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Cited by 115Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Diversity Matters: A Revised Guide to Myelination

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Tomassy, Giulio Srubek, Dershowitz, Lori Bowe, Arlotta, Paola·2016·Trends in Cell Biology
DOI 10.1016/j.tcb.2015.09.002PMC PMC4727993
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Abstract

The evolutionary success of the vertebrate nervous system is largely due to a unique structural feature--the myelin sheath, a fatty envelope that surrounds the axons of neurons. By increasing the speed by which electrical signals travel along axons, myelin facilitates neuronal communication between distant regions of the nervous system. We review the cellular and molecular mechanisms that regulate the development of myelin as well as its homeostasis in adulthood. We discuss how finely tuned neuron-oligodendrocyte interactions are central to myelin formation during development and in the adult, and how these interactions can have profound implications for the plasticity of the adult brain. We also speculate how the functional diversity of both neurons and oligodendrocytes may impact on the myelination process in both health and disease.

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  • In OPCs, there was early upregulation of several transcription factors and Notch ligands known to regulate differentiation to oligodendrocytes after loss of surrounding oligodendrocytes.

    “In OPCs, there was early upregulation of several transcription factors (OLIG1, OLIG2, SOX10, SOX8, PRRX1, ASCL1) and Notch ligands (DLL1, DLL3) known to regulate differentiation78–81 to oligodendrocytes after loss of surrounding oligodendrocytes (Fig. 7e, right, and Fig. 7g).”

    From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [81]

    In ‘Getting started’ (page unavailable), the review identifies Olig2 as a regulator of oligodendrocyte differentiation and Sox10 as a differentiation-promoting gene. ‘Teamwork I’ (page unavailable) also describes Notch ligands as regulators of oligodendrocyte development. It does not establish that all the listed factors, including DLL1 and DLL3, regulate differentiation; nor does it report their early upregulation after loss of surrounding oligodendrocytes, which the citing sentence links to its own figures. (LLM, conf=0.85)

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Authors
Tomassy, G. S., Dershowitz, L. B., & Arlotta, P.
Affiliations
Harvard University (US)
Corresponding author
  • Tomassy, Giulio Srubek
  • Arlotta, Paola
ORCID
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2016-02
Volume
26
Issue
2
Pages
135-147
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/j.tcb.2015.09.002
PMC
PMC4727993
OpenAlex
W1842838667
Cited by
115
References
12
Citations by year
2026: 6 · 2025: 11 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 5 · 2017: 17 · 2016: 9 · 2015: 1
FWCI
1.33
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS078164)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
myelination, myelin sheath, oligodendrocytes, myelin homeostasis, adult brain plasticity, neuronal heterogeneity
MeSH terms
Adult, Animals, Axons, Biological Evolution, Humans, Myelin Sheath, Synaptic Transmission, Neurons, Oligodendroglia

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