyzack, G. E., Petrić, M., Wang, Y., Klein, P., Smith, C. A., Hall, C. A., Helmy, A. E., Howell, M., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00773-1 · Cited by 14
Hanrath, A. T., Hatton, C. F., Gothe, F., Browne, C., Vowles, J., Leary, P., Cockell, S., Cowley, S. A., James, W., Hambleton, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1035532 · Cited by 10
Self-citationKishishita, S., Usui‐Ouchi, A., Ouchi, Y., Hata, Y., Ebihara, N., & Nakao, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011307 · Cited by 9
Tissue-resident macrophages and renal diseases: landscapes and treatment directions
Qu, Z., Chu, J., Jin, S., Yang, C., Zang, J., Zhang, J., Xu, D., & Cheng, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1548053 · Cited by 8
Wu, X., Ni, Y., Li, W., Yang, B., Yang, X., Zhu, Z., Zhang, J., Wu, X., Shen, Q., Liao, Z., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105556 · Cited by 9
Induced Pluripotent Stem Cell-Derived Monocytes/Macrophages in Autoinflammatory Diseases
Tanaka, T., Shiba, T., Honda, Y., Izawa, K., Yasumi, T., Saito, M. K., & Nishikomori, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870535 · Cited by 9
Karabova, M. K., del Ser‐Badia, A., Hedegaard, A., Washer, S. J., Baykam, Z., O'Brien, D. P., Vendrell, I., Hester, S., Fischer, R., Johnson, E., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71337 · Cited by 10
Self-citationШевелева, О. Н., Protasova, E., Nenasheva, T. A., Butorina, N. N., Melnikova, V. I., Gerasimova, T., Sakovnich, O., Kurinov, A. M., Grigor’eva, E. V., Medvedev, S. P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612868 · Cited by 8
In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
Hall‐Roberts, H., Daniel, E. D., James, W., Davis, J. B., & Cowley, S. A. (2021) · Journal of Visualized Experiments · doi:10.3791/62217-v · Cited by 8
Self-citationIn vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
Hall‐Roberts, H., Daniel, E. D., James, W., Davis, J. B., & Cowley, S. A. (2021) · Journal of Visualized Experiments · doi:10.3791/62217 · Cited by 13
Self-citationEmbryonic-Derived Myb− Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis
Jerkić, M., Litvack, M. L., Gagnon, S., Otulakowski, G., Zhang, H., Rotstein, O. D., Kavanagh, B. P., Post, M., & Laffey, J. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063190 · Cited by 7
Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. J., & Yöder, M. C. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24598 · Cited by 7
Early life high fructose exposure disrupts microglia function and impedes neurodevelopmentPreprint
Wang, Z., Lipshutz, A. B., Liu, Z.-L., Trzeciak, A. J., Miranda, I. C., de la Torre, C. M., Schild, T., Lazarov, T., Rojas, W. S., Saavedra, P. H. V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.14.553242 · Cited by 7
Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages
Pickering, S., Wilson, H., Bravo, E., Perera, M. R., Seow, J., Graham, C., Almeida, N., Fotopoulos, L., Williams, T., Moitra, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54458-w · Cited by 6
Blenkle, A., Geladaris, A., & Weber, M. S. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01647-w · Cited by 6
Goswami, Y., Baghel, A., Sharma, G., Sharma, P. K., Biswas, S., Yadav, R., Garg, P. K., Shalimar, S., & Tandon, R. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.102463 · Cited by 6
Production and Characterization of Human Macrophages from Pluripotent Stem Cells
Lopez‐Yrigoyen, M., May, A., Ventura, T., Taylor, H., Fidanza, A., Cassetta, L., Pollard, J. W., & Forrester, L. M. (2020) · Journal of Visualized Experiments · doi:10.3791/61038-v · Cited by 6
Schmied, V., Korkut-Demirbaş, M., Venturino, A., Maya-Arteaga, J. P., & Siegert, S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03366-x · Cited by 7
Organoid Models of Lymphoid Tissues
Bogoslowski, A., Ren, J., Quintard, C., & Penninger, J. M. (2025) · Organoids · doi:10.3390/organoids4020007 · Cited by 5
Hunter, C. R., & Hudson, J. E. (2025) · Current Cardiology Reports · doi:10.1007/s11886-025-02246-3 · Cited by 5
Baert, L., Rudy, S., Pellisson, M., Doll, T., Rocchetti, R., Kaiser, M., Mäser, P., & Müller, M. M. (2024) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011559 · Cited by 5
Abdin, S. M., Mansel, F., Hashtchin, A. R., Ackermann, M., Hansen, G., Becker, B., Kick, B., Pham, N., Dietz, H., Schaniel, C., et al. (2024) · Biofabrication · doi:10.1088/1758-5090/ad4744 · Cited by 4
