How non-nutritive sweeteners influence hormones and health

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · see citing works

Addressing Current Criticism Regarding the Value of Self-Report Dietary Data

Subar, A. F., Freedman, L. S., Tooze, J. A., Kirkpatrick, S. I., Boushey, C., Neuhouser, M. L., Thompson, F. E., Potischman, N., Guenther, P. M., Tarasuk, V., et al. (2015) · The Journal of Nutrition · doi:10.3945/jn.115.219634 · Cited by 1,047 · see citing works

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.

Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · see citing works

T1R3 and gustducin in gut sense sugars to regulate expression of Na ⁺ -glucose cotransporter 1

Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

den Besten, G., Lange, K., Havinga, R., van Dijk, T. H., Gerding, A., van Eunen, K., Müller, M. M., Groen, A. K., Hooiveld, G. J. E. J., Bakker, B. M., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2013 · Cited by 606 · see citing works

Sugar Absorption in the Intestine: The Role of GLUT2

Kellett, G. L., Brot‐Laroche, E., Mace, O. J., & Leturque, A. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155518 · Cited by 491 · see citing works

Evaluation of dietary assessment instruments against doubly labeled water, a biomarker of habitual energy intake

Trabulsi, J., & Schoeller, D. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e891 · Cited by 476 · see citing works

Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2

Mace, O. J., Affleck, J. A., Patel, N., & Kellett, G. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.130906 · Cited by 455 · see citing works

Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements

Swithers, S. E. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.005 · Cited by 418 · see citing works

Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies

Azad, M. B., Abou-Setta, A. M., Chauhan, B. F., Rabbani, R., Lys, J., Copstein, L., Mann, A. S., Jeyaraman, M. M., Reid, A. E., Fiander, M., et al. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.161390 · Cited by 397 · see citing works

Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies

Rogers, P. J., Hogenkamp, P. S., de Graaf, C., Higgs, S., Lluch, A., Ness, A. R., Penfold, C., Perry, R., Putz, P., Yeomans, M. R., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.177 · Cited by 358 · see citing works

Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

Abou-Donia, M. B., EL-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E., & Schiffman, S. S. (2008) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802328630 · Cited by 342 · see citing works

Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat

Palmnäs, M. S. A., Cowan, T., Bomhof, M. R., Su, J., Reimer, R. A., Vogel, H. J., Hittel, D. S., & Shearer, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109841 · Cited by 337 · see citing works

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

Nakagawa, Y. S., Nagasawa, M., Yamada, S., Hara, A., Mogami, H., Nikolaev, V. O., Lohse, M. J., Shigemura, N., Ninomiya, Y., & Kojima, I. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005106 · Cited by 308 · see citing works

A role for sweet taste: Calorie predictive relations in energy regulation by rats.

Swithers, S. E., & Davidson, T. L. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.1.161 · Cited by 296 · see citing works

Banting Lecture 2011

Corkey, B. E. (2011) · Diabetes · doi:10.2337/db11-1483 · Cited by 285 · see citing works

Consumption of Low-Calorie Sweeteners among Children and Adults in the United States

Sylvetsky, A. C., Jin, Y., Clark, E. J., Welsh, J. A., Rother, K. I., & Talegawkar, S. A. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.11.004 · Cited by 282 · see citing works

PARADOXICAL EFFECTS OF AN INTENSE SWEETENER (ASPARTAME) ON APPETITE

Blundell, J. E. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91352-8 · Cited by 279 · see citing works

Age at Menarche and Risks of All-Cause and Cardiovascular Death: A Systematic Review and Meta-Analysis

Charalampopoulos, D., McLoughlin, A., Elks, C. E., & Ong, K. K. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu113 · Cited by 267 · see citing works

Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice

Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00487 · Cited by 258 · see citing works

Programming of Host Metabolism by the Gut Microbiota

Bäckhed, F. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000328042 · Cited by 256 · see citing works

Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects

Ma, J., Bellon, M., Wishart, J. M., Young, R. L., Blackshaw, L. A., Jones, K. L., Horowitz, M., & Rayner, C. K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90708.2008 · Cited by 256 · see citing works

Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides

Steinert, R. E., Frey, F., Töpfer, A., Drewe, J., & Beglinger, C. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000512x · Cited by 255 · see citing works

Sucralose affects glycemic and hormonal responses to an oral glucose load

Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S. (2013) · Diabetes Care · doi:10.2337/dc12-2221 · Cited by 253 · see citing works

The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice

Bian, X.-M., Chi, L., Gao, B., Tu, P., Ru, H.-Y., & Lu, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178426 · Cited by 236 · see citing works

The Potential Toxicity of Artificial Sweeteners

Whitehouse, C. R., Boullata, J. I., & McCauley, L. (2008) · AAOHN Journal · doi:10.3928/08910162-20080601-02 · Cited by 233 · see citing works

Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions

Bian, X., Tu, P., Chi, L., Gao, B., Ru, H., & Lü, K. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.04.045 · Cited by 224 · see citing works

Direct and indirect cellular effects of aspartame on the brain

Humphries, P., Pretorius, E., & Naudé, H. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602866 · Cited by 220 · see citing works

