AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

WebLogo: A Sequence Logo Generator: Figure 1Preprint

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Resveratrol improves health and survival of mice on a high-calorie diet

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FIMO: scanning for occurrences of a given motif

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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Contrasting views on the role of AMPK in autophagy

Kim, D. (2024) · BioEssays · doi:10.1002/bies.202300211 · Cited by 46

Differential Responses of Plants to Biotic Stress and the Role of Metabolites

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AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages

Kirchner, J., Brüne, B., & Namgaladze, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-26102-3 · Cited by 34

Sea Cucumber Peptides Improved the Mitochondrial Capacity of Mice: A Potential Mechanism to Enhance Gluconeogenesis and Fat Catabolism during Exercise for Improved Antifatigue Property

Yu, Y., Wu, G., Jiang, Y., Li, B., Feng, C., Ge, Y., Han, L., Jiang, L., Liu, H., Shi, Y., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4604387 · Cited by 34

SnRK1A ‐mediated phosphorylation of a cytosolic ATPase positively regulates rice innate immunity and is inhibited by Ustilaginoidea virens effector SCRE1

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Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance

Gugliucci, A. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.05.026 · Cited by 35

Altered Mitochondrial Signalling and Metabolism in Cancer

Chattopadhyay, E., & Roy, B. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00043 · Cited by 36

Energetic, antioxidant, inflammatory and cell death responses in the red muscle of thermally stressed Sparus aurata

Feidantsis, K. G., Georgoulis, I., Zachariou, A., Campaz, B., Christoforou, M., Pörtner, H., & Michaelidis, B. (2020) · Journal of Comparative Physiology B · doi:10.1007/s00360-020-01278-1 · Cited by 33

Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases

Lashgari, N., Roudsari, N. M., Momtaz, S., Ghanaatian, N., Kohansal, P., Farzaei, M. H., Afshari, K., Sahebkar, A., & Abdolghaffari, A. H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200504081503 · Cited by 39

Magnesium isoglycyrrhizinate prevents the nonalcoholic hepatic steatosis via regulating energy homeostasis

Jiang, W., Xu, S., Guo, H., Lu, L., Liu, J., Wang, G., & Hao, K. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15230 · Cited by 33

Signaling Pathways Involved in Nutrient Sensing Control in Cancer Stem Cells: An Overview

Robles‐Flores, M., Moreno-Londoño, Á. P., & Castañeda‐Patlán, M. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.627745 · Cited by 35

Ventromedial hypothalamic nucleus glycogen regulation of metabolic-sensory neuron AMPK and neurotransmitter expression: role of lactate

Bheemanapally, K., Ibrahim, M. M. H., Alshamrani, A. A., & Briski, K. P. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00292.2020 · Cited by 33

Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation

Kazyken, D., Lentz, S. I., & Fingar, D. C. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101100 · Cited by 34

Lipid metabolism–related lncRNA SLC25A21‐AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c‐Myc axis and SLC25A21 expression

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Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus

Liu, Y., Wang, D., & Yang, L. (2022) · Current Drug Targets · doi:10.2174/1389450123666220429082702 · Cited by 35

AMPK-independent inhibition of human macrophage ER stress response by AICAR

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Metabolic Regulation in Mitochondria and Drug Resistance

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The Energy Sensor AMPK: Adaptations to Exercise, Nutritional and Hormonal Signals

Viollet, B. (2017) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-72790-5_2 · Cited by 34

Anti-inflammatory Property of AMP-activated Protein Kinase

Noor, H. B., Mou, N. A., Salem, L., Shimul, M. F. A., Biswas, S., Akther, R., Khan, S., Raihan, S., Mohib, M. M., & Sagor, M. A. T. (2019) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523018666190830100022 · Cited by 34

Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01

Xia, J., Jiang, S., Lv, L., Wu, W., Wang, Q., Xu, Q., Ye, J., Fang, D., Li, Y., Wu, J., et al. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11099-z · Cited by 35

Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway

Shu, X., Cao, K.-Y., Liu, H., Yu, L., Sun, L., Yang, Z., Wu, C., & Ran, Y. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02160-9 · Cited by 33

A comprehensive review on glucokinase activators: Promising agents for the treatment of Type 2 diabetes

Thilagavathi, R., Hosseini‐Zare, M. S., Malini, M., & Selvam, C. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13979 · Cited by 32

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

Zheng, J., Croteau, D. L., Bohr, V. A., & Akbari, M. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz083 · Cited by 32

AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes

Gélinas, R., Dontaine, J., Horman, S., Beauloye, C., Bultot, L., & Bertrand, L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00519 · Cited by 31

ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise

Coccimiglio, I. F., & Clarke, D. C. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008079 · Cited by 32

Fatty acid synthesis and cancer: Aberrant expression of the ACACA and ACACB genes increases the risk for cancer

Bhattacharjee, K., Nath, M., & Choudhury, Y. (2020) · Meta Gene · doi:10.1016/j.mgene.2020.100798 · Cited by 34

AMPK: Potential Therapeutic Target for Vascular Calcification

Lü, Y., Yuan, T., Min, X., Yuan, Z., & Cai, Z. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.670222 · Cited by 33

Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

Fung, T. S., Chakrabarti, R., Kollasser, J., Rottner, K., Stradal, T. E. B., Kage, F., & Higgs, H. N. (2022) · Current Biology · doi:10.1016/j.cub.2022.02.058 · Cited by 35

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis

Zhang, P., Fu, H.-J., Lv, L.-X., Liu, C.-F., Han, C. L., Zhao, X., & Wang, J. (2023) · Communications Biology · doi:10.1038/s42003-023-04735-z · Cited by 31

Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice

Yang, Y., Fang, H., Xie, Z., Ren, F., Yan, L., Zhang, M., Xu, G., Song, Z., Chen, Z., Sun, W., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01734-6 · Cited by 31

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C. L., Zagorodna, O., Dogruluk, T., Lu, H., Villafañe, N., Bhavana, V. H., Moreno, D., et al. (2020) · eLife · doi:10.7554/elife.48963 · Cited by 31

Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells

Zurli, V., Montecchi, T., Heilig, R., Poschke, I. C., Volkmar, M., Wimmer, G., Boncompagni, G., Turacchio, G., D’Elios, M. M., Campoccia, G., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aaz1965 · Cited by 34

Lactobacillus fermentum KP-3-fermented ginseng ameliorates alcohol-induced liver disease in C57BL/6N mice through the AMPK and MAPK pathways

You, Y., Liu, Y., Ai, Z., Wang, Y., Liu, J., Piao, C., & Wang, Y. (2020) · Food & Function · doi:10.1039/d0fo02396e · Cited by 30

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β

Goodman, C. A., Davey, J. R., Hagg, A., Parker, B. L., & Gregorevic, P. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100050 · Cited by 30

Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis*

Gómez, H., Rio‐Pertuz, G. D., Priyanka, P., Manrique-Caballero, C. L., Chang, C.-C. H., Wang, S., Liu, Q., Zuckerbraun, B. S., Murugan, R., Angus, D. C., et al. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005468 · Cited by 31

Physical loading in professional soccer players: Implications for contemporary guidelines to encompass carbohydrate periodization

Anderson, L. J., Drust, B., Close, G. L., & Morton, J. P. (2022) · Journal of Sports Sciences · doi:10.1080/02640414.2022.2044135 · Cited by 34

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

Flores, K., Siqués, P., Brito, J., & Arribas, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116205 · Cited by 30

SUMOylation of MFF coordinates fission complexes to promote stress-induced mitochondrial fragmentation

Seager, R., Ramesh, N. S., Cross, S., Guo, C., Wilkinson, K. A., & Henley, J. M. (2024) · Science Advances · doi:10.1126/sciadv.adq6223 · Cited by 32

Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges

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BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?

