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Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche
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Levels of BMP2, 4, 6, and 7 expression increase in the hippocampus and SVZ with age.
“Levels of BMP2, 4, 6, and 7 expression have been found to increase in the hippocampus and SVZ with age (Yousef et al., 2015; Apostolopoulou et al., 2017).”
From Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model (2022) · cites this paper as Apostolopoulou et al., 2017
The Results section on global V-SVZ transcriptome analysis reports age-related gene-expression changes, but does not identify increases in BMP2, BMP4, BMP6, or BMP7. The Introduction mentions the hippocampus without reporting BMP expression there. Searches for those BMPs and bone morphogenetic proteins found no passage addressing the claimed increase. (LLM, conf=0.76)
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Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model
Reinitz, F., Chen, E. Y., Nicolis di Robilant, B., Chuluun, B., Antony, J., Jones, R. C., Gubbi, N., Lee, K., Ho, W. H. D., Kolluru, S. S., et al. (2022) · eLife · doi:10.7554/elife.66037 · Cited by 18
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Self-citationVascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
Rojas-Vázquez, S., Blasco-Chamarro, L., López-Fabuel, I., Martínez-Máñez, R., & Fariñas, I. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666881 · Cited by 15
Zhao, X., Fisher, E. S., Wang, Y., Zuloaga, K., Manley, L., & Temple, S. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.007 · Cited by 10
Self-citation
Metadata
- Authors
- Apostolopoulou, M., Kiehl, T. R., Winter, M., Cardenas De La Hoz, E., Boles, N. C., Bjornsson, C. S., Zuloaga, K. L., Goderie, S. K., Wang, Y., Cohen, A. R., & Temple, S.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 9
- Issue
- 6
- Pages
- 1931-1947
- ISSN
- 2213-6711
- PMC
- PMC5785674
- Cited by
- 46
- References
- 6
- Language
- en
- Funders
- NIA (5R01AG041861-03)
- Ellison Medical Foundation (AG-SS-2655-11)
- NYSTEM (C-029158)
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