Non-caloric artificial sweeteners and the microbiome: findings and challenges

Suez, J., Korem, T., Zilberman-Schapira, G., Segal, E., & Elinav, E. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1017700 · Cited by 217 · see citing works

Separate circuitries encode the hedonic and nutritional values of sugar

Téllez, L. A., Han, W., Zhang, X., Ferreira, T. L., Pérez-Martínez, I. O., Shammah‐Lagnado, S. J., van den Pol, A. N., & de Araújo, I. E. (2016) · Nature Neuroscience · doi:10.1038/nn.4224 · Cited by 215 · see citing works

Carbonated Soft Drink Consumption and Bone Mineral Density in Adolescence: The Northern Ireland Young Hearts Project

McGartland, C. P., Robson, P. J., Murray, L., Cran, G. W., Savage, M. J., Watkins, D. C., Rooney, M. E., & Boreham, C. A. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.9.1563 · Cited by 188 · see citing works

Ingestion of Diet Soda Before a Glucose Load Augments Glucagon-Like Peptide-1 Secretion

Brown, R. J., Walter, M. F., & Rother, K. I. (2009) · Diabetes Care · doi:10.2337/dc09-1185 · Cited by 169 · see citing works

Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans

Wu, T., Zhao, B. R., Bound, M. J., Checklin, H. L., Bellon, M., Little, T. J., Young, R. L., Jones, K. L., Horowitz, M., & Rayner, C. K. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.021543 · Cited by 163 · see citing works

Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index

Azad, M. B., Sharma, A., de Souza, R. J., Dolinsky, V. W., Becker, A. B., Mandhane, P. J., Turvey, S. E., Subbarao, P., Lefebvre, D. L., Sears, M. R., et al. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.0301 · Cited by 157 · see citing works

Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

Malki, A., Fiedler, J., Fricke, K., Ballweg, I., Pfaffl, M. W., & Krautwurst, D. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a0714-331rr · Cited by 153 · see citing works

Altered processing of sweet taste in the brain of diet soda drinkers

Green, E., & Murphy, C. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.05.006 · Cited by 153 · see citing works

Association between intake of artificially sweetened and sugar-sweetened beverages and preterm delivery: a large prospective cohort study

Englund‐Ögge, L., Brantsæter, A. L., Haugen, M., Sengpiel, V., Khatibi, A., Myhre, R., Myking, S., Meltzer, H. M., Kacerovský, M., Nilsen, R. M., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031567 · Cited by 146 · see citing works

Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects

Ma, J., Chang, J., Checklin, H. L., Young, R. L., Jones, K. L., Horowitz, M., & Rayner, C. K. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510001327 · Cited by 141 · see citing works

Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice

Uebanso, T., Ohnishi, A., Kitayama, R., Yoshimoto, A., Nakahashi, M., Shimohata, T., Mawatari, K., & Takahashi, A. (2017) · Nutrients · doi:10.3390/nu9060560 · Cited by 141 · see citing works

Revisiting the safety of aspartame

Choudhary, A. K., & Pretorius, E. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux035 · Cited by 140 · see citing works

Consumption of artificial sweetener– and sugar-containing soda and risk of lymphoma and leukemia in men and women

Schernhammer, E. S., Bertrand, K. A., Birmann, B. M., Sampson, L., Willett, W. C., & Feskanich, D. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030833 · Cited by 137 · see citing works

Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism

Burke, M. V., & Small, D. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.036 · Cited by 132 · see citing works

Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women

Halldorsson, T. I., Strøm, M., Petersen, S. B., & Olsen, S. F. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28968 · Cited by 131 · see citing works

Artificial Sweeteners Stimulate Adipogenesis and Suppress Lipolysis Independently of Sweet Taste Receptors

Simon, B. R., Parlee, S. D., Learman, B. S., Mori, H., Scheller, E. L., Cawthorn, W. P., Ning, X., Gallagher, K. A., Tyrberg, B., Assadi‐Porter, F. M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514034 · Cited by 129 · see citing works

Satiety scores and satiety hormone response after sucrose-sweetened soft drink compared with isocaloric semi-skimmed milk and with non-caloric soft drink: a controlled trial

Maersk, M., Belza, A., Holst, J. J., Fenger‐Grøn, M., Pedersen, S. B., Astrup, A. V., & Richelsen, B. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.223 · Cited by 124 · see citing works

Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes

Temizkan, Ş., Deyneli, O., Yasar, M., Arpa, M., Güneş, M., Yazıcı, D., Sirikci, O., Haklar, G., İmeryüz, N., & Yavuz, D. G. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.208 · Cited by 121 · see citing works

Taste perception: from the tongue to the testis

Li, F. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat009 · Cited by 120 · see citing works

Mechanisms for Sweetness

Fernstrom, J. D., Munger, S. D., Sclafani, A. J., de Araújo, I. E., Roberts, A. S., & Molinary, S. V. (2012) · Journal of Nutrition · doi:10.3945/jn.111.149567 · Cited by 114 · see citing works

Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats

Swithers, S. E., Laboy, A. F., Clark, K., Cooper, S., & Davidson, T. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.024 · Cited by 113 · see citing works

Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward

Veldhuizen, M. G., Babbs, R. K., Patel, B. P., Fobbs, W. C., Kroemer, N. B., Garcia, E., Yeomans, M. R., & Small, D. M. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.018 · Cited by 108 · see citing works

Non-Nutritive Sweeteners and their Role in the Gastrointestinal Tract

Brown, R. J., & Rother, K. I. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1475 · Cited by 106 · see citing works

Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes

Janghorbani, M., Mansourian, M., & Hosseini, E. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0579-x · Cited by 105 · see citing works

Effects of Diet Soda on Gut Hormones in Youths With Diabetes

Brown, R. J., Walter, M. F., & Rother, K. I. (2012) · Diabetes Care · doi:10.2337/dc11-2424 · Cited by 105 · see citing works

A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells

Masubuchi, Y., Nakagawa, Y. S., Ma, J., Sasaki, T., Kitamura, T., Yamamoto, Y., Kurose, H., Kojima, I., & Shibata, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054500 · Cited by 102 · see citing works

Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women

Brown, A. W., Brown, M. M. B., Onken, K. L., & Beitz, D. C. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.10.004 · Cited by 99 · see citing works

Hormonal responses to non-nutritive sweeteners in water and diet soda

Sylvetsky, A. C., Brown, R. J., Blau, J. E., Walter, M. F., & Rother, K. I. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0129-3 · Cited by 94 · see citing works

Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls

Carwile, J. L., Willett, W. C., Spiegelman, D. L., Hertzmark, E., Rich-Edwards, J. W., Frazier, A. L., & Michels, K. B. (2015) · Human Reproduction · doi:10.1093/humrep/deu349 · Cited by 86 · see citing works

Corporate Funding of Food and Nutrition Research

Nestle, M. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.6667 · Cited by 83 · see citing works

Minireview: Nutrient Sensing by G Protein-Coupled Receptors

Wauson, E., Lorente-Rodríguez, A., & Cobb, M. H. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1100 · Cited by 79 · see citing works

Amygdala response to sucrose consumption is inversely related to artificial sweetener use

Rudenga, K. J., & Small, D. M. (2011) · Appetite · doi:10.1016/j.appet.2011.12.001 · Cited by 78 · see citing works

Expression of Tas1 Taste Receptors in Mammalian Spermatozoa: Functional Role of Tas1r1 in Regulating Basal Ca2+ and cAMP Concentrations in Spermatozoa

Meyer, D., Voigt, A., Widmayer, P., Borth, H., Huebner, S., Breit, A., Marschall, S., de Angelis, M. H., Boehm, U., Meyerhof, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032354 · Cited by 77 · see citing works

Consumption of caffeinated and artificially sweetened soft drinks is associated with risk of early menarche

Mueller, N. T., Jacobs, D. R., MacLehose, R. F., Demerath, E. W., Kelly, S. P., Dreyfus, J., & Pereira, M. A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100958 · Cited by 77 · see citing works

Effects of a nonnutritive sweetener on body adiposity and energy metabolism in mice with diet-induced obesity

Mitsutomi, K., Masaki, T., Shimasaki, T., Gotoh, K., Chiba, S., Kakuma, T., & Shibata, H. (2013) · Metabolism · doi:10.1016/j.metabol.2013.09.002 · Cited by 76 · see citing works

Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass

Simon, B. R., Learman, B. S., Parlee, S. D., Scheller, E. L., Mori, H., Cawthorn, W. P., Ning, X., Krishnan, V., Ma, Y. L., Tyrberg, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086454 · Cited by 76 · see citing works

Cigarette smoking and risk of hip fracture in women: A meta-analysis of prospective cohort studies

Shen, G., Li, Y., Zhao, G., Zhou, H. B., Xie, Z. G., Xu, W., Chen, H. N., Dong, Q. R., & Xu, Y. J. (2015) · Injury · doi:10.1016/j.injury.2015.04.008 · Cited by 73 · see citing works

The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells

Kojima, I., & Nakagawa, Y. S. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.5.451 · Cited by 72 · see citing works

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility

Mosinger, B. J., Redding, K., Parker, M. R., Yevshayeva, V., Yee, K. K., Dyomina, K., Li, Y., & Margolskee, R. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302827110 · Cited by 69 · see citing works

The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity

Workman, A. D., Palmer, J. N., Adappa, N. D., & Cohen, N. A. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0571-8 · Cited by 69 · see citing works

The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice

Avau, B., Bauters, D., Steensels, S., Vancleef, L., Laermans, J., Lesuisse, J., Buyse, J. G., LIJNEN, H. R., Tack, J. F., & Depoortere, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145538 · Cited by 68 · see citing works

Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness

Kohno, D., Koike, M., Ninomiya, Y., Kojima, I., Kitamura, T., & Yada, T. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00502 · Cited by 64 · see citing works

The safety and regulatory process for low calorie sweeteners in the United States

Roberts, A. S. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.039 · Cited by 63 · see citing works

Artificial Sweeteners Have No Effect on Gastric Emptying, Glucagon-Like Peptide-1, or Glycemia After Oral Glucose in Healthy Humans