Wu, J., Ren, B., Shi, F., Hua, P., & Lin, H. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28710 · Cited by 29

Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective

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NUSAP1 promotes the metastasis of breast cancer cells via the AMPK/PPARγ signaling pathway

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DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

Narbonne, P., Maddox, P. S., & Labbé, J.-C. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006738 · Cited by 27

Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

Lockie, S. H., Stark, R., Méquinion, M., Ch’ng, S. S., Kong, D., Spanswick, D. C., Lawrence, A. J., & Andrews, Z. B. (2018) · Endocrinology · doi:10.1210/en.2018-00536 · Cited by 27

CARM1 Regulates AMPK Signaling in Skeletal Muscle

Stouth, D. W., vanLieshout, T. L., Ng, S. Y., Webb, E. K., Manta, A., Moll, Z., & Ljubicic, V. (2020) · iScience · doi:10.1016/j.isci.2020.101755 · Cited by 26

TFEB Signalling-Related MicroRNAs and Autophagy

Corà, D., Bussolino, F., & Doronzo, G. (2021) · Biomolecules · doi:10.3390/biom11070985 · Cited by 28

AMPK phosphorylates PPARδ to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth

Ding, J., Gou, Q., Jia, X., Liu, Q., Jin, J., Shi, J., & Hou, Y. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100954 · Cited by 28

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ovens, A. J., Gee, Y. S., Ling, N. X. Y., Yu, D., Hardee, J. P., Chung, J. D., Ngoei, K. R. W., Waters, N. J., Hoffman, N. J., Scott, J. W., et al. (2022) · Biochemical Journal · doi:10.1042/bcj20220067 · Cited by 27

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation

Centini, R. M., Tsang, M., Iwata, T., Park, H., Delrow, J. J., Margineantu, D. H., Iritani, B., Gu, H., Liggitt, H. D., Kang, J. S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197973 · Cited by 27

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

Ducommun, S., Deák, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, T. E., Viollet, B., Foretz, M., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.02.001 · Cited by 30

The emerging era of lactate: A rising star in cellular signaling and its regulatory mechanisms

Wu, D., Zhang, K., Khan, F. A., Wu, Q., Pandupuspitasari, N. S., Tang, Y. Y., Guan, K., Sun, F., & Huang, C. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30458 · Cited by 28

Effects of topical capsaicin combined with moderate exercise on insulin resistance, body weight and oxidative stress in hypoestrogenic obese rats

Contreras, J. M. D. L. M., Colado‐Velázquez, J. I., Gómez-Viquez, N. L., Mailloux‐Salinas, P., Pérez-Torres, I., Aranda‐Fraustro, A., Carvajal, K., & Bravo, G. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.33 · Cited by 27

Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition

Shen, Y., Sherman, J. W., Chen, X., & Wang, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001379 · Cited by 27

AMP-activated protein kinase controls lipid and lactose synthesis in bovine mammary epithelial cells

Huang, J., Guesthier, M.-A., & Burgos, S. A. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16343 · Cited by 28

PKA‐independent vasopressin signaling in renal collecting duct

Datta, A., Yang, C., Limbutara, K., Chou, C., Rinschen, M. M., Raghuram, V., & Knepper, M. A. (2020) · The FASEB Journal · doi:10.1096/fj.201902982r · Cited by 27

Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism

Pal, S., Porwal, K., Rajak, S., Sinha, R. A., & Chattopadhyay, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110207 · Cited by 27

DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

Yang, M., Luo, S., Jiang, N., Wang, X., Han, Y., Zhao, H., Xiong, X., Liu, Y., Zhao, C., Zhu, X., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659751 · Cited by 28

Irisin promotes the browning of white adipocytes tissue by AMPKα1 signaling pathway

Luo, X., Li, J., Zhang, H., Wang, Y., Shi, H., Ge, Y., Yu, X., Wang, H., & Dong, Y. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.08.025 · Cited by 25

From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies

Rey, V., & Tamargo‐Gómez, I. (2023) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases1030012 · Cited by 29

Control and Regulation of Substrate Selection in Cytoplasmic and Mitochondrial Catabolic Networks. A Systems Biology Analysis

Cortassa, S. C., Aon, M. A., & Sollott, S. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00201 · Cited by 27

Pyruvate kinase M2 contributes to cell growth in gastric cancer via aerobic glycolysis

Li, H., Xu, H., Xing, R., Pan, Y., Li, W., Cui, J., & Lu, Y. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.04.001 · Cited by 26

Intermediary metabolism: An intricate network at the crossroads of cell fate and function

Ferreira, L. M. R., Li, A. M., Serafim, T. L., Sobral, M. C. M., Alpoim, M. C., & Urbano, A. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165887 · Cited by 27

Energy Metabolism in Exercise-Induced Physiologic Cardiac Hypertrophy

Xiang, K., Qin, Z., Zhang, H., & Liu, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01133 · Cited by 26

The endocannabinoid system in the adipose organ

Jung, K., Lin, L., & Piomelli, D. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09623-z · Cited by 28

Treatment with ascorbic acid normalizes the aerobic capacity, antioxidant defence, and cell death pathways in thermally stressed Mytilus galloprovincialis

Feidantsis, K. G., Georgoulis, I., Giantsis, I. Α., & Michaelidis, B. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110611 · Cited by 26

Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Ondaro, J., Hernández-Eguiazu, H., Garciandia-Arcelus, M., Loera‐Valencia, R., Rodríguez-Gómez, L., Jiménez-Zúñiga, A., Goikolea, J., Rodriguez‐Rodriguez, P., Ruiz‐Martínez, J., Moreno, F., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.836196 · Cited by 28

Negative regulation of TGF-β by AMPK and implications in the treatment of associated disorders

Gao, J., Ye, J., Ying, Y., Lin, H., & Luo, Z. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy028 · Cited by 28

Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

Dunn, D. M., & Munger, J. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00384 · Cited by 27

E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATPPreprint

Ahel, J., Fletcher, A. J., Grabarczyk, D. B., Roitinger, E., Deszcz, L., Lehner, A., Virdee, S., & Clausen, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.10.443411 · Cited by 26

AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis

Laws, K. M., & Drummond‐Barbosa, D. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.006 · Cited by 25

The Exploration of Natural Compounds for Anti-Diabetes from Distinctive Species Garcinia linii with Comprehensive Review of the Garcinia Family

Chen, T., Tsai, M., Fu, Y., & Weng, C. (2019) · Biomolecules · doi:10.3390/biom9110641 · Cited by 25

Moderate hyperoxia induces inflammation, apoptosis and necrosis in human umbilical vein endothelial cells

Hafner, C. M., Wu, J., Soto-Gonzalez, L., Kaun, C., Stojković, S., Wojta, J., Tretter, V. E., Markstaller, K., & Klein, K. U. (2017) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000593 · Cited by 25

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

Zhang, R., Huang, S., Li, K. K., Li, Y.-H., Hsu, W.-H., Zhang, G., Chang, C.-J., & Yang, J.-Y. (2017) · Oncotarget · doi:10.18632/oncotarget.17769 · Cited by 25

Shexiang Baoxin Pill Corrects Metabolic Disorders in a Rat Model of Metabolic Syndrome by Targeting Mitochondria

Wei, D., Zheng, N., Zheng, L., Wang, L., Song, L., & Sun, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00137 · Cited by 25

Phosphoproteomic Analysis across the Yeast Life Cycle Reveals Control of Fatty Acyl Chain Length by Phosphorylation of the Fatty Acid Synthase Complex

Martínez-Montañés, F., Casanovas, A., Sprenger, R. R., Topolska, M., Marshall, D. L., Moreno‐Torres, M., Poad, B. L. J., Blanksby, S. J., Hermansson, M., Jensen, O. N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108024 · Cited by 23

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Nguyen, H. T., Wiederkehr, A., Wollheim, C. B., & Park, K. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01161-x · Cited by 24

Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases

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Striking Diversity in Holoenzyme Architecture and Extensive Conformational Variability in Biotin-Dependent Carboxylases

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