Dynamics of skeletal muscle lipid pools

Mechanisms for Insulin Resistance: Common Threads and Missing Links

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Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

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Mechanism of free fatty acid-induced insulin resistance in humans.

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Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

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Pathogenesis of type 2 diabetes mellitus

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Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

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FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

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Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

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Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities

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ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

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Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

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Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

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A Ceramide-Centric View of Insulin Resistance

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

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Hormone-sensitive Lipase Deficiency in Mice Causes Diglyceride Accumulation in Adipose Tissue, Muscle, and Testis

Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T. M., Wagner, E. F., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110355200 · Cited by 613 · see citing works

Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids

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Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

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PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

Yang, X., Lü, X., Lombès, M., Rha, G. B., Chi, Y., Guerin, T. M., Smart, E. J., & Liu, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.003 · Cited by 482 · see citing works

Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works

Mutations in CGI-58, the Gene Encoding a New Protein of the Esterase/Lipase/Thioesterase Subfamily, in Chanarin-Dorfman Syndrome

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The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy

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Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid–induced insulin resistance

Schenk, S., & Horowitz, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30566 · Cited by 407 · see citing works

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance

Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395 · see citing works

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356 · see citing works

OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 324 · see citing works

Dynamic Activity of Lipid Droplets: Protein Phosphorylation and GTP-Mediated Protein Translocation

Bartz, R., Zehmer, J. K., Zhu, M., Chen, Y., Serrero, G., Zhao, Y., & Liu, P. (2007) · Journal of Proteome Research · doi:10.1021/pr070158j · Cited by 316 · see citing works

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

Taschler, U., Radner, F. P. W., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Köfeler, H. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215434 · Cited by 284 · see citing works

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

Dubé, J. J., Amati, F., Toledo, F. G. S., Stefanović-Račić, M., Rossi, A. P., Coen, P. M., & Goodpaster, B. H. (2011) · Diabetologia · doi:10.1007/s00125-011-2065-0 · Cited by 272 · see citing works

Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle

Strączkowski, M., Kowalska, I., Nikołajuk, A., Dzienis-Straczkowska, S., Kinalska, I., Baranowski, M., Żendzian‐Piotrowska, M., Brzezinska, Z., & Górski, J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1215 · Cited by 258 · see citing works

LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues

Dalen, K. T., Dahl, T. B., Holter, E., Arntsen, B. M., Londos, C., Sztalryd, C., & Nebb, H. I. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.11.011 · Cited by 236 · see citing works

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

Kuramoto, K., Okamura, T., Yamaguchi, T., Nakamura, T. Y., Wakabayashi, S., Morinaga, H., Nomura, M., Yanase, T., Otsu, K., Usuda, N., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328708 · Cited by 236 · see citing works

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

Coen, P. M., Dubé, J. J., Amati, F., Stefanović-Račić, M., Ferrell, R. E., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes · doi:10.2337/db09-0988 · Cited by 229 · see citing works

Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

Eichmann, T. O., Kumari, M., Haas, J. T., Farese, R. V., Zimmermann, R., Lass, A., & Zechner, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400416 · Cited by 216 · see citing works

Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5

Shepherd, S. O., Cocks, M., Tipton, K. D., Ranasinghe, A. M., Barker, T. A., Burniston, J. G., Wagenmakers, A. J. M., & Shaw, C. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240952 · Cited by 207 · see citing works

Use of intramuscular triacylglycerol as a substrate source during exercise in humans

van Loon, L. J. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00368.2004 · Cited by 205 · see citing works

Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity

Moro, C., Bajpeyi, S., & Smith, S. R. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00624.2007 · Cited by 179 · see citing works

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

Bosma, M., Minnaard, R., Sparks, L. M., Schaart, G., Losen, M. H., Baets, M. H. D., Duimel, H., Kersten, S., Bickel, P. E., Schrauwen, P., et al. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0888-x · Cited by 168 · see citing works

Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase

Pagnon, J. C., Matzaris, M., Stark, R., Meex, R. C. R., Macaulay, S. L., Brown, W. A., O’Brien, P. E., Tiganis, T., & Watt, M. J. (2012) · Endocrinology · doi:10.1210/en.2012-1127 · Cited by 163 · see citing works

Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice

Harada, K., Shen, W., Patel, S., Natu, V. S., Wang, J., Osuga, J.-I., Ishibashi, S., & Kraemer, F. B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00259.2003 · Cited by 161 · see citing works

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

Schmitz‐Peiffer, C., & Biden, T. J. (2008) · Diabetes · doi:10.2337/db07-1769 · Cited by 160 · see citing works

Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans

Bergman, B. C., Hunerdosse, D. M., Kerege, A. A., Playdon, M. C., & Perreault, L. (2012) · Diabetologia · doi:10.1007/s00125-011-2419-7 · Cited by 159 · see citing works

Influence of Gender, Obesity, and Muscle Lipase Activity on Intramyocellular Lipids in Sedentary Individuals

Moro, C., Galgani, J. E., Luu, L. C. T., Pasarica, M., Mairal, A., Bajpeyi, S., Schmitz, G., Langin, D., Liebisch, G., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0053 · Cited by 149 · see citing works

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels

Bosma, M., Hesselink, M. K. C., Sparks, L. M., Timmers, S., Ferraz, M. J., Mattijssen, F., van Beurden, D., Schaart, G., de Baets, M. H., Verheyen, F. K., et al. (2012) · Diabetes · doi:10.2337/db11-1402 · Cited by 149 · see citing works

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

Huijsman, E., van de Par, C., Economou, C., van der Poel, C., Lynch, G. S., Schoiswohl, G., Haemmerle, G., Zechner, R., & Watt, M. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2009 · Cited by 145 · see citing works

Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction

Wang, H., Sreenivasan, U., Gong, D., O’Connell, K. A., Dabkowski, E. R., Hecker, P. A., Ionica, N., Кониг, М., Mahurkar, A., Sun, Y., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m032466 · Cited by 144 · see citing works

Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training

Alsted, T. J., Nybo, L., Schweiger, M., Fledelius, C., Jacobsen, P., Zimmermann, R., Zechner, R., & Kiens, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90912.2008 · Cited by 135 · see citing works

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

Bosma, M., Sparks, L. M., Hooiveld, G. J. E. J., Jörgensen, J. A., Houten, S. M., Schrauwen, P., Kersten, S., & Hesselink, M. K. C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.007 · Cited by 135 · see citing works

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

Skovbro, M., Baranowski, M., Skov-Jensen, C., Flint, A., Dela, F., Górski, J., & Helge, J. W. (2008) · Diabetologia · doi:10.1007/s00125-008-1014-z · Cited by 133 · see citing works

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

Badin, P.-M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D., & Moro, C. (2011) · Diabetes · doi:10.2337/db10-1364 · Cited by 132 · see citing works

Hormone-sensitive Lipase Null Mice Exhibit Signs of Impaired Insulin Sensitivity whereas Insulin Secretion Is Intact

Mulder, H., Sörhede‐Winzell, M., Contreras, J. A., Fex, M., Ström, K., Ploug, T., Galbo, H., Arner, P., Lundberg, C., Sundler, F., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213032200 · Cited by 125 · see citing works

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

Pollak, N. M., Schweiger, M., Jaeger, D., Kolb, D., Kumari, M., Schreiber, R., Kolleritsch, S., Markolin, P., Grabner, G. F., Heier, C., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034710 · Cited by 123 · see citing works

Increased Hepatic Insulin Sensitivity Together with Decreased Hepatic Triglyceride Stores in Hormone-Sensitive Lipase-Deficient Mice

Voshol, P. J., Haemmerle, G., Ouwens, D. M., Zimmermann, R., Zechner, R., Teusink, B., Maassen, J. A., Havekes, L. M., & Romijn, J. A. (2003) · Endocrinology · doi:10.1210/en.2002-0036 · Cited by 119 · see citing works

Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet–Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation

Hoy, A. J., Bruce, C. R., Turpin-Nolan, S. M., Morris, A. J., Febbraio, M. A., & Watt, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0661 · Cited by 116 · see citing works

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat

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Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice

Chen, W., Chang, B. H.-J., Wu, X., Li, L., Sleeman, M. W., & Chan, L. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00523.2012 · Cited by 111 · see citing works

Kinetics of intramuscular triglyceride fatty acids in exercising humans

Guo, Z., Burguera, B., & Jensen, M. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2057 · Cited by 110 · see citing works

G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase

Schweiger, M., Paar, M., Eder, C., Brandis, J., Moser, E., Gorkiewicz, G., Grond, S., Radner, F. P. W., Cerk, I. K., Cornaciu, I., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m027409 · Cited by 109 · see citing works

Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

Prats, C., Donsmark, M., Qvortrup, K., Londos, C., Sztalryd, C., Holm, C., Galbo, H., & Ploug, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600247-jlr200 · Cited by 105 · see citing works

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

Park, S., Kim, H., Wang, S., Higashimori, T., Dong, J., Kim, Y. J., Cline, G. W., Li, H., Prentki, M., Shulman, G. I., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00251.2004 · Cited by 105 · see citing works

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104 · see citing works

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes

Bergman, B. C., Perreault, L., Hunerdosse, D. M., Koehler, M. C., Samek, A. M., & Eckel, R. H. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00684.2009 · Cited by 103 · see citing works

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

Schoiswohl, G., Schweiger, M., Schreiber, R., Gorkiewicz, G., Preiss-Landl, K., Taschler, U., Zierler, K. A., Radner, F. P. W., Eichmann, T. O., Kienesberger, P. C., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001073 · Cited by 103 · see citing works

Increased protein kinase C theta in skeletal muscle of diabetic patients

Itani, S. I., Pories, W. J., MacDonald, K. G., & Dohm, G. L. (2001) · Metabolism · doi:10.1053/meta.2001.22512 · Cited by 101 · see citing works

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

Levin, M. C., Monetti, M., Watt, M. J., Sajan, M. P., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., & Farese, R. V. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00158.2007 · Cited by 99 · see citing works

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

Koves, T. R., Sparks, L. M., Kovalik, J., Mosedale, M., Arumugam, R., DeBalsi, K. L., Everingham, K., Thorne, L. B., Esther Phielix, E., Meex, R. C. R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p028910 · Cited by 95 · see citing works

Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models

Girousse, A., & Langin, D. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.113 · Cited by 93 · see citing works

Relationship between plasma free fatty acid, intramyocellular triglycerides and long‐chain acylcarnitines in resting humans

Kanaley, J. A., Shadid, S., Sheehan, M. T., Guo, Z., & Jensen, M. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180695 · Cited by 92 · see citing works

Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction

MacPherson, R. E. K., Ramos, S. V., Vandenboom, R., Roy, B. D., & Peters, S. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00418.2012 · Cited by 91 · see citing works

Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training

Peters, S. J., Samjoo, I. A., Devries, M. C., Stevic, I., Robertshaw, H. A., & Tarnopolsky, M. A. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-059 · Cited by 81 · see citing works

Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity

Sitnick, M., Basantani, M., Cai, L., Schoiswohl, G., Yazbeck, C. F., Distéfano, G., Ritov, V., DeLany, J., Schreiber, R., Stolz, D., et al. (2013) · Diabetes · doi:10.2337/db13-0500 · Cited by 80 · see citing works

High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

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