Wu, T., Bound, M. J., Standfield, S., Bellon, M., Young, R. L., Jones, K. L., Horowitz, M., & Rayner, C. K. (2013) · Diabetes Care · doi:10.2337/dc13-0958 · Cited by 61 · see citing works

What Parents Think about Giving Nonnutritive Sweeteners to Their Children: A Pilot Study

Sylvetsky, A. C., Greenberg, M. J., Zhao, X., & Rother, K. I. (2014) · International Journal of Pediatrics · doi:10.1155/2014/819872 · Cited by 59 · see citing works

Low Calorie Sweetener (LCS) use and energy balance

Peters, J. C., & Courtney, J. B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.024 · Cited by 50 · see citing works

The Antimicrobial Activity of the Three Commercially Available Intense Sweeteners against Common Periodontal Pathogens: An in vitro Study

Patil, R. B., Nagaraj, T., & Patel, V. B. (2012) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-1222 · Cited by 48 · see citing works

Nutrient-Content Claims — Guidance or Cause for Confusion?

Sylvetsky, A. C., & Dietz, W. H. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1404899 · Cited by 46 · see citing works

Soda consumption and risk of hip fractures in postmenopausal women in the Nurses’ Health Study , , ,

Fung, T. T., Arasaratnam, M. H., Grodstein, F., Katz, J. N., ROSNER, B. A., Willett, W. C., & Feskanich, D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.083352 · Cited by 44 · see citing works

Low calorie sweeteners and gut microbiota

Daly, K., Darby, A. C., & Shirazi‐Beechey, S. P. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.014 · Cited by 44 · see citing works

Effects of Daily Exposure to Saccharin and Sucrose on Testicular Biologic Functions in Mice

Gong, T., Qü, W., Mao, D., Nagaoka, K., Watanabe, G., Taya, K., & Shi, F. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.140889 · Cited by 44 · see citing works

Effect of the Artificial Sweetener, Acesulfame Potassium, a Sweet Taste Receptor Agonist, on Glucose Uptake in Small Intestinal Cell Lines

Zheng, Y., & Sarr, M. G. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1998-z · Cited by 39 · see citing works

Preterm birth and the timing of puberty: a systematic review

James, E., Wood, C. L., Nair, H., & Williams, T. C. (2018) · BMC Pediatrics · doi:10.1186/s12887-017-0976-8 · Cited by 36 · see citing works

Administration of Saccharin to Neonatal Mice Influences Body Composition of Adult Males and Reduces Body Weight of Females

Parlee, S. D., Simon, B. R., Scheller, E. L., Alejandro, E. U., Learman, B. S., Krishnan, V., Bernal‐Mizrachi, E., & MacDougald, O. A. (2014) · Endocrinology · doi:10.1210/en.2013-1995 · Cited by 32 · see citing works

Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose

Medina, J., Nakagawa, Y. S., Nagasawa, M., Fernandez, A., Sakaguchi, K., Kitaguchi, T., & Kojima, I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.729863 · Cited by 28 · see citing works

Type of sweet flavour carrier affects thyroid axis activity in male rats

Pałkowska-Goździk, E., Bigos, A., & Rosołowska‐Huszcz, D. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1367-x · Cited by 26 · see citing works

Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption

Eaton, M. S., Weinstein, N., Newby, J. B., Plattes, M. M., Foster, H. E., Arthur, J. W., Ward, T. D., Shively, S. R., Shor, R. E., Nathan, J., et al. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0596-7 · Cited by 26 · see citing works

The Sweetener-Sensing Mechanisms of the Ghrelin Cell

Steensels, S., Vancleef, L., & Depoortere, I. (2016) · Nutrients · doi:10.3390/nu8120795 · Cited by 24 · see citing works

Dental considerations in sucralose use.

Mandel, I. D., & Grotz, V. L. (2002) · PubMed · Cited by 21 · see citing works

Taste receptors in the gut tune the release of peptides in response to nutrients

Depoortere, I. (2015) · Peptides · doi:10.1016/j.peptides.2015.01.013 · Cited by 18 · see citing works

T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells

Masubuchi, Y., Nakagawa, Y. S., Medina, J., Nagasawa, M., Kojima, I., Rasenick, M. M., Inagaki, T., & Shibata, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176841 · Cited by 18 · see citing works

The Endocrine Society’s 99th Annual Meeting and Expo

(2017) · Endocrine Reviews · doi:10.1093/edrv/38.supp.1 · Cited by 15 · see citing works

Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms.

Li, L., Ohtsu, Y., Nakagawa, Y., Masuda, K., & Kojima, I. (2016) · Endocrine journal · doi:10.1507/endocrj.ej16-0217 · Cited by 11 · see citing works

Proceedings of the 2015 ASPEN Research Workshop—Taste Signaling

Spector, A. C., le Roux, C. W., Munger, S. D., Travers, S. P., Sclafani, A. J., & Mennella, J. A. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115617438 · Cited by 7 · see citing works

Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies

Qin, P., Li, Q., Zhao, Y., Chen, Q., Sun, X., Liu, Y., Li, H., Wang, T., Chen, X., Zhou, Q., et al. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00655-y · Cited by 323 · see citing works

Implications of the Westernized Diet in the Onset and Progression of IBD

Rizzello, F., Spisni, E., Giovanardi, E., Imbesi, V., Salice, M., Alvisi, P., Valerii, M. C., & Gionchetti, P. (2019) · Nutrients · doi:10.3390/nu11051033 · Cited by 251 · see citing works

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel, J., Howard, S., Agay-Shay, K., Arrebola, J., Audouze, K., Babin, P. J., Barouki, R., Bansal, A., Blanc, E. B., Cave, M., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115015 · Cited by 173 · see citing works

Intestinal Fructose and Glucose Metabolism in Health and Disease

Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 136 · see citing works

Exploiting the oral microbiome to prevent tooth decay: Has evolution already provided the best tools?

