Cited by 860Metabolism, Diabetes, and CancerBiochemical and Molecular ResearchPI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

Open access

Hardie, D. Grahame, Schaffer, Bethany E., Brunet, Anne·2016·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.10.013PMC PMC5881568

Open this paper in CoChat — free account Open PDF

Abstract

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide-dependent mechanism that activates AMPK when cellular energy status is compromised, as well as other, noncanonical activation mechanisms. Once activated, AMPK acts to restore energy homeostasis by promoting catabolic pathways, resulting in ATP generation, and inhibiting anabolic pathways that consume ATP. We also review the various hypothesis-driven and unbiased approaches that have been used to identify AMPK substrates and have revealed substrates involved in both metabolic and non-metabolic processes. We particularly focus on methods for identifying the AMPK target recognition motif and how it can be used to predict new substrates.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tcb.2015.10.013

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

WebLogo: A Sequence Logo Generator: Figure 1Preprint
Crooks, G. E., Hon, G. C., Chandonia, J., & Brenner, S. E. (2004) · Genome Research · doi:10.1101/gr.849004 · Cited by 12,418
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
FIMO: scanning for occurrences of a given motif
Grant, C. E., Bailey, T. L., & Noble, W. S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr064 · Cited by 4,247
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs
Obenauer, J. C. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg584 · Cited by 1,609
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
Yaffe, M. B., Rittinger, K., Volinia, S., Caron, P. R., Aitken, A., Leffers, H. C. B., Gamblin, S. J., Smerdon, S. J., & Cantley, L. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80487-0 · Cited by 1,604
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589
Self-citation

