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Caloric restriction, SIRT1 and longevity
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More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of its ability to integrate sensing of the metabolic status with adaptive transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis.
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“The levels of SIRT-1 are higher in the muscular tissue in the presence of caloric restriction (calorie intake lower of about 20–40%) [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]
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“The direct activation of SIRT-1 by resveratrol is controversial since in-vitro experiments have shown that the interaction between resveratrol and the artificial fluorescent substrate used could generate artifacts [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]
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Metadata
- Authors
- Cantó, C., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 20
- Issue
- 7
- Pages
- 325-331
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3627124
- OpenAlex
- W2090225971
- Cited by
- 395
- References
- 111
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 12 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 30 · 2017: 18 · 2016: 23 · 2015: 33 · 2014: 24 · 2013: 28 · 2012: 27
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- caloric restriction, SIRT1, Sir2, longevity, lifespan extension, metabolic disorders, metabolic sensing, transcriptional regulation, non-pharmacological treatment
- MeSH terms
- Adaptation, Physiological, Animals, Humans, Longevity, Caloric Restriction, Sirtuins, Sirtuin 1
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