Cited by 397Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

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Caloric restriction, SIRT1 and longevity

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Cantó, Carles, Auwerx, Johan·2009·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2009.03.008PMC PMC3627124

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Abstract

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of its ability to integrate sensing of the metabolic status with adaptive transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis.

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Authors: Cantó, C., & Auwerx, J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Auwerx, Johan
ORCID: Cantó, Carles
Auwerx, Johan
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2009-09
Volume: 20
Issue: 7
Pages: 325-331
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2009.03.008
PMC: PMC3627124
OpenAlex: W2090225971
Cited by: 395
References: 111
Citations by year: 2026: 9 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 12 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 30 · 2017: 18 · 2016: 23 · 2015: 33 · 2014: 24 · 2013: 28 · 2012: 27
FWCI: 3.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: caloric restriction, SIRT1, Sir2, longevity, lifespan extension, metabolic disorders, metabolic sensing, transcriptional regulation, non-pharmacological treatment
MeSH terms: Adaptation, Physiological, Animals, Humans, Longevity, Caloric Restriction, Sirtuins, Sirtuin 1

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Caloric restriction, SIRT1 and longevity

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