Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining
Abstract
Skeletal muscle primarily relies on carbohydrate (CHO) for energy provision during high-intensity exercise. We hypothesized that sprint interval training (SIT), or repeated sessions of high-intensity exercise, would induce rapid changes in transport proteins associated with CHO metabolism, whereas changes in skeletal muscle fatty acid transporters would occur more slowly. Eight active men (22 ± 1 yr; peak oxygen uptake = 50 ± 2 ml·kg−1·min−1) performed 4–6 × 30 s all-out cycling efforts with 4-min recovery, 3 days/wk for 6 wk. Needle muscle biopsy samples (vastus lateralis) were obtained before training (Pre), after 1 and 6 wk of SIT, and after 1 and 6 wk of detraining. Muscle oxidative capacity, as reflected by the protein content of cytochrome c oxidase subunit 4 (COX4), increased by ∼35% after 1 wk of SIT and remained higher compared with Pre, even after 6 wk of detraining ( P < 0.05). Muscle GLUT4 content increased after 1 wk of SIT and remained ∼20% higher compared with baseline during detraining ( P < 0.05). The monocarboxylate tranporter (MCT) 4 was higher after 1 and 6 wk of SIT compared with Pre, whereas MCT1 increased after 6 wk of training and remained higher after 1 wk of detraining ( P < 0.05). There was no effect of training or detraining on the muscle content of fatty acid translocase (FAT/CD36) or plasma membrane associated fatty acid binding protein (FABPpm) ( P > 0.05). We conclude that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate, and fatty acid transport.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During exercise, glycolytic flux in the skeletal muscles can be dramatically increased.
“During exercise, glycolytic flux in the skeletal muscles can be dramatically increased [127,128].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [128]
This study extends previous literature showing beneficial effects of high-intensity interval training by showing that sprint number and duration can be substantially reduced whilst still maintaining positive effects.
“This study extends the previous literature showing the beneficial effects of HIT (Burgomaster et al. 2007;Babraj et al. 2009;Richards et al. 2010;Whyte et al. 2010;Rakobowchuk et al. 2008;Trilk et al. 2010) by showing that the sprint number and duration can be substantially reduced whilst still maintaining positive effects.”
From Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training (2012) · cites this paper as Burgomaster et al. 2007
Cites
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., Raha, S., & Tarnopolsky, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112094 · Cited by 1,082 · see citing works
Self-citationThe effects of increasing exercise intensity on muscle fuel utilisation in humans
van Loon, L. J. C., Greenhaff, P. L., Constantin‐Teodosiu, D., Saris, W. H. M., & Wagenmakers, A. J. M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00295.x · Cited by 897 · see citing works
Burgomaster, K. A., Hughes, S. C., Heigenhauser, G. J. F., Bradwel, S. N., & Gibala, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01095.2004 · Cited by 856 · see citing works
Self-citationEffect of training on enzyme activity and fiber composition of human skeletal muscle.