Baker, J. L., & Edlund, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03323 · Cited by 118 · see citing works

Effects of Sugar‐Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial

Ebbeling, C. B., Feldman, H. A., Steltz, S. K., Quinn, N. L., Robinson, L. M., & Ludwig, D. S. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015668 · Cited by 95 · see citing works

Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

Moriconi, E., Feraco, A., Marzolla, V., Infante, M., Lombardo, M., Fabbri, A., & Caprio, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00444 · Cited by 69 · see citing works

Reconsidering the classification of sweet taste liker phenotypes: A methodological review

Iatridi, V., Hayes, J. E., & Yeomans, M. R. (2018) · Food Quality and Preference · doi:10.1016/j.foodqual.2018.09.001 · Cited by 65 · see citing works

FTIR spectroscopy coupled with machine learning approaches as a rapid tool for identification and quantification of artificial sweeteners

Wang, Y., Li, B., Xu, X., Ren, H., Yin, J., Zhu, H., & Zhang, Y. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125404 · Cited by 64 · see citing works

Rethinking sugar reduction in processed foods

Deliza, R., Lima, M., & Ares, G. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.01.010 · Cited by 56 · see citing works

Approaches to Enhance Sugar Content in Foods: Is the Date Palm Fruit a Natural Alternative to Sweeteners?

Sayas‐Barberá, E., Paredes, C., Salgado-Ramos, M., Pallarés, N., Ferrer, E., Navarro, C., & Pérez‐Álvarez, J. Á. (2023) · Foods · doi:10.3390/foods13010129 · Cited by 44 · see citing works

Gut mechanisms linking intestinal sweet sensing to glycemic control

Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40 · see citing works

Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective

Turner, A., Veysey, M. J., Keely, S., Scarlett, C. J., Lucock, M. D., & Beckett, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17114094 · Cited by 39 · see citing works

Trends in Low-Calorie Sweetener Consumption Among Pregnant Women in the United States

Sylvetsky, A. C., Figueroa, J., Rother, K. I., Goran, M. I., & Welsh, J. A. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz004 · Cited by 35 · see citing works

Elucidation of the sweetening mechanism of sweet orange fruit aroma compounds on sucrose solution using sensory evaluation, electronic tongue, molecular docking, and molecular dynamics simulation

Xiao, Z., Gao, J., Niu, Y., Wang, Z., Zhou, R., Zhang, J., & Zhu, J. (2024) · LWT · doi:10.1016/j.lwt.2024.116555 · Cited by 33 · see citing works

Consumption of low‐calorie sweetened beverages is associated with higher total energy and sugar intake among children, NHANES 2011–2016

Sylvetsky, A. C., Figueroa, J., Zimmerman, T., Swithers, S. E., & Welsh, J. A. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12535 · Cited by 33 · see citing works

Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial

Nichol, A. D., Salamé, C., Rother, K. I., & Pepino, M. Y. (2019) · Nutrients · doi:10.3390/nu12010029 · Cited by 32 · see citing works

A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk

Hinkle, S. N., Rawal, S., Bjerregaard, A. A., Halldorsson, T. I., Li, M., Ley, S. H., Wu, J., Zhu, Y., Chen, L., Liu, A., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz094 · Cited by 28 · see citing works

Consumption of sugar‐sweetened and artificially sweetened soft drinks and risk of cancers not related to obesity

Bassett, J. K., Milne, R. L., English, D. R., Giles, G. G., & Hodge, A. M. (2019) · International Journal of Cancer · doi:10.1002/ijc.32772 · Cited by 27 · see citing works

Low-calorie sweeteners and human health: a rapid review of systematic reviews

Andrade, L., Lee, K. M., Sylvetsky, A. C., & Kirkpatrick, S. I. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa123 · Cited by 26 · see citing works

Low Doses of Sucralose Alter Fecal Microbiota in High-Fat Diet-Induced Obese Rats

Zhang, M., Chen, J., Yang, M., Cheng, Q., Liu, Y., Qi, Y., Feng, R., Yang, M., Liu, W., & Ma, J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.787055 · Cited by 25 · see citing works

The Effects of Nonnutritive Sweeteners on the Cariogenic Potential of Oral Microbiome

Zhu, J., Liu, J., Li, Z., Xi, R., Li, Y., Peng, X., Xu, X., Zheng, X. M., & Zhou, X. (2021) · BioMed Research International · doi:10.1155/2021/9967035 · Cited by 24 · see citing works

The gut odorant receptor and taste receptor make sense of dietary components: A focus on gut hormone secretion