Flagged first, then by citations

Show all 75 references

Sorted by citations

Items 601–700 of 860

Salient Features for Designing a Functional Beverage Formulation to Boost Energy
Swaroop, A., Bagchi, M., Moriyama, H., & Bagchi, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805413-0.00025-9 · Cited by 8
Sex-dimorphic Rostro-caudal Patterns of 5′-AMP-activated Protein Kinase Activation and Glucoregulatory Transmitter Marker Protein Expression in the Ventrolateral Ventromedial Hypothalamic Nucleus (VMNvl) in Hypoglycemic Male and Female Rats: Impact of Estradiol
Alshamrani, A. A., Bheemanapally, K., Alhamyani, A., Ali, M. H., Napit, P. R., Uddin, M. M., Mahmood, A. S. M. H., Ibrahim, M. M. H., & Briski, K. P. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01730-5 · Cited by 8
LKB1 regulates autophagy through AMPK/TOR signaling pathway to alleviate the damage caused by Vibrio alginolyticus infection
Yin, X., Zhuang, X., Luo, W., Liao, M., Huang, L., Cui, Q., Huang, J., Yan, C., Jiang, Z., Liu, C., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130470 · Cited by 7
Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat
Sapkota, S., Roy, S. C., Shrestha, R., & Briski, K. P. (2024) · ASN NEURO · doi:10.1080/17590914.2024.2368382 · Cited by 7
Heat Hardening Ameliorates Apoptotic and Inflammatory Effects Through Increased Autophagy in Mussels
Georgoulis, I., Giantsis, I. Α., Michaelidis, B., & Feidantsis, K. G. (2024) · Marine Biotechnology · doi:10.1007/s10126-024-10371-3 · Cited by 7
The Effects of Warm Acupuncture on the Expression of AMPK in High-Fat Diet-Induced MAFLD Rats
Lee, Y., Choi, D., Park, J., Kim, J. G., Choi, T., & Youn, D. H. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46100687 · Cited by 7
Mechanisms underlying phenotypic plasticity in response to environmental change
Seebacher, F., & Little, A. G. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70100 · Cited by 9
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1
Xu, M., Lin, X., Xu, H., Hu, H., Xue, X., Zhang, Q., Yu, D., Tian, S., Xie, M., Li, L., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci197592 · Cited by 8
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites
Negoita, F., Bringas, C. F., Hellberg, K., Luda, K. M., Liu, H., Li, Z., Cuenco, J., Zhao, J., Sathe, G. J., Ganley, I. G., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2629720 · Cited by 7
Glucose transporter 1 deficiency, AMP-activated protein kinase activation and immune dysregulation in autism spectrum disorder: Novel biomarker sources for clinical diagnosis
Al-Bishri, W. M. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103849 · Cited by 7
The SIK3-N783Y mutation is associated with the human natural short sleep trait
Chen, H., Ye, X., Wan, C., Zhang, Z., Shi, Z., Liang, Y., Jin, C., Chen, Y., Xia, Z., Xu, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500356122 · Cited by 10
Expression, purification and characterization of the plant Snf1-related protein kinase 1 from Escherichia coli
Zhao, R. (2019) · Protein Expression and Purification · doi:10.1016/j.pep.2019.05.007 · Cited by 7
Characterization of an aryl piperazine/2-hydroxypropyl-β-cyclodextrin association, a complex with antidiabetic potential
Devine, R., Martin, D. S. D., Kinsella, G. K., Findlay, J. B. C., & Stephens, J. C. (2020) · Results in Chemistry · doi:10.1016/j.rechem.2020.100026 · Cited by 7
Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology
Wang, T., Li, Z., Yan, L., Yan, F., Shen, H., & Tian, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.783526 · Cited by 7
Endothelial DLL4 Is an Adipose Depot–Specific Fasting Sensor Regulating Fatty Acid Fluxes
Aupetit, A., Decaunes, P., Belles, C., Riant, É., Galitzky, J., Chapouly, C., Laisné, M., Florès-Florès, R., Chaput, B., Vié, K., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318876 · Cited by 7
Astaxanthin improves fatty acid dysregulation in diabetes by controlling the AMPK-SIRT1 pathway
Taghiyar, S., Pourrajab, F., & Aarabi, M. H. (2023) · EXCLI journal · doi:10.17179/excli2023-6132 · Cited by 7
Berberine and aspirin prevent traumatic heterotopic ossification by inhibition of BMP signalling pathway and osteogenic differentiation
Fan, J., Gao, J., Chen, J., Hou, J., Liu, M., Dang, Y.-M., & Lin, H. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17919 · Cited by 5
Plumbagin alleviates obesity‐related asthma: Targeting inflammation, oxidative stress, and the AMPK pathway
Zhang, L., Liang, D., Liu, L., & Liu, L. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.1025 · Cited by 7
Glucose regulates MafA transcription factor abundance and insulin gene expression by inhibiting AMP-activated protein kinase in pancreatic β-cells
Iwaoka, R., & Kataoka, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.817932 · Cited by 7
Retracted
