The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.
Histone methylation makes its mark on longevity
Open accessAbstract
How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity.
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“Increased histone H4K16 acetylation, H4K20 trimethylation or H3K4 trimethylation, as well as decreased H3K9 methylation or H3K27 trimethylation, constitute age-associated epigenetic marks (Fraga and Esteller, 2007; Han and Brunet, 2012).”
From The Hallmarks of Aging (2013) · cites this paper as Han and Brunet, 2012
Experimental — accuracy not yet measuredIn the citing paper
“For example, the ASH-2 trithorax complex mediates trimethylation of histone H3 on Lys4 (H3K4me3), and its deletion increases Caenorhabditis elegans lifespan, consistent with excessive H3K4me3 being associated with an aging epigenome172,173.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [173]
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Cites
1 retracted
Fasano, C. A., Dimos, J. T., Ivanova, N. B., Lowry, N. A., Lemischka, I. R., & Temple, S. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.04.001 · Cited by 308
RetractedChromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
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1 of the 93 references couldn’t be matched to a known paper.
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Items 201–204 of 204
Immunotherapy for senescent cell clearance: Hallmarks, strategies and translational challenges
Zhang, W., Chen, S., & Zhuang, X. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103174
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2026) · Biogerontology · doi:10.1007/s10522-026-10470-9
Hassan, Z. A., Dakik, H., Arreba-Tutusaus, P., Frey, F., Mantash, S., Mitchell, A., Boileau, M., Abelson, S., Kleit, M., Hayek, Z., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1814908
Metadata
- Authors
- Han, S., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 22
- Issue
- 1
- Pages
- 42-49
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC3253950
- OpenAlex
- W1968018974
- Cited by
- 204
- References
- 93
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 5 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 20 · 2017: 19 · 2016: 15 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 6
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute on Aging (R01-AG31198, R01AG031198)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone methylation, lifespan, longevity, epigenetic regulation, chromatin modification, H3K4me3, H3K27me3, chromatin regulators, healthspan, model organisms
- MeSH terms
- Animals, Chromatin, Histones, Humans, Longevity, Methylation, Phylogeny, Cellular Senescence
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