Wang, Y., Geng, R., Zhao, Y., Fang, J., Li, M., Kang, S., Huang, K., & Tong, T. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2177610 · Cited by 24 · see citing works

Recent advance in technological innovations of sugar-reduced products

Zhang, G., Zhang, L., Ahmad, I., Zhang, J., Zhang, A., Tang, W., Ding, Y., & Lyu, F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2151560 · Cited by 24 · see citing works

Low-calorie sweeteners cause only limited metabolic effects in mice

Glendinning, J. I., Hart, S. A., Lee, H., Maleh, J., Ortiz, G., Ryu, Y. S., Sanchez, A., Shelling, S., & Williams, N. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00245.2019 · Cited by 23 · see citing works

An alternative pathway for sweet sensation: possible mechanisms and physiological relevance

von Molitor, E., Riedel, K., Krohn, M., Rudolf, R., Hafner, M., & Cesetti, T. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02467-1 · Cited by 23 · see citing works

Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice

Zhang, X., Gu, J., Zhao, C., Hu, Y., Zhang, B., Wang, J., Lv, H., Ji, X., & Wang, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06788 · Cited by 22 · see citing works

Sucralose Consumption over 2 Weeks in Healthy Subjects Does Not Modify Fasting Plasma Concentrations of Appetite-Regulating Hormones: A Randomized Clinical Trial

Romo-Romo, A., Aguilar-Salinas, C. A., López-Carrasco, M. G., Guillén-Pineda, L. E., Brito-Córdova, G. X., Gómez-Díaz, R. A., Gomez-Perez, F. J., & Almeda‐Valdés, P. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.03.018 · Cited by 19 · see citing works

Effects of psychological, sensory, and metabolic energy prime manipulation on the acute endocrine stress response in fasted women

Meier, M., Bentele, U. U., Benz, A., Denk, B., Dimitroff, S. J., Pruessner, J. C., & Unternäehrer, E. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105452 · Cited by 19 · see citing works

Sugar-Sweetened Beverages and Cancer Risk: A Narrative Review

Arroyo‐Quiroz, C., Brunauer, R., & Alavez, S. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2022.2069827 · Cited by 18 · see citing works

Effect and mechanism of green and aldehyde aroma compounds from sweet orange on sucrose sweetness perception

Xiao, Z., Wang, H., Niu, Y., Zhu, J., Yu, Y., She, Y., Zhou, R., Wang, Z., & Zhang, J. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101853 · Cited by 18 · see citing works

The complex relationship between metabolic syndrome and sweeteners

Gómez‐Fernández, A. R., Santacruz, A., & Jacobo‐Velázquez, D. A. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15709 · Cited by 17 · see citing works

Exploring Current Role of Nanotechnology Used in Food Processing Industry to Control Food Additives and their Biochemical Mechanisms

Dey, S., Samadder, A., & Nandi, S. (2021) · Current Drug Targets · doi:10.2174/1389450123666211216150355 · Cited by 18 · see citing works

Consumption of Sugar-Sweetened or Artificially Sweetened Beverages and Semen Quality in Young Men: A Cross-Sectional Study

Meldgaard, M., Brix, N., Gaml‐Sørensen, A., Ernst, A., Ramlau‐Hansen, C. H., Tøttenborg, S. S., ­Hougaard, K. S., Bonde, J. P., & Toft, G. V. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020682 · Cited by 16 · see citing works

Alteration of oral microbial biofilms by sweeteners

Jeong, G., Khan, F., Tabassum, N., & Kim, Y. (2023) · Biofilm · doi:10.1016/j.bioflm.2023.100171 · Cited by 16 · see citing works

Beware Energy Drinks: A Case of a Toxic Triad Syndrome in a Diabetic Patient With Nonalcoholic Fatty Liver Disease

Uwaifo, G. I. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.07.015 · Cited by 16 · see citing works

Non-Nutritive Sweeteners Acesulfame Potassium and Sucralose Are Competitive Inhibitors of the Human P-glycoprotein/Multidrug Resistance Protein 1 (PGP/MDR1)

Danner, L., Malard, F., Valdés, R., & Stichelen, S. O.-V. (2023) · Nutrients · doi:10.3390/nu15051118 · Cited by 15 · see citing works

Influences of non‐nutritive sweeteners on ovarian and uterine expression of T1R2 and T1R3 in peripubertal female guinea pigs

Li, J., Shen, T., Shi, F., & Fu, Y. H. H. (2020) · Animal Science Journal · doi:10.1111/asj.13348 · Cited by 13 · see citing works

Artificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose–Response Meta-Analysis of Prospective Studies

Yin, T., Li, J., Wang, Y., Liu, K., Long, T., & Cheng, L. (2022) · Nutrients · doi:10.3390/nu14214445 · Cited by 13 · see citing works

Comparación del contenido de azúcares y edulcorantes no calóricos en néctares y bebidas antes y después de implementar la ley chilena 20.606

Vilma Quitral, R., Arteaga, J., Rivera, M., Galleguillos, J., & Valdés, I. (2019) · Revista chilena de nutrición · doi:10.4067/s0717-75182019000300245 · Cited by 13 · see citing works