Gollnick, P. D., Armstrong, R. B., Saltin, B., Saubert, C. W., Sembrowich, W. L., & Shepherd, R. E. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.34.1.107 · Cited by 637 · see citing works
Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F. (2004) · Diabetes · doi:10.2337/diabetes.53.2.294 · Cited by 615 · see citing works
Burgomaster, K. A., Heigenhauser, G. J. F., & Gibala, M. J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01220.2005 · Cited by 432 · see citing works
Self-citationBonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410 · see citing works
Self-citationTime course of loss of adaptations after stopping prolonged intense endurance training
Coyle, E. F., Martin, W. H., Sinacore, D. R., Joyner, M. J., Hagberg, J. M., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.6.1857 · Cited by 364 · see citing works
Intracellular signaling specificity in skeletal muscle in response to different modes of exercise
Nader, G. A., & Esser, K. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1936 · Cited by 363 · see citing works
Optimizing fat oxidation through exercise and diet
Achten, J., & Jeukendrup, A. E. (2004) · Nutrition · doi:10.1016/j.nut.2004.04.005 · Cited by 361 · see citing works
Henriksson, J., & Reitman, J. S. (1977) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1977.tb10356.x · Cited by 345 · see citing works
Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise
Parolin, M. L., Chesley, A., Matsos, M. P., Spriet, L. L., Jones, N. L., & Heigenhauser, G. J. F. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e890 · Cited by 334 · see citing works
Exercise training increases lipid metabolism gene expression in human skeletal muscle
Tunstall, R. J., Mehan, K. A., Wadley, G. D., Collier, G. R., Bonen, A., Hargreaves, M., & Cameron-Smith, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2001 · Cited by 292 · see citing works
Self-citationDiPietro, L., Dziura, J., Yeckel, C. W., & Neufer, P. D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00474.2005 · Cited by 270 · see citing works
Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle
Juel, C., Klarskov, C., Nielsen, J., Krustrup, P., Mohr, M., & Bangsbo, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00303.2003 · Cited by 243 · see citing works
Muscle power and metabolism in maximal intermittent exercise.
McCartney, N., Spriet, L. L., Heigenhauser, G. J., Kowalchuk, J. M., Sutton, J. R., & Jones, N. L. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.4.1164 · Cited by 242 · see citing works
A short training programme for the rapid improvement of both aerobic and anaerobic metabolism
Rodas, G., Ventura, J. L., Cadefau, J. A., Cussó, R., & Parra, J. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000223 · Cited by 235 · see citing works
Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle
Pilegaard, H., Domino, K., Noland, T. D., Juel, C., Hellsten, Y., Halestrap, A. P., & Bangsbo, J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.2.e255 · Cited by 219 · see citing works
Wibom, R., Hultman, E., Johansson, M., Matherei, K., Constantin-Teodosiu, D., & Schantz, P. G. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.2004 · Cited by 208 · see citing works
Thomas, C., Perrey, S., Lambert, K., Hugon, G., Mornet, D., & Mercier, J. G. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01057.2004 · Cited by 167 · see citing works
Skeletal muscle adaptation in adolescent boys
Fournier, M., Ricci, J., Taylor, A. W., FERGUSON, R. J., Montpetit, R. R., & CHAITMAN, B. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198206000-00008 · Cited by 155 · see citing works
Kiens, B., Kristiansen, S., Jensen, P. B., Richter, E. A., & Turcotte, L. P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6118 · Cited by 143 · see citing works
PARRA, J., Cadefau, J. A., Rodas, G., Amigó, N., & Cussó, R. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00730.x · Cited by 141 · see citing works
Bonen, A., McCullagh, K. J. A., Putman, C. T., Hultman, E., Jones, N. L., & Heigenhauser, G. J. F. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e102 · Cited by 141 · see citing works