Manipulation and Measurement of AMPK Activity in Pancreatic Islets
Martínez-Sánchez, A., Nguyen‐Tu, M., Leclerc, I., & Rutter, G. A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_26 · Cited by 8
Surviving Starvation: AMPK Protects Germ Cell Integrity by Targeting Multiple Epigenetic Effectors
Demoinet, É., & Roy, R. (2018) · BioEssays · doi:10.1002/bies.201700095 · Cited by 8
Integrated analysis of microRNA and mRNA interactions regulating fecundity in the ovaries of two distinct sheep breeds
Yousuf, S., Malik, W. A., Feng, H., Liu, T., Xie, L., & Miao, X. (2025) · BMC Genomics · doi:10.1186/s12864-025-11408-0 · Cited by 6
Pyrroloquinoline quinone supplemented diet enhances metabolism, feed intake and growth in common carp (Cyprinus carpio Linnaeus, 1758) reared at low temperature
Radhakrishnan, G., Deo, A. D., Shamna, N., Mondal, A., Aklakur, M., Varghese, E., & Sahu, N. P. (2022) · Indian Journal of Fisheries · doi:10.21077/ijf.2022.69.3.113674-09 · Cited by 6
Neuroprotective Effects of Metformin Through AMPK Activation in a Neurotoxin-Based Model of Cerebellar Ataxia
Atella, T. C., Medina, J. M., Atella, G. C., Allodi, S., & Kluck, G. E. G. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03892-w · Cited by 6
Microcystin-RR promote lipid accumulation through CD36 mediated signal pathway and fatty acid uptake in HepG2 cells.
Jia, W., Zhong, L., Ren, Q., Teng, D., Gong, L., Dong, H.-B., Li, J., Wang, C.-X., He, Y., & Yang, J. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118402 · Cited by 6
Therapeutic Potential of Natural Compounds in Subarachnoid Haemorrhage
Tan, J., Zhu, H., Zeng, Y., Li, J., Zhao, Y., & Li, M. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.03.032 · Cited by 6
The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy
He, S., Luo, C., Shi, F., Zhou, J., & Shang, L. (2024) · Biology · doi:10.3390/biology13070543 · Cited by 6
The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions
Wang, H., Lv, C., Feng, L., Guo, J., Zhao, S., & Jiang, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38959 · Cited by 7
Treatment with Pterostilbene Ameliorates the Antioxidant Status of Bovine Spermatozoa and Modulates Cell Death Pathways
Chavas, C., Sapanidou, V., Feidantsis, K. G., Lavrentiadou, S. N., Mavrogianni, D., Zarogoulidou, I., Fletouris, D. J., & Tsantarliotou, M. P. (2024) · Antioxidants · doi:10.3390/antiox13121437 · Cited by 6
Reserpine treatment activates AMP activated protein kinase (AMPK)
Park, R., Lee, K. I., Kim, H., Jang, M., Ha, T. K. Q., Oh, W. K., & Park, J. (2017) · Natural Product Sciences · doi:10.20307/nps.2017.23.3.157 · Cited by 6
Chronic Activation of AMPK Induces Mitochondrial Biogenesis through Differential Phosphorylation and Abundance of Mitochondrial Proteins in Dictyostelium discoideum
Czarna, M., Heidorn, H., Fernando, S., Sanislav, O., Jarmuszkiewicz, W., Mutzel, R., & Fisher, P. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111675 · Cited by 7
Transcriptome Analysis Reveals MAPK/AMPK as a Key Regulator of the Inflammatory Response in PST Detoxification in Mytilus galloprovincialis and Argopecten irradians
Dong, C., Wu, H., Zheng, G., Peng, J., Guo, M., & Tan, Z. (2022) · Toxins · doi:10.3390/toxins14080516 · Cited by 6
Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity
Dominici, C., Villarreal, O. D., Dort, J., Heckel, É., Wang, Y. C., Ragoussis, I., Joyal, J., Dumont, N. A., & Richard, S. (2023) · eLife · doi:10.7554/elife.84570 · Cited by 7
WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes
Wang, Y., Zhang, Y., Wang, Y., Han, P., Jian, R., Zhang, Z., Wang, S., & Li, Z. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1336923 · Cited by 6
Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns
Khabaz, M. N., Abdelrahman, A. S., & Al-Maghrabi, J. A. (2019) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.35.3.159 · Cited by 6
Mechanical Postconditioning Promotes Glucose Metabolism and AMPK Activity in Parallel with Improved Post-Ischemic Recovery in an Isolated Rat Heart Model of Donation after Circulatory Death
Arnold, M., Méndez‐Carmona, N., Gulac, P., Wyss, R. K., Rutishauser, N., Segiser, A., Carrel, T. P., & Longnus, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030964 · Cited by 6
Changes in the Concentration of Purine and Pyridine as a Response to Single Whole-Body Cryostimulation
Dudzińska, W., & Lubkowska, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.634816 · Cited by 6
Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway
Pesi, R., Allegrini, S., Garcia‐Gil, M., Piazza, L., Moschini, R., Jordheim, L. P., Camici, M., & Tozzi, M. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137004 · Cited by 6
Plausible Links Between Metabolic Networks, Stem Cells, and Longevity
Kucia, M., & Ratajczak, M. Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-31206-0_15 · Cited by 6
DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia
Akimoto, R., Tanaka, T., Nakano, T., Hozumi, Y., Kawamae, K., & Goto, K. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109618 · Cited by 6
Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics
Urra, F. A., Fuentes-Retamal, S., Palominos, C., & Araya‐Maturana, R. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91095-8.00006-4 · Cited by 6
CDK4, a new metabolic sensor that antagonizes AMPK
Fajas, L., & López‐Mejía, I. C. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1409862 · Cited by 7
Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
Ata, R., & Antonescu, C. N. (2021) · doi:10.32920/14639496.v1 · Cited by 6
RyR1 Is Involved in the Control of Myogenesis
Tourel, A., Reynaud-Dulaurier, R., Brocard, J., Fauré, J., Marty, I., & Petiot, A. (2025) · Cells · doi:10.3390/cells14030158 · Cited by 5
AMPK: an enzyme that may be effective in cancer and metabolic diseases
Güney-Kalkan, S., & Ceylan‐Ünlüsoy, M. (2025) · Discover Oncology · doi:10.1007/s12672-025-02229-4 · Cited by 5
Natural products as modulators of ferroptosis: Therapeutic implications and molecular mechanisms in disease treatment
Tong, W. N., Mu, X., Xu, H., & Yin, X. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110259 · Cited by 5
CRISPR/Cas9-mediated mstnb knockout enhances muscle growth in salt-tolerant tilapia
Yang, Z., Le, W., Sun, F., Wong, J. E. L., Lee, M., & Yue, G. H. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743829 · Cited by 5
AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience
do Nascimento, I. B., Ates, G., Desmet, N., Beckers, P., Massie, A., & Hermans, E. (2023) · Biomolecules · doi:10.3390/biom13081183 · Cited by 5
Glucose transporter-2 regulation of VMN GABA neuron metabolic sensor and transmitter gene expression
Roy, S. C., Sapkota, S., Pasula, M. B., Katakam, S., Shrestha, R., & Briski, K. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-64708-y · Cited by 5
Will AMPK be a potential therapeutic target for hepatocellular carcinoma?
Chen, G. (2024) · American Journal of Cancer Research · doi:10.62347/yavk1315 · Cited by 5
AMPK-mediated regulation of cardiac energy metabolism: Implications for thermotolerance in Argopecten irradians irradians
Chang, J., Zhang, J., Chu, L., Liu, A., Hou, X., Zhu, X., Huang, X., Xing, Q., Hu, J., & Bao, Z. (2024) · Gene · doi:10.1016/j.gene.2024.148922 · Cited by 7
GSNOR plays roles in growth, pathogenicity, and stress resistance by modulating mitochondrial protein COX6B S-nitrosylation in Colletotrichum gloeosporioides
Yang, X. Y., Yang, Y., Wang, A., Zhao, Z., Luo, H., An, B., & Wang, Q. (2025) · mBio · doi:10.1128/mbio.01269-25 · Cited by 5
Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats
Contreras, J. M. D. L. M., Mailloux‐Salinas, P., Colado‐Velázquez, J. I., Gómez-Viquez, N. L., Velázquez‐Espejel, R., Notario, A. D. C. S., Arias‐Chávez, D. J., & Bravo, G. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10357 · Cited by 5
Phosphorylated AMP-activated protein kinase expression is significantly associated with poor clinical outcomes in bladder carcinoma patients.
Al-Maghrabi, J. A., Qureshi, I. A., Butt, N. S., & Khabaz, M. N. (2018) · Europe PMC (PubMed Central) · Cited by 5
Mitochondrial Effects on Seeds of Cancer Survival in Leukemia
El-Shaqanqery, H. E., Mohamed, R. H., & Sayed, A. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.745924 · Cited by 7
Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State
Wang, X., Schepler, H., Neufurth, M., Wang, S., Schröder, H. C., & Müller, W. E. G. (2022) · Progress in molecular and subcellular biology · doi:10.1007/978-3-031-01237-2_4 · Cited by 5
AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury
Michel‐Flutot, P., Efthimiadi, L., Djerbal, L., Deramaudt, T. B., Bonay, M., & Vinit, S. (2022) · Antioxidants · doi:10.3390/antiox11091665 · Cited by 5
Negative Cross-Talk between TLR2/4-Independent AMPKα1 and TLR2/4-Dependent JNK Regulates S. pneumoniae–Induced Mucosal Innate Immune Response
Matsuyama, S., Komatsu, K., Lee, B.-C., Tasaki, Y., Miyata, M., Xu, H., Shuto, T., Kai, H., & Li, J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100901 · Cited by 5
Effects of glucose availability on αS1-casein synthesis in bovine mammary epithelial cells
Sun, M., Li, Z., Xing, Y., Mu, X., Cao, Y., Hao, Y., Yang, J., & Li, D. (2022) · Journal of Animal Science · doi:10.1093/jas/skac330 · Cited by 5
A Rapid Alkalinization Factor-like Peptide EaF82 Impairs Tapetum Degeneration during Pollen Development through Induced ATP Deficiency
Hung, C., Kittur, F. S., Wharton, K. N., Umstead, M. L., Burwell, D. B., Thomas, M., Qi, Q., Zhang, J., Oldham, C. E., Burkey, K. O., et al. (2023) · Cells · doi:10.3390/cells12111542 · Cited by 5