Armesilla-Diaz, A., Arenaz-Callao, M. P., Ashby, C. A., Blanco, D., D’Oria, E., Garuti, H., Gómez, V., del Río, R. G., Martínez-Hoyos, M., Meiler, E., et al. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01613-24 · Cited by 4
A human pathophysiological 3D-bone marrow model reveals immune and stromal cell heterogeneity
Giannini, M., Campione, G., Torcq, L., Donadelli, S., Bencheikh, M., Bounaud, S., Jeanpierre, S., Geistlich, K., Maguer‐Satta, V., Lefort, S., et al. (2026) · Communications Biology · doi:10.1038/s42003-025-09433-6 · Cited by 4
Induced pluripotent stem cell (iPSC)-derived CAR-macrophages: new kids on the block
Zhu, F., Chen, Z., Yu, Y., Rao, L., Lin, G., Deng, J., & Yu, Q. (2026) · Experimental Hematology · doi:10.1016/j.exphem.2026.105384 · Cited by 4
Practical choice for robust and efficient differentiation of human pluripotent stem cells
Fang, M., Liu, L., Zhou, H., Li, Y., & Zheng, Y. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.752 · Cited by 4
Poulis, N., Martin, M., Hoerstrup, S. P., Emmert, M. Y., & Fioretta, E. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-62745-1 · Cited by 4
Hübschmann, V., Korkut-Demirbaş, M., & Siegert, S. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101866 · Cited by 5
A Comparative Study of Human Pluripotent Stem Cell-Derived Macrophages in Modeling Viral Infections
Zhang, Y., Qiu, H., Duan, F., An, H., Qiao, H., Zhang, X., Zhang, J., Ding, Q., & Na, J. (2024) · Viruses · doi:10.3390/v16040552 · Cited by 4
Mitochondria Clearance Enables Macrophage-Driven Maturation of iPSC-Derived Cardiomyocyte Metabolism
Ketchum, F., Celebi, L. E., Hawthorne, L., & Zorlutuna, P. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-026-00915-z · Cited by 3
Schilling, M., Vaughan-Jackson, A., James, W., & McKeating, J. A. (2023) · Journal of General Virology · doi:10.1099/jgv.0.001885 · Cited by 3
Self-citationCellular models in autoinflammatory disease research
Şen, B., & Balcı‐Peynircioğlu, B. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.1481 · Cited by 3
Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
Blümke, A., Simon, J., Leber, E., Scatena, M., & Giachelli, C. M. (2024) · Journal of Visualized Experiments · doi:10.3791/66527 · Cited by 3
Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineagePreprint
Lazarov, T., Loyher, P.-L., Yang, H., Choo, Z.-N., Deng, Z., Nowotschin, S., Kuo, Y.-Y., Zhou, T., Alberdi, A., Stumm, R. K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.24.609533 · Cited by 3
Integrating Macrophages into Human-Engineered Cardiac Tissue
Zhao, Y. P., & Fine, B. M. (2025) · Cells · doi:10.3390/cells14171393 · Cited by 2
Otero, A. M., & Antonson, A. M. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1677414 · Cited by 2
Characterization of the mammalian prodefinitive angio-hematopoietic lineage
Lazarov, T., Loyher, P.-L., Yang, H., Choo, Z.-N., Deng, Z., Nowotschin, S., Kuo, Y.-Y., Zhou, T., Alberdi, A., Stumm, R. K., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adt6616 · Cited by 5
Transcriptional Regulation of Macrophage Specification and Function
Vanneste, D., & Marichal, T. (2025) · European Journal of Immunology · doi:10.1002/eji.70097 · Cited by 3
Immune-stromal interactions at the crossroads of tissue injury, repair, and tumor progression
Ning, D., Tavakol, D. N., Graney, P. L., Lee, E., Hung, C. T., & Vunjak‐Novakovic, G. (2026) · Med · doi:10.1016/j.medj.2026.101222 · Cited by 2
In vitro systems to study inborn errors of immunity using human induced pluripotent stem cells
Nikolouli, E., Reichstein, J., Hansen, G., & Lachmann, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1024935 · Cited by 2
Peng, D., Li, M., Yu, Z., Yan, T., Meng, Y., Su, L., Liu, Z. H., Li, L., & Qiu, H. (2024) · Cell Proliferation · doi:10.1111/cpr.13770 · Cited by 2
Immunoregulatory iPSC-derived non-lymphoid progeny in autoimmunity and GVHD alloimmunity
Ma, L., Fink, J. N., Ke, Y., McDonald-Hyman, C. S., Dougherty, P., Koehn, B. H., & Blazar, B. R. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf011 · Cited by 2
Induced pluripotent stem cells to generate skin tissue models
Kashpur, O., Smith, A., Mukhamedshina, N., Baskin, J., Shamis, Y., Hewitt, K. J., Gerami‐Naini, B., & Garlick, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810545-0.00017-6 · Cited by 2
New Drugs for an Old Foe: Mycobacterium tuberculosis Meets PSC-Derived Macrophages
Haake, K., & Lachmann, N. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.11.006 · Cited by 2
Mechanisms Which Control the Size of M2 Macrophage-Dominated Tissue Macrophage Niches
Rőszer, T. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-50480-9_5 · Cited by 3
Suku, M., Murphy, J. F., Corbezzolo, S., Biggs, M. J. P., Forte, G., Turnbull, I. C., Costa, K. D., Forrester, L. M., & Monaghan, M. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.04.626684 · Cited by 2
Hetzel, M., Gensch, I., Ackermann, M., & Lachmann, N. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3437-0_31 · Cited by 1
hiPSC-Derived Gingival Epithelium-On-Chip for Modeling Inflammation and Immune Response
Zhou, Y., Liu, Y., Lin, X., An, J. Y., & Zhang, M. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c01623 · Cited by 1
Kim, D., Kondo, T., & Inoue, H. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102866 · Cited by 1
Olschewski, D. N., Koenig, A. M., Nerone, H. M., Groß, E., Šarić, T., Vay, S. U., Schroeter, M., Fink, G. R., & Rueger, M. A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1785992 · Cited by 1
McKee, C. M., Cranston, M., McKay, E. C., Arefian, M., Mawhinney, T. J., Collins, B. C., & Coll, R. C. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101506 · Cited by 1
Liu, X., Li, M., Wei, Z., Shang, T., & Zou, W. (2026) · ASN NEURO · doi:10.1080/17590914.2026.2687503 · Cited by 1
Modeling myeloid cell development in health and disease using induced pluripotent stem cells
Tesakov, I., Nasri, M., Klimiankou, M., Fındık, B., Loskill, P., & Skokowa, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1815809 · Cited by 1
Pluripotent Stem Cell Derived Macrophages: Current Applications and Future Perspectives
Jose, S. S., & Forrester, L. M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104514 · Cited by 1
FLT3 signaling augments macrophage production from human pluripotent stem cells
Kitajima, K., Shingai, M., Ando, H., & Hara, T. (2023) · International Immunology · doi:10.1093/intimm/dxad047 · Cited by 1
The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation
Kala, S., Strutz, A. G., & Katt, M. E. (2025) · Neurology International · doi:10.3390/neurolint17010006 · Cited by 2
Lim, Y., Cheong, S. K., & Leong, P. P. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10855-2 · Cited by 1
Stem Cell-Based Disease Models for Inborn Errors of Immunity
Zbinden, A., Canté-Barrett, K., Pike‐Overzet, K., & Staal, F. J. T. (2021) · Cells · doi:10.3390/cells11010108 · Cited by 1
An integrated analysis of myeloid cells identifies gaps in in vitro models of in vivo biologyPreprint
Rajab, N., Angel, P. W., Deng, Y., Gu, J. L., Jameson, V. J., Kurowska‐Stolarska, M., Milling, S. W. F., Pacheco, C. M., Rutar, M., Laslett, A. L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/719237 · Cited by 1
Li, F., Okreglicka, K. M., Pohlmeier, L. M., Schneider, C., & Köpf, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.04.447115 · Cited by 1
SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationPreprint
Moore, M. D., Johnson, E., Jacklin, C., Johnson, S., Green, O., & James, W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.25.505278 · Cited by 1
Self-citationDevelopmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissuePreprint
Song, A. T., Sindeaux, R., Li, Y., Affia, H., Agnihotri, T., Leclerc, S., Vliet, P. P. V., Colas, M., Guimond, J.-V., Patey, N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.09.505715 · Cited by 1
Bao, Q., Lim, C. Y., Tay, N. L., Yeo, H. L., Punyawai, K., Hsu, C., Chong, S. M., Xie, S., Loh, J. Y.-H., Ng, S. C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.02.722394 · Cited by 1
HIV-1 evasion of restriction factors: cyclophilin A and cell fusion provide a helping handPreprint
Owen, H., Vaughan-Jackson, A., Nußbaum, L., Vowles, J., James, W., & Moore, M. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/383075
Self-citationA chemical tool for improved culture of human pluripotent stem cellsPreprint
Silpa, L., Schuessler, M., Liu, G., Olivecrona, M., Groizard-Payeras, L., Couper, E., Bataille, C. J. R., Stevenson, M., Seymour, L. W., Davies, S. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.24.918268
Self-citationPluripotent Stem Cells and Reprogramming
Heslop, J. A., & Duncan, S. A. (2020) · doi:10.1002/9781119436812.ch80
Human induced pluripotent stem cells for modeling of Salmonella infection