Self-citationFat Metabolism in Heavy Exercise
Jones, N. L., Heigenhauser, G. J. F., Kuksis, A., Matsos, C. G., Sutton, J. R., & Toews, C. J. (1980) · Clinical Science · doi:10.1042/cs0590469 · Cited by 136 · see citing works
Terada, S., Yokozeki, T., Kawanaka, K., Ogawa, K., Higuchi, M., Ezaki, O., & Tabata, I. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2019 · Cited by 134 · see citing works
Baker, S. K., McCullagh, K. J. A., & Bonen, A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.3.987 · Cited by 131 · see citing works
Self-citationChanges in insulin action and GLUT-4 with 6 days of inactivity in endurance runners
Vukovich, M. D., Arciero, P. J., Kohrt, W. M., Racette, S. B., Hansen, P. A., & Holloszy, J. O. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.1.240 · Cited by 110 · see citing works
Skeletal muscle pyruvate dehydrogenase activity during maximal exercise in humans
Putman, C. T., Jones, N. L., Lands, L. C., Bragg, T. M., Hollidge-Horvat, M. G., & Heigenhauser, G. J. F. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.3.e458 · Cited by 110 · see citing works
Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles
Bonen, A., Miskovic, D., Tonouchi, M., Lemieux, K., Wilson, M. C., Marette, A., & Halestrap, A. P. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e1067 · Cited by 106 · see citing works
Self-citationEffects of high‐intensity intermittent swimming on PGC‐1α protein expression in rat skeletal muscle
Terada, S., Kawanaka, K., Goto, M., Shimokawa, T., & Tabata, I. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01423.x · Cited by 93 · see citing works
Tabata, I., Suzuki, Y., Fukunaga, T., Yokozeki, T., Akima, H., & Funato, K. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.909 · Cited by 92 · see citing works
Greiwe, J. S., Holloszy, J. O., & Semenkovich, C. F. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.176 · Cited by 91 · see citing works
The effects of short-term sprint training on MCT expression in moderately endurance-trained runners
Bickham, D. C., Bentley, D. J., Rossignol, P., & Cameron‐Smith, D. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0100-x · Cited by 87 · see citing works
Seven days of exercise increase GLUT-4 protein content in human skeletal muscle
Houmard, J. A., Hickey, M. S., Tyndall, G. L., Gavigan, K. E., & Dohm, G. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.6.1936 · Cited by 82 · see citing works
Increments in skeletal muscle GLUT-1 and GLUT-4 after endurance training in humans
Phillips, S. M., Han, X. X., Green, H. J., & Bonen, A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e456 · Cited by 78 · see citing works
Self-citationEnzyme adaptations of human skeletal muscle during bicycle short‐sprint training and detraining
Linossier, M., Dormois, D., PERIER, C., FREY, J., GEYSSANT, A., & Denis, C. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00244.x · Cited by 77 · see citing works
Effect of 7-10 days of cycle ergometer exercise on skeletal muscle GLUT-4 protein content
Gulve, E. A., & Spina, R. J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.5.1562 · Cited by 77 · see citing works
Sensitized Ho3+ up-conversion luminescence in Nd3+–Yb3+–Ho3+ co-doped ZrF4-based glass
Qiu, J., Shojiya, M., & Kawamoto, Y. (1999) · Journal of Applied Physics · doi:10.1063/1.370822 · Cited by 75 · see citing works
Simoneau, J. A., Lortie, G., Boulay, M. R., Marcotte, M., Thibault, M. C., & Bouchard, C. (1987) · European Journal of Applied Physiology · doi:10.1007/bf00635363 · Cited by 75 · see citing works
Effect of detraining on GLUT-4 protein in human skeletal muscle
McCoy, M., Proietto, J., & Hargreves, M. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.3.1532 · Cited by 61 · see citing works
Training cessation does not alter GLUT-4 protein levels in human skeletal muscle
Houmard, J. A., Hortobágyi, T., Neufer, P. D., Johns, R. A., Fraser, D. D., Israel, R. G., & Dohm, G. L. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.2.776 · Cited by 51 · see citing works
Electrical relaxation mechanism in unconventional bismuth cuprate glasses
