Role of bile acids in metabolic control

Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery

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Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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Nonalcoholic Fatty Liver Disease

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

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The global NAFLD epidemic

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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

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Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

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Interactions Between the Intestinal Microbiome and Liver Diseases

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Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

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Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

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FXR is a molecular target for the effects of vertical sleeve gastrectomy

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Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

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Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

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Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

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Bile acid receptors as targets for drug development

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Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

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Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

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Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

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Microbiota-induced obesity requires farnesoid X receptor

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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

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The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

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Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

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The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis

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Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

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Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

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Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

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Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

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Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

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Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice

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All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons

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Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

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Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

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The Importance of Caloric Restriction in the Early Improvements in Insulin Sensitivity After Roux-en-Y Gastric Bypass Surgery

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Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis

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Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

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Bile acid levels are increased in the liver of patients with steatohepatitis

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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

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TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

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Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

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Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

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Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

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Non-alcoholic steatohepatitis: a microbiota-driven disease

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Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

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Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

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Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

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Bile acids and bariatric surgery

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Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

Kumar, D. P., Asgharpour, A., Mirshahi, F., Park, S. H., Liu, S., Imai, Y., Nadler, J. L., Grider, J. R., Murthy, K. S., & Sanyal, A. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.699504 · Cited by 144 · see citing works

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

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Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

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Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids

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Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

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Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1

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Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

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The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes

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Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

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Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

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Heritability: The family roots of obesity

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The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation

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Vertical Sleeve Gastrectomy Improves Glucose and Lipid Metabolism and Delays Diabetes Onset in UCD-T2DM Rats

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Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

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Bile acid sequestrants for glycemic control in patients with type 2 diabetes: A systematic review with meta-analysis of randomized controlled trials

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Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

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Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease

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Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial

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The Presence and Severity of Nonalcoholic Steatohepatitis Is Associated with Specific Changes in Circulating Bile Acids

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Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects

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