Forbester, J. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823808-0.00009-2
Tümmler, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734570161.793563384
Kaufman, D. S., & Pouyanfard, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735967778.793563125
Sakaida, I., & Takami, T. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735895826.793568936
Proliferation drives quorum sensing of microbial products in human macrophage populationsPreprint
Rajab, N., Gearing, L. J., Lyu, R., Prawer, Y. D. J., Angel, P. W., Grimmond, S. M., Laslett, A. L., McCarthy, D. J., & Wells, C. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.12.491598
Schilling, M., Vaughan-Jackson, A., James, W., & McKeating, J. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.21.529434
Self-citationBaert, L., Rudy, S., Pellisson, M., Doll, T., Rocchetti, R., Kaiser, M., Mäser, P., & Müller, M. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.31.551225
Poulis, N., Martin, M., Hoerstrup, S. P., Emmert, M. Y., & Fioretta, E. S. (2024) · Research Square · doi:10.21203/rs.3.rs-3929294/v1
Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressorsPreprint
Strässler, E. T., Kessler, E. L., van Vliet, E. F., Chirico, N., Na, E., Cai, Q., van Mil, A., Schiattarella, G. G., Gerhardt, H., Kränkel, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.16.682827
Conventional and Alternative B Lymphopoiesis: Multiple Roads to Immunity
Chiron, A., Bessoles, S., Sarrabayrouse, G., Krzysiek, R., & Hacein‐Bey‐Abina, S. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10999-1 · Cited by 1
Nuesslein‐Hildesheim, B., Ferrero, E., Schmid, C., Huck, C., Smith, P. A., Tisserand, S., Rubert, J., Bornancin, F., Eichlisberger, D., & Cenni, B. (2023) · Figshare · doi:10.6084/m9.figshare.24038698
Ackermann, M., Saleh, F., Abdin, S. M., Hashtchin, A. R., Gensch, I., Golgath, J., Oliveira, C., Nguyen, A. H. H., Gaedcke, S., Fenske, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26735583
Zhang, P., Amarasinghe, H. E., Whalley, J. P., Tay, C., Fang, H., Migliorini, G., Brown, A., Allcock, A., Scozzafava, G., Rath, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20156800
Zhang, P., Amarasinghe, H. E., Whalley, J. P., Tay, C., Fang, H., Migliorini, G., Brown, A., Allcock, A., Scozzafava, G., Rath, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20156806
Ackermann, M., Saleh, F., Abdin, S. M., Hashtchin, A. R., Gensch, I., Golgath, J., Oliveira, C., Nguyen, A. H. H., Gaedcke, S., Fenske, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26735586
Ackermann, M., Saleh, F., Abdin, S. M., Hashtchin, A. R., Gensch, I., Golgath, J., Oliveira, C., Nguyen, A. H. H., Gaedcke, S., Fenske, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26735580
Ackermann, M., Saleh, F., Abdin, S. M., Hashtchin, A. R., Gensch, I., Golgath, J., Oliveira, C., Nguyen, A. H. H., Gaedcke, S., Fenske, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26054801
Metadata
- Authors
- Buchrieser, J., James, W., & Moore, M. D.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Buchrieser, Julian
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 8
- Issue
- 2
- Pages
- 334-345
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5312255
- OpenAlex
- W2575042032
- Cited by
- 215
- References
- 50
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 27 · 2023: 19 · 2022: 25 · 2021: 26 · 2020: 30 · 2019: 15 · 2018: 22 · 2017: 9
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Parkinson's UK (2581970, SC037554)
- Research Councils UK
- Wellcome Trust (WTISSF121302)
- National Institute for Health and Care Research (090532/Z/09/Z.)
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- tissue-resident macrophages, iPSC-derived macrophages, macrophage ontogeny, hematopoietic development, RUNX1, yolk sac macrophages, microglia, Kupffer cells, Langerhans cells, alveolar macrophages, kidney macrophages, monocytes, CRISPR/Cas9 knockout
- MeSH terms
- Proto-Oncogene Protein Spi-1, Cell Differentiation, Cell Line, Erythrocytes, Granulocytes, Hematopoietic Stem Cells, Humans, Macrophages, Monocytes, Organ Specificity, Phenotype, Proto-Oncogene Proteins, Biomarkers, Trans-Activators, Gene Expression, Gene Expression Regulation, Developmental, Genes, myb, Core Binding Factor Alpha 2 Subunit, Gene Knockout Techniques, Induced Pluripotent Stem Cells, Embryoid Bodies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