Hazra, S., & Ghosh, A. (1998) · Journal of Applied Physics · doi:10.1063/1.368165 · Cited by 50 · see citing works
Training-induced changes in membrane transport proteins of human skeletal muscle
Juel, C. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0140-x · Cited by 46 · see citing works
Effect of reduced training and training cessation on insulin action and muscle GLUT-4
Houmard, J. A., Tyndall, G. L., Midyette, J. B., Hickey, M. S., Dolan, P. L., Gavigan, K. E., Weidner, M. L., & Dohm, G. L. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.3.1162 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257 · see citing works
Self-citationRepeated-Sprint Ability – Part I: Factors Contributing to Fatigue
Girard, O., Mendez-Villanueva, A., & Bishop, D. (2011) · Sports Medicine · doi:10.2165/11590550-000000000-00000 · Cited by 916 · see citing works
Batacan, R. B., Duncan, M. J., Dalbo, V. J., Tucker, P. S., & Fenning, A. S. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095841 · Cited by 799 · see citing works
Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 755 · see citing works
Self-citationGibala, M. J., & McGee, S. L. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e318168ec1f · Cited by 682 · see citing works
Self-citationLittle, J. P., Safdar, A., Wilkin, G. P., Tarnopolsky, M. A., & Gibala, M. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181743 · Cited by 672 · see citing works
Self-citationRepeated-Sprint Ability – Part II: Recommendations for Training
Bishop, D., Girard, O., & Mendez-Villanueva, A. (2011) · Sports Medicine · doi:10.2165/11590560-000000000-00000 · Cited by 621 · see citing works
Bartlett, J. D., Close, G. L., MacLaren, D. P. M., Gregson, W., Drust, B., & Morton, J. P. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2010.545427 · Cited by 593 · see citing works
Gillen, J. B., & Gibala, M. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0187 · Cited by 506 · see citing works
Self-citationWhyte, L. J., Gill, J. M. R., & Cathcart, A. J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.002 · Cited by 424 · see citing works
Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults
HOOD, M. S., LITTLE, J. P., TARNOPOLSKY, M. A., MYSLIK, F., & GIBALA, M. J. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182199834 · Cited by 375 · see citing works
Self-citationBabraj, J. A., Vollaard, N. B., Keast, C., Guppy, F. M., Cottrell, G., & Timmons, J. A. (2009) · BMC Endocrine Disorders · doi:10.1186/1472-6823-9-3 · Cited by 374 · see citing works
Effects of Physical Activity and Inactivity on Muscle Fatigue
Bogdanis, G. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00142 · Cited by 356 · see citing works
Rakobowchuk, M., Tanguay, S., Burgomaster, K. A., Howarth, K. R., Gibala, M. J., & MacDonald, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00069.2008 · Cited by 335 · see citing works
Self-citationSprint Interval Training Effects on Aerobic Capacity: A Systematic Review and Meta-Analysis
Gist, N. H., Fedewa, M. V., Dishman, R. K., & Cureton, K. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0115-0 · Cited by 332 · see citing works
Perry, C. G. R., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-097 · Cited by 309 · see citing works
Self-citationSloth, M., Sloth, D., Overgaard, K., & Dalgas, U. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12092 · Cited by 314 · see citing works
Metcalfe, R. S., Babraj, J. A., Fawkner, S. G., & Vollaard, N. B. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2254-z · Cited by 294 · see citing works
Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019) · Sports Medicine · doi:10.1007/s40279-019-01167-w · Cited by 286 · see citing works
Run Sprint Interval Training Improves Aerobic Performance but Not Maximal Cardiac Output
MacPherson, R. E. K., Hazell, T. J., Olver, T. D., Paterson, D. H., & Lemon, P. W. R. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e5eacd · Cited by 274 · see citing works
10 or 30-S Sprint Interval Training Bouts Enhance Both Aerobic and Anaerobic Performance
Hazell, T. J., MacPherson, R. E. K., Gravelle, B. M. R., & Lemon, P. W. R. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1474-y · Cited by 272 · see citing works