From Tobacco to Ultraprocessed Food: How Industry Engineering Fuels the Epidemic of Preventable Disease

Gearhardt, A. N., Brownell, K. D., & Brandt, A. M. (2026) · Milbank Quarterly · doi:10.1111/1468-0009.70066 · Cited by 11 · see citing works

Effects of artificial and natural sweeteners on host metabolic health: A double-edged sword

Xue, H., Kang, X., Hong, K., Gao, Y., Tang, Y., Lin, Y., Liu, X., Huang, W., Zhan, J., & You, Y. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117158 · Cited by 14 · see citing works

Association of the consumption of common drinks with early puberty in both sexes

Tsai, M., Lee, Y. L., & Chen, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.854477 · Cited by 11 · see citing works

A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults

Gómez-Arauz, A. Y., Bueno-Hernández, N., Palomera, L. F., Alcántara-Suárez, R., León, K. L. D., Méndez-García, L. A., Carrero-Aguirre, M., Manjarrez‐Reyna, A. N., Martínez‐Reyes, C. P., Esquivel‐Velázquez, M., et al. (2019) · Journal of Immunology Research · doi:10.1155/2019/6105059 · Cited by 11 · see citing works

Moderate intake of aspartame and sucralose with meals, but not fructose, does not exacerbate energy and glucose metabolism in estrogen-deficient rats

Ryuk, J. A., Kang, S., Daily, J. W., Ko, B., & Park, S. (2019) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.19-15 · Cited by 11 · see citing works

Drinking Non-nutritive Sweetness Solution of Sodium Saccharin or Rebaudioside a for Guinea Pigs: Influence on Histologic Change and Expression of Sweet Taste Receptors in Testis and Epididymis

Shen, T., & Li, J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.720889 · Cited by 10 · see citing works

The Impact of Non-caloric Sweeteners on Male Fertility: A Systematic Review and Narrative Synthesis in Rodent Models

Kearns, M. L., MacAindriu, F., & Reynolds, C. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.854074 · Cited by 10 · see citing works

Associations of artificially sweetened beverages, sugar-sweetened beverages, and pure fruit/vegetable juice with visceral adipose tissue mass

Yu, B., Sun, Y. B., Wang, Y., Wang, B., Tan, X., Lu, Y., Zhang, K., & Wang, N. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102871 · Cited by 10 · see citing works

Mental stress and physical activity interact with the genetic risk scores of the genetic variants related to sweetness preference in high sucrose‐containing food and glucose tolerance

Park, S., Liu, M., & Song, M. Y. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1632 · Cited by 10 · see citing works

Firm’s responses to food policies to reduce consumption of ultra-processed food and beverages: lessons from the existing evidence

Hernández, J. C. S., Jayaraman, B., Taillie, L. S., & Ng, S. W. (2025) · Food Policy · doi:10.1016/j.foodpol.2025.102975 · Cited by 9 · see citing works

The artificial sweetener Splenda intake promotes changes in expression of c-Fos and NeuN in hypothalamus and hippocampus of rats

de-la-Cruz, M., Millán‐Aldaco, D., Soriano-Nava, D. M., Drucker-Colı́n, R., & Murillo‐Rodríguez, E. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.006 · Cited by 8 · see citing works

Sugar and low/no-calorie-sweetened beverage consumption and associations with body weight and waist circumference changes in five European cohort studies: the SWEET project

Buso, M. E. C., Brouwer-Brolsma, E. M., Naomi, N. D., Ngo, J., Soedamah‐Muthu, S. S., Mavrogianni, C., Harrold, J. A., Halford, J. C. G., Raben, A., Geleijnse, J. M., et al. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03192-y · Cited by 7 · see citing works

Natural Sweetener, Glycyrrhetinic Acid 3-O-Mono-beta- d -glucuronide, for Postprandial Hyperglycemia Management

Guo, L., Zhang, M., Fei, Y., & Zhao, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07188 · Cited by 7 · see citing works

GPCR targets in type 2 diabetes

Atanes, P., & Persaud, S. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00018-0 · Cited by 7 · see citing works

Intake of sugary beverages with chronic conditions and multimorbidity: a prospective cohort study of UK Biobank

Zhang, Y., Chen, H., Lim, C. C. W., Carrillo-Larco, R. M., Yan, L. L., Mishra, G. D., Yuan, C., & Xu, X. (2023) · International Journal of Epidemiology · doi:10.1093/ije/dyad057 · Cited by 7 · see citing works

The health effects of artificial sweeteners: Towards personalized quantification and prediction through gut microbiome

Wei, Y., & Ji, B. (2023) · Eco-Environment & Health · doi:10.1016/j.eehl.2023.05.003 · Cited by 6 · see citing works

Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach.

Giuliani, C., Franceschi, C., Luiselli, D., Garagnani, P., & Ulijaszek, S. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa078 · Cited by 5 · see citing works

Associations between soft-drink consumption and lifestyle patterns in overweight and obese European adults: Feel4Diabetes Study

Reppas, K., Papamichael, M. M., Boutsikou, Τ., Cardon, G., Iotova, V., Stefanova, T., Dimova, R., Rurik, I., Radó, A. S., Liatis, S., et al. (2022) · Nutrition · doi:10.1016/j.nut.2022.111769 · Cited by 5 · see citing works

Low-Calorie Sweeteners and Reproductive Health: Evidence and Debates

Atalay, E. Ç., Demirhan, B. E., & Celep, G. S. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013315621240802055207 · Cited by 5 · see citing works

Glycemic Impact of Non-Nutritive Sweeteners in Health and Type 2 Diabetes

Rose, B. D., Kreuch, D., Wu, T., Horowitz, Rayner, C. K., Page, A. J., Miller, C., & Young, R. L. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuaf313 · Cited by 5 · see citing works

Non–Sugar-Sweetened Beverages and Risk of Chronic Diseases: An Umbrella Review of Meta-analyses of Prospective Cohort Studies

Beigrezaei, S., Raeisi‐Dehkordi, H., Vargas, J. A. H., Amiri, M., Arita, V. A., van der Schouw, Y. T., Salehi‐Abargouei, A., Muka, T., Chatelan, A., & Franco, O. H. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae135 · Cited by 6 · see citing works

Diet Sugar-Free Carbonated Soda Beverage, Non-Caloric Flavors Consumption, and Diabetic Retinopathy: Any Linkage

Mirghani, H. O., Alali, N. M., ALBalawi, H. B., & Alselaimy, R. M. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s309029 · Cited by 4 · see citing works

Children’s reaction to sugar reduced dairy desserts in the context of the implementation of nutritional warning labels: An exploratory study

Velázquez, A. L., Vidal, L., Antúnez, L., Alcaire, F., Varela, P., & Ares, G. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113001 · Cited by 4 · see citing works

Development of tropical mixed juice with low added-sugar content: Sensory and nutritional aspects

Martins, I. B. A., Barbosa, I. D. C. C., Rosenthal, A., Ares, G., & Deliza, R. (2021) · Food Science and Technology International · doi:10.1177/10820132211020844 · Cited by 6 · see citing works

Nonnutritive Sweetener Consumption, Metabolic Risk Factors, and Inflammatory Biomarkers Among Adults in the Cancer Prevention Study-3 Diet Assessment Sub-Study

Sylvetsky, A. C., Wang, Y., Reddy, A. G., Um, C. Y., Hodge, R. A., Lichtman, C. J., Mitchell, D. C., Nanavati, A., Pollak, M., Wang, Y., et al. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.03.020 · Cited by 3 · see citing works

Artificial Sweeteners Perturbed Liver Enzymes in Rat Model

Dawood, M. N., Jasim, S. A. H., Fadel, M. A., & Thanoon, I. A.-J. (2022) · Pharmacognosy Journal · doi:10.5530/pj.2022.14.135 · Cited by 3 · see citing works

Effect of Low-calorie Sweeteners on Sensory, Physicochemical, and Quality Attributes of Goldenberry (Physalis peruviana L.) Juice

Acurio, L., Toapanta, M. F. V., Tigselema, M. T. P., & Llerena, W. F. T. (2023) · Current Nutrition & Food Science · doi:10.2174/1573401319666230519142822 · Cited by 3 · see citing works

Non-nutritive sweeteners in food-drug interactions: An overview of current evidence

Danner, L., Kroenke, K., & Stichelen, S. O.-V. (2025) · Molecular Pharmacology · doi:10.1016/j.molpha.2025.100035 · Cited by 2 · see citing works

Non-nutritive Sweeteners: Implications for Consumption in Athletic Populations

Machek, S. B., & Willoughby, D. S. (2019) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000469 · Cited by 2 · see citing works

Higher sweet beverage consumption was associated with increased gestational weight gain and birth weight: A Chinese cohort study

Zhang, S., Zhang, C., Guo, J., Li, B., Li, W., Liu, J., Feng, L., & Wang, P. (2024) · Nutrition Research · doi:10.1016/j.nutres.2024.09.013 · Cited by 2 · see citing works

Sugar-sweetened beverages, low/no-calorie beverages, fruit juices intake and risks of metabolic syndrome in adults: The SWEET project

Naomi, N. D., Brouwer-Brolsma, E. M., Buso, M. E. C., Soedamah‐Muthu, S. S., Mavrogianni, C., Harrold, J. A., Halford, J. C. G., Raben, A., Geleijnse, J. M., Μanios, Y., et al. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.09.014 · Cited by 1 · see citing works

“Sugar-free” trap: Artificial sweetener acesulfame induced anxiety-like behavior in Sebastes schlegelii via disturbing bidirectional microbiota–neurotransmitter interactions

Che, G., Liu, L., Li, L., Liu, H., Liu, L., Yang, T., Deng, X., Song, N., Zong, H., Yuan, Z., et al. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.09.005 · Cited by 1 · see citing works

Short-Term Effects of Nonnutritive Sweetener (Sucralose and Saccharin) Consumption on Glycemic Control and Gut Microbiota in Patients With Type 2 Diabetes: Protocol for a Double-Blind, Randomized, Placebo-Controlled, Crossover Trial

Tan, H. S., Singh, H. K. G., Mariappan, V., Jamil, N. A., Mustapa, S. N., & Misra, S. (2025) