The DOI matches its Crossref record; 110 of the 111 references it cites were found in a registry or an index.
Caloric restriction, SIRT1 and longevity
Open accessAbstract
More than 70 years after its initial report, caloric restriction stands strong as the most consistent non-pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of its ability to integrate sensing of the metabolic status with adaptive transcriptional outputs. This review focuses on gathered evidence suggesting that Sir2/SIRT1 is a key mediator of the beneficial effects of caloric restriction and addresses the main questions that still need to be answered to consolidate this hypothesis.
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“The levels of SIRT-1 are higher in the muscular tissue in the presence of caloric restriction (calorie intake lower of about 20–40%) [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]
In the citing paper
“The direct activation of SIRT-1 by resveratrol is controversial since in-vitro experiments have shown that the interaction between resveratrol and the artificial fluorescent substrate used could generate artifacts [15].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [15]
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Cites
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
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Self-citationSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Self-citationNutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
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“The recombination at this locus is repressed by the yeast SIR2 gene [20].”
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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Research works printed but not linked: 1
- Verdery, 1997, Caloric restriction increases HDL2 levels in rhesus monkeys (Macacamulatta), Am. J. Physiol., 273, E714
Cited by
Sorted by citations
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Self-citationTimmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320
Self-citationPhysiological and pathological cardiac hypertrophy
Shimizu, I., & Minamino, T. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.06.001 · Cited by 919
AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Luen Tang, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2318 · Cited by 740
Metadata
- Authors
- Cantó, C., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 20
- Issue
- 7
- Pages
- 325-331
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3627124
- OpenAlex
- W2090225971
- Cited by
- 395
- References
- 111
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 12 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 30 · 2017: 18 · 2016: 23 · 2015: 33 · 2014: 24 · 2013: 28 · 2012: 27
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- caloric restriction, SIRT1, Sir2, longevity, lifespan extension, metabolic disorders, metabolic sensing, transcriptional regulation, non-pharmacological treatment
- MeSH terms
- Adaptation, Physiological, Animals, Humans, Longevity, Caloric Restriction, Sirtuins, Sirtuin 1
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