Cited by 204Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

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Histone methylation makes its mark on longevity

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Han, Shuo, Brunet, Anne·2012·Trends in Cell Biology

DOI 10.1016/j.tcb.2011.11.001PMC PMC3253950

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Abstract

How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity.

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Authors: Han, S., & Brunet, A.
Affiliations: Stanford University (US)
Corresponding author: Brunet, Anne
ORCID: Han, Shuo
Brunet, Anne
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2012-01
Volume: 22
Issue: 1
Pages: 42-49
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2011.11.001
PMC: PMC3253950
OpenAlex: W1968018974
Cited by: 204
References: 93
Citations by year: 2026: 5 · 2025: 14 · 2024: 5 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 20 · 2017: 19 · 2016: 15 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 6
FWCI: 1.34
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute on Aging (R01-AG31198, R01AG031198)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: histone methylation, lifespan, longevity, epigenetic regulation, chromatin modification, H3K4me3, H3K27me3, chromatin regulators, healthspan, model organisms
MeSH terms: Animals, Chromatin, Histones, Humans, Longevity, Methylation, Phylogeny, Cellular Senescence

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Histone methylation makes its mark on longevity

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