Phosphorylation: new star of pathogenesis and treatment in steatotic liver disease
Lv, T.-S., Lou, Y., Yan, Q., Nie, L., Cheng, Z., & Zhou, X. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02037-9 · Cited by 6
Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis
Hilwi, M., Shulman, K., Naroditsky, I., Feld, S., Gross-Cohen, M., Boyango, I., Soboh, S., Vornicova, O., Farhoud, M., Singh, P., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06596-8 · Cited by 5
Conceptualizing Eukaryotic Metabolic Sensing and Signaling
Laxman, S. (2017) · Journal of the Indian Institute of Science · doi:10.1007/s41745-016-0013-1 · Cited by 5
Insulin normalized brain metabolic status on a Model of Anorexia Nervosa in Mice
Avraham, Y., Heukelom, B. V., Zolotarev, O., Magen, I., Vorobiev, L., & Zwas, D. R. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113738 · Cited by 5
Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion
Briski, K. P., Napit, P. R., Alhamyani, A., Leprince, J., & Mahmood, A. S. M. H. (2023) · ASN NEURO · doi:10.1177/17590914231167230 · Cited by 5
Analyzing AMPK Function in the Hypothalamus
Seoane‐Collazo, P., & López, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_27 · Cited by 5
The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension
Sidorenko, D. A., Lvova, I. D., Tyganov, S. A., Shenkman, B. S., & Sharlo, K. A. (2025) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-025-09700-3 · Cited by 5
Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation
Abdel-Rahman, R. F., Alsugoor, M. H., Alsuhaymi, N., Fayed, H. M., Mahmoud, S. S., Ibrahim, F. A., & Elbaset, M. A. (2025) · Saudi Pharmaceutical Journal · doi:10.1007/s44446-025-00039-x · Cited by 4
Coenzyme Q10 ameliorates obesity by promoting white adipose tissue browning and preserving mitochondrial dynamics in ovariectomized rats fed a high-fat diet
Pan, T., Chen, S., Kung, C.-W., Chen, H.-Y., Cheng, P., Shen, H., Shyu, I., & Lee, Y. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110187 · Cited by 4
Sulforaphane Against the Metabolic Consequences of a High-Glycemic-Index Diet: Protective and Therapeutic Mechanisms Associated with Obesity and Insulin Resistance
Çubuk, M., Pinar, A. A., Süleyman, B., & Taş, N. G. (2026) · Nutrients · doi:10.3390/nu18040574 · Cited by 5
Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease
Ariyath, A., Mputhia, Z., Dougherty, C., Rahuman, B. K., Fernando, W. M. A. D. B., Brown, B. M., Gardener, S. L., Rainey‐Smith, S. R., Martins, R. N., & Bharadwaj, P. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71191 · Cited by 4
B-Type Trimeric Procyanidins Attenuate Nonalcoholic Hepatic Steatosis Through AMPK/mTOR Signaling Pathway in Oleic Acid-Induced HepG2 Cells and High-Fat Diet- Fed Zebrafish
Tie, F., Gao, Y., Ren, L., Wu, Y., Hu, N., Dong, Q. Z., & Wang, H. (2025) · Plant Foods for Human Nutrition · doi:10.1007/s11130-024-01262-y · Cited by 4
Systems modeling and uncertainty quantification of AMP-activated protein kinase signaling
Linden-Santangeli, N. J., Zhang, J., Krämer, B., & Rangamani, P. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00588-w · Cited by 4
AMPK restricts HHV-6A replication by inhibiting glycolysis and mTOR signaling
Yang, X., Tian, S., Min, Z., Garbarino, E., Ma, J., Jia, J., Tang, H., & Li, L. (2024) · Virology · doi:10.1016/j.virol.2024.110080 · Cited by 4
Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism
Hsiung, K. C., Tang, H.-Y., Cheng, M., Hung, L., Tan, B. C., & Lo, S. J. (2024) · Biomedical Journal · doi:10.1016/j.bj.2024.100806 · Cited by 4
Experimentally-driven mathematical model to understand the effects of matrix deprivation in breast cancer metastasis
Maiti, S., Rangarajan, A., & Kareenhalli, V. V. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00443-4 · Cited by 5
Astrocyte glucose-6-phosphatase-Beta regulates ventromedial hypothalamic nucleus glucose counterregulatory neurotransmission and systemic hormone profiles
Briski, K. P., Katakam, S., Sapkota, S., Pasula, M. B., Shrestha, R., & Vadav, R. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102519 · Cited by 4
Insight into cyclodextrin hybrid framework formation mechanism to develop a universal vehicle for improving mitochondrial homeostasis
Lv, D., Liu, J.-H., Xu, H., Tao, X., Zhang, N., Guan, Y., & Zheng, L. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162926 · Cited by 4
Remote control of AMPK via extracellular adenosine controls tissue growth
Zhang, Y., Straßburger, K., & Teleman, A. A. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01764-0 · Cited by 4
Fasting improves tolerance to acute hypoxia in rats
Yue, X.-Y., Wang, X., Zhao, R., Jiang, S., Zhou, X., Jiao, B., Zhang, L., & Yu, Z. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.099 · Cited by 4
Influence and efficiency of an anti-diabetic drug Metformin hydrochloride as an uncoupler: Reducing sludge production
