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Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche

Apostolopoulou, Maria, Kiehl, Thomas R., Winter, Mark, Cardenas De La Hoz, Edgar, Boles, Nathan C., Bjornsson, Christopher S., Zuloaga, Kristen L., Goderie, Susan K., Wang, Yue, Cohen, Andrew R., Temple, Sally·2017·Stem Cell Reports

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Crossref · 10.1016/j.stemcr.2017.10.005

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6 of 6 references verified0 citation errors · 0 not checkable

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  • Levels of BMP2, 4, 6, and 7 expression increase in the hippocampus and SVZ with age.

    “Levels of BMP2, 4, 6, and 7 expression have been found to increase in the hippocampus and SVZ with age (Yousef et al., 2015; Apostolopoulou et al., 2017).”

    From Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model (2022) · cites this paper as Apostolopoulou et al., 2017

    The Results section on global V-SVZ transcriptome analysis reports age-related gene-expression changes, but does not identify increases in BMP2, BMP4, BMP6, or BMP7. The Introduction mentions the hippocampus without reporting BMP expression there. Searches for those BMPs and bone morphogenetic proteins found no passage addressing the claimed increase. (LLM, conf=0.76)

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Research works printed but not linked: 41

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Cited by

Sorted by citations

Metadata

Authors
Apostolopoulou, M., Kiehl, T. R., Winter, M., Cardenas De La Hoz, E., Boles, N. C., Bjornsson, C. S., Zuloaga, K. L., Goderie, S. K., Wang, Y., Cohen, A. R., & Temple, S.
Venue
Stem Cell Reports
Publisher
Elsevier BV
Published
2017-12
Volume
9
Issue
6
Pages
1931-1947
ISSN
2213-6711
Cited by
46
References
6
Language
en
Funders
  • NIA (5R01AG041861-03)
  • Ellison Medical Foundation (AG-SS-2655-11)
  • NYSTEM (C-029158)

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