ATAKAN, M. M., Li, Y., Koşar, Ş. N., Turnagöl, H. H., & Yan, X. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18137201 · Cited by 291 · see citing works
Role of intramyocelluar lipids in human health
Coen, P. M., & Goodpaster, B. H. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.05.009 · Cited by 252 · see citing works
A Critical Evaluation of Current Methods for Exercise Prescription in Women and Men
Iannetta, D., Inglis, E. C., Mattu, A. T., Fontana, F. Y., Pogliaghi, S., Keir, D. A., & Murias, J. M. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002147 · Cited by 243 · see citing works
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 221 · see citing works
Shepherd, S. O., Cocks, M., Tipton, K. D., Ranasinghe, A. M., Barker, T. A., Burniston, J. G., Wagenmakers, A. J. M., & Shaw, C. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240952 · Cited by 207 · see citing works
McRae, G., Payne, A., Zelt, J. G. E., Scribbans, T. D., Jung, M. E., Little, J. P., & Gurd, B. J. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-093 · Cited by 206 · see citing works
Bartlett, J. D., Joo, C.-H., Jeong, T.-S., Louhelainen, J., Cochran, A. J. R., Gibala, M. J., Gregson, W. A., Close, G. L., Drust, B., & Morton, J. P. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01040.2011 · Cited by 200 · see citing works
Self-citationBogdanis, G. C., Stavrinou, P. S., Fatouros, I. G., Philippou, Α., Chatzinikolaou, A., Draganidis, D., Ermιdis, G., & Maridaki, M. D. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.046 · Cited by 196 · see citing works
De Nardi, A. T., Tolves, T., Lenzi, T. L., Signori, L. U., & Silva, A. M. V. D. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.12.017 · Cited by 191 · see citing works
Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
Evans, P. L., McMillin, S. L., Weyrauch, L. A., & Witczak, C. A. (2019) · Nutrients · doi:10.3390/nu11102432 · Cited by 190 · see citing works
Endurance Training and Obesity
Venables, M., & Jeukendrup, A. E. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815f256f · Cited by 189 · see citing works
Richards, J. C., Johnson, T. K., Kuzma, J. N., Lonac, M. C., Schweder, M. M., Voyles, W. F., & Bell, C. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.189886 · Cited by 187 · see citing works
Iaia, F. M., & Bangsbo, J. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2010.01193.x · Cited by 182 · see citing works
Mitochondrial Lactate Oxidation Complex and an Adaptive Role for Lactate Production
Hashimoto, T., & Brooks, G. A. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815fcb04 · Cited by 174 · see citing works
The impact of brief high-intensity exercise on blood glucose levels
Adams, P. J. (2013) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s29222 · Cited by 173 · see citing works
Talanian, J. L., Holloway, G. P., Snook, L. A., Heigenhauser, G. J. F., Bonen, A., & Spriet, L. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2010 · Cited by 167 · see citing works
Self-citationDeighton, K., Barry, R., Connon, C. E., & Stensel, D. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2535-1 · Cited by 165 · see citing works
McKay, B. R., Paterson, D. H., & Kowalchuk, J. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90828.2008 · Cited by 164 · see citing works
Contextualising Maximal Fat Oxidation During Exercise: Determinants and Normative Values
Maunder, E., Plews, D. J., & Kilding, A. E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00599 · Cited by 163 · see citing works
A Genome Scan for Positive Selection in Thoroughbred Horses
Gu, J., Orr, N., Park, S. D., Katz, L. M., Сулимова, Г. Е., MacHugh, D. E., & Hill, E. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005767 · Cited by 157 · see citing works
Trilk, J. L., Singhal, A., Bigelman, K. A., & Cureton, K. J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1777-z · Cited by 130 · see citing works
Performance in sports – With specific emphasis on the effect of intensified training
Bangsbo, J. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12605 · Cited by 143 · see citing works
Cochran, A. J. R., Percival, M. E., Tricarico, S., Little, J. P., Cermak, N. M., Gillen, J. B., Tarnopolsky, M. A., & Gibala, M. J. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2013.077453 · Cited by 122 · see citing works
Self-citationLarsen, S., Danielsen, J., Søndergård, S. D., Søgaard, D., Vigelsø, A., Dybboe, R., Skaaby, S., Dela, F., & Helge, J. W. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12252 · Cited by 124 · see citing works
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview
Holloway, G. P., Luiken, J. J. F. P., Glatz, J. F. C., Spriet, L. L., & Bonen, A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01878.x · Cited by 120 · see citing works
Self-citationThomassen, M., Christensen, P. M., Gunnarsson, T. P., Nybo, L., & Bangsbo, J. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01015.2009 · Cited by 115 · see citing works
Iaia, F. M., Thomassen, M., Kolding, H., Gunnarsson, T. P., Wendell, J., Rostgaard, T., Nordsborg, N. B., Krustrup, P., Nybo, L., Hellsten, Y., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00666.2007 · Cited by 115 · see citing works
Effects of high-intensity interval training on pulmonary function
Dunham, C. B., & Harms, C. A. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2285-5 · Cited by 113 · see citing works
Bangsbo, J., Gunnarsson, T. P., Wendell, J., Nybo, L., & Thomassen, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00358.2009 · Cited by 111 · see citing works
Thomas, C., Bishop, D. J., Lambert, K., Mercier, J. G., & Brooks, G. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00250.2011 · Cited by 110 · see citing works
Sprint Interval Training in Hypoxia Stimulates Glycolytic Enzyme Activity
Puype, J., Proeyen, K. V., Raymackers, J., Deldicque, L., & Hespel, P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31829734ae · Cited by 111 · see citing works
Regulation of Energy Substrate Metabolism in Endurance Exercise
Alghannam, A. F., Ghaith, M. M., & Alhussain, M. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094963 · Cited by 104 · see citing works
The SLC16 monocaboxylate transporter family
Meredith, D., & Christian, H. (2008) · Xenobiotica · doi:10.1080/00498250802010868 · Cited by 103 · see citing works
Flores-Opazo, M., McGee, S. L., & Hargreaves, M. (2020) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000224 · Cited by 102 · see citing works
Hostrup, M., & Bangsbo, J. (2016) · The Journal of Physiology · doi:10.1113/jp273218 · Cited by 100 · see citing works
Phillips, B. E., Kelly, B. M., Lilja, M. R., Ponce‐González, J. G., Brogan, R. J., Morris, D. L., Gustafsson, T. P., Kraus, W. E., Atherton, P. J., Vollaard, N. B. J., et al. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00229 · Cited by 98 · see citing works
Benton, C. R., Yoshida, Y., Lally, J., Han, X.-X., Hatta, H., & Bonen, A. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90217.2008 · Cited by 97 · see citing works
Self-citationCerebral metabolism after forced or voluntary physical exercise
Kinni, H. A., Guo, M., Ding, J. Y., Konakondla, S., Dornbos, D., Tran, R., Guthikonda, M., & Ding, Y. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.076 · Cited by 91 · see citing works
Bishop, D. J., Edge, J., Thomas, C., & Mercier, J. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00863.2007 · Cited by 97 · see citing works
Rakobowchuk, M., Stuckey, M. I., Millar, P. J., Gurr, L. J., & MacDonald, M. J. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0964-7 · Cited by 87 · see citing works
Running sprint interval training induces fat loss in women
Hazell, T. J., Hamilton, C. D., Olver, T. D., & Lemon, P. W. R. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0503 · Cited by 86 · see citing works
HIIT is superior than MICT on cardiometabolic health during training and detraining
Gripp, F., Nava, R. C., Cassilhas, R. C., Esteves, E. A., Magalhães, C. O. D. E., Dias‐Peixoto, M. F., Magalhães, F. D. C., & Amorim, F. T. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04502-6 · Cited by 81 · see citing works
The Effect of Two Speed Endurance Training Regimes on Performance of Soccer Players
Iaia, F. M., Fiorenza, M., Perri, E., Alberti, G., Millet, G. P., & Bangsbo, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138096 · Cited by 83 · see citing works
Fransson, D., Nielsen, T. S., Olsson, K., Christensson, T., Bradley, P. S., Fatouros, I. G., Krustrup, P., Nordsborg, N. B., & Mohr, M. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3751-5 · Cited by 82 · see citing works
MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study
Cupeiro, R., Benito, P. J., Maffulli, N., Calderón, F. J., & González‐Lamuño, D. (2009) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2009.07.004 · Cited by 79 · see citing works
Mitchell, E. A., Martin, N. R. W., Turner, M. C., Taylor, C. W., & Ferguson, R. A. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01082.2017 · Cited by 77 · see citing works
The 10-20-30 training concept improves performance and health profile in moderately trained runners
Gunnarsson, T. P., & Bangsbo, J. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00334.2012 · Cited by 77 · see citing works
Tucker, W. J., Angadi, S. S., & Gaesser, G. A. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001399 · Cited by 76 · see citing works
Changes in fat oxidation in response to various regimes of high intensity interval training (HIIT)
Astorino, T. A., & Schubert, M. M. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3756-0 · Cited by 74 · see citing works
Battaglia, G. M., Zheng, D., Hickner, R. C., & Houmard, J. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2012 · Cited by 74 · see citing works
Skeletal muscle disorders of glycogenolysis and glycolysis
Godfrey, R., & Quinlivan, R. C. M. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.75 · Cited by 73 · see citing works
Brocherie, F., Millet, G. P., D’Hulst, G., Thienen, R. V., Deldicque, L., & Girard, O. (2017) · Acta Physiologica · doi:10.1111/apha.12851 · Cited by 71 · see citing works
Vincent, G. E., Lamon, S., Gant, N., Vincent, P. J., MacDonald, J. R., Markworth, J. F., Edge, J., & Hickey, A. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00051 · Cited by 70 · see citing works
Stepto, N., Benziane, B., Wadley, G., Chibalin, A., Canny, B., Eynon, N., & McConell, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053080 · Cited by 68 · see citing works
Wylie, L. J., Ortiz de Zevallos, J., Isidore, T., Nyman, L., Vanhatalo, A., Bailey, S. J., & Jones, A. M. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.04.004 · Cited by 67 · see citing works
Miller, M. B., Pearcey, G. E. P., Cahill, F., McCarthy, H., Stratton, S. B. D., Noftall, J. C., Buckle, S., Basset, F. A., Sun, G., & Button, D. C. (2014) · BioMed Research International · doi:10.1155/2014/191797 · Cited by 68 · see citing works
de Mello, M. B., Righi, N. C., Schuch, F. B., Signori, L. U., & da Silva, A. M. V. (2022) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2021.101586 · Cited by 63 · see citing works
Skleryk, J. R., Karagounis, L. G., Hawley, J. A., Sharman, M. J., Laursen, P. B., & Watson, G. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12150 · Cited by 63 · see citing works
Autonomic recovery following sprint interval exercise
Stuckey, M. I., Tordi, N., Mourot, L., Gurr, L. J., Rakobowchuk, M., Millar, P. J., Tóth, R., MacDonald, M. J., & Kamath, M. V. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01320.x · Cited by 63 · see citing works
Forbes, S. C., Slade, J. M., & Meyer, R. A. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-099 · Cited by 59 · see citing works
Thurlow, F., Huynh, M., TOWNSHEND, A. D., McLaren, S. J., James, L. P., Taylor, J. M., Weston, M., & Weakley, J. J. S. (2023) · Sports Medicine · doi:10.1007/s40279-023-01959-1 · Cited by 58 · see citing works
Inspiratory muscle training reduces blood lactate concentration during volitional hyperpnoea
Brown, P. I., Sharpe, G. R., & Johnson, M. A. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0794-7 · Cited by 56 · see citing works
Kitaoka, Y., Masuda, H., Mukai, K., Hiraga, A., Takemasa, T., & Hatta, H. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.055483 · Cited by 54 · see citing works
Thomas, C., Bishop, D. J., Edge, J., & Mercier, J. G. (2008) · HAL · Cited by 56 · see citing works
Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism
Lund, J., Aas, V., Tingstad, R. H., Hees, A. V., & Nikolić, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-28249-5 · Cited by 53 · see citing works
Effects of Low-Volume, High-Intensity Whole-Body Calisthenics on Army ROTC Cadets
Gist, N. H., Freese, E. C., RYAN, T. E., & Cureton, K. J. (2015) · Military Medicine · doi:10.7205/milmed-d-14-00277 · Cited by 53 · see citing works
McGinley, C., & Bishop, D. J. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00630.2016 · Cited by 51 · see citing works
K. Ma, J., D. Scribbans, T., A. Edgett, B., Colin Boyd, J., A. Simpson, C., P. Little, J., & J. Gurd, B. (2013) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2013.34027 · Cited by 47 · see citing works
Mavropalias, G., Sim, M., Taaffe, D. R., Galvao, D. A., Spry, N. A., Kraemer, W. J., Häkkinen, K., & Newton, R. U. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-03927-0 · Cited by 48 · see citing works
An acute bout of endurance exercise but not sprint interval exercise enhances insulin sensitivity
Brestoff, J. R., Clippinger, B. B., Spinella, T., von DUVILLARD, S. P., Nindl, B. C., & Arciero, P. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-126 · Cited by 46 · see citing works
Hoshino, D., Yoshida, Y., Kitaoka, Y., Hatta, H., & Bonen, A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0257 · Cited by 47 · see citing works
Self-citationThe effects of short-term detraining on exercise performance in soccer players
Joo, C.-H. (2016) · Journal of Exercise Rehabilitation · doi:10.12965/jer.160280 · Cited by 45 · see citing works
Oxidative stress and metabolism meet epigenetic modulation in physical exercise
García‐Giménez, J. L., Cánovas‐Cervera, I., & Pallardó, F. V. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.008 · Cited by 49 · see citing works
Extremely short duration sprint interval training improves vascular health in older adults
Adamson, S., Kavaliauskas, M., Yamagishi, T., Phillips, S., Lorimer, R., & Babraj, J. (2018) · Sport Sciences for Health · doi:10.1007/s11332-018-0498-2 · Cited by 44 · see citing works
Self-citationEskelinen, J., HEINONEN, I. H. A., Löyttyniemi, E., Saunavaara, V., Kirjavainen, A. K., Virtanen, K. A., Hannukainen, J. C., & Kalliokoski, K. K. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01122.2014 · Cited by 43 · see citing works
Bradley, H., Shaw, C. S., Worthington, P. L., Shepherd, S. O., Cocks, M. S., & Wagenmakers, A. J. M. (2014) · Physiological Reports · doi:10.14814/phy2.12085 · Cited by 41 · see citing works
High Intensity Training Improves Health and Physical Function in Middle Aged Adults
Adamson, S., Lorimer, R., Cobley, J. N., Lloyd, R., & Babraj, J. (2014) · Biology · doi:10.3390/biology3020333 · Cited by 41 · see citing works
Alvehus, M., Boman, N., Söderlund, K., Svensson, M., & Burén, J. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2879-9 · Cited by 39 · see citing works
Millar, P. J., Rakobowchuk, M., McCartney, N., & MacDonald, M. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-086 · Cited by 40 · see citing works
- Authors
- Burgomaster, K. A., Cermak, N. M., Phillips, S. M., Benton, C. R., Bonen, A., & Gibala, M. J.
- Affiliations
- McMaster University (CA)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2007-05
- Volume
- 292
- Issue
- 5
- Pages
- R1970-R1976
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2096392460
- Cited by
- 255
- References
- 45
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 10 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 17 · 2014: 13 · 2013: 28 · 2012: 15
- FWCI
- 49.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- sprint interval training, detraining, skeletal muscle, carbohydrate transport, glucose transport, GLUT4, MCT4, MCT1, lactate transport, fatty acid uptake, fatty acid translocase, cytochrome c oxidase, oxidative capacity, high-intensity exercise, vastus lateralis
- MeSH terms
- Carrier Proteins, Gene Expression Regulation, Humans, Male, Muscle Proteins, Time Factors, Exercise, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