Li, J., & Tabassum, S. (2021) · Cleaner Engineering and Technology · doi:10.1016/j.clet.2021.100203 · Cited by 4
AMPK Activation Enhances Neutrophil's Fungicidal Activity in Vitro and Improves the Clinical Outcome of Fusarium solani Keratitis in Vivo
Si, W., Xie, Y., Dong, J., Wang, C., Zhang, F., Yue, J., Jian, S., Wei, J., Liu, S., Wang, L., et al. (2022) · Current Eye Research · doi:10.1080/02713683.2022.2078494 · Cited by 4
Anti-inflammatory Effect by Cloves Treatment in LPS-induced RAW264.7 Cells
Seo, S.-W., Kim, K., & Shin, M.-R. (2023) · Pharmacognosy Magazine · doi:10.1177/09731296221137420 · Cited by 4
Fetal lung hypoxia and energetic cell failure in the nitrofen-induced congenital diaphragmatic hernia rat model
Romero‐Lopez, M., Oria, M., Ferrer‐Marquez, F., Varela, M. F., Lampe, K., Watanabe‐Chailland, M., Martínez, L., & Peiro, J. L. (2023) · Pediatric Surgery International · doi:10.1007/s00383-023-05452-8 · Cited by 4
Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes to islet β-cell apoptosis and dysfunction
Li, M.-Y., Liu, L., Xin, Q., Zhou, J., Zhang, X., Zhang, R., Wu, Z., Yi, J., & Dong, M. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159332 · Cited by 4
Interplay Between Nutrient-Sensing Molecules During Aging and Longevity
Hadem, I. K. H., Majaw, T., & Sharma, R. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_18 · Cited by 4
Chitosan Oligosaccharide Inhibits the Synthesis of Milk Fat in Bovine Mammary Epithelial Cells through AMPK-Mediated Downstream Signaling Pathway
Fan, J., Chen, J., Haochen, W., Lu, X., Fang, X., Yin, F., Zhao, Z., Jiang, P., & Yu, H. (2022) · Animals · doi:10.3390/ani12131692 · Cited by 4
AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironmentPreprint
Lorenz, N. I., Sauer, B., Zeiner, P. S., Strecker, M. I., Luger, A., Schulte, D., Mittelbronn, M. G. A., Alekseeva, T., Sevenich, L., Harter, P. N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.25.485624 · Cited by 4
LdAMPKα2 knockdown accelerated the growth but depressed the chitin biosynthesis in Lymantria dispar larvae
Wang, Z., Wang, Z., & Zou, C. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.106198 · Cited by 3
Fluoride-induced Neurodevelopmental Toxicity- AMPK as a Possible Target
Ahuja, T. N., Begum, F., Beegum, F., Kumar, G., Kumar, N., & Shenoy, R. R. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273300345250206084817 · Cited by 3
Unravelling the Adiponectin Hallmark and Exploring the Therapeutic Potential of Its Receptor Agonists in Cancer Metabolic Reprogramming
Kafeel, S., Palmiero, G., Salzillo, A., Ragone, A., Naviglio, S., & Sapio, L. (2025) · Biomolecules · doi:10.3390/biom15060820 · Cited by 3
Implications of ferritinophagy in cardiovascular diseases and its pharmacological modulation: underlying mechanisms and clinical translation strategies
Wu, Y.-L., Xiao, L., Li, H.-N., & Chen, L. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-026-00941-9 · Cited by 4
The expression spectrum of yak epididymal epithelial cells reveals the functional diversity of caput, corpus and cauda regions
Pan, M., Luo, X., Zhang, Z., Li, J., Shahzad, K., Danba, Z., Caiwang, G., Chilie, W., Chen, X., & Zhao, W. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110912 · Cited by 3
Protective Role of Cepharanthine Against Equid Herpesvirus Type 8 Through AMPK and Nrf2/HO-1 Pathway Activation
Li, S., Li, L., Sun, Y., Khan, M. Z., Yu, Y., Ruan, L., Chen, L., Zhao, J., Jia, J., Li, Y., et al. (2024) · Viruses · doi:10.3390/v16111765 · Cited by 3
Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery
Behera, S., & Ghosh‐Roy, A. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0124-25.2026 · Cited by 3
Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial
Toda, K. (2016) · Integrative Molecular Medicine · doi:10.15761/imm.1000215 · Cited by 3
Oligopeptide Competition Assay for Phosphorylation Site Determination
Joo, M. S., Koo, J. H., Shin, S., Yim, H., & Kim, S. G. (2017) · Journal of Visualized Experiments · doi:10.3791/55708 · Cited by 3
Biophysical Interactions of Direct AMPK Activators
Kurumbail, R. G., West, G. M., Dharmarajan, V., Borzilleri, K. A., Withka, J. M., Ward, J., Reyes, A. R., Rajamohan, F., Griffin, P. R., & Calabrese, M. F. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_3 · Cited by 3
Schistosome AMPK Is Required for Larval Viability and Regulates Glycogen Metabolism in Adult Parasites
Hunter, K. S., Miller, A., Mentink‐Kane, M. M., & Davies, S. J. A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.726465 · Cited by 3
El papel de los azúcares como moléculas de señalización en las plantas
Hernández-Bernal, A. F., Gregorio-Jorge, J., & León, P. (2022) · TIP Revista Especializada en Ciencias Químico-Biológicas · doi:10.22201/fesz.23958723e.2022.519 · Cited by 4

Authors: Hardie, D. G., Schaffer, B. E., & Brunet, A.
Affiliations: University of Dundee (GB)
Stanford University (US)
Corresponding author: Hardie, D. Grahame
ORCID: Hardie, D. Grahame
Brunet, Anne
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2016-03
Volume: 26
Issue: 3
Pages: 190-201
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.10.013
PMC: PMC5881568
OpenAlex: W2174118934
Cited by: 859
References: 75
Citations by year: 2026: 41 · 2025: 62 · 2024: 80 · 2023: 69 · 2022: 89 · 2021: 112 · 2020: 97 · 2019: 77 · 2018: 103 · 2017: 80 · 2016: 46
FWCI: 7.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 353 d)
Locations: Trends in Cell Biology (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Discovery Research Portal (University of Dundee) (submittedVersion, cc-by-nc-nd)
Funders: Wellcome Trust (097726)
Cancer Research UK (C37030/A15101)
CIRM (RB4-06087)
NIH (R01 AG031198, T32 CA09302)
NSF GRFP
Robert M. and Anne T. Bass Stanford Graduate Fellowship
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: AMPK, AMPK activation, energy homeostasis, catabolic pathways, ATP production, substrate recognition motif, substrate prediction
MeSH terms: Allosteric Regulation, Amino Acid Sequence, Animals, Energy Metabolism, Enzyme Activation, Humans, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Catalytic Domain, AMP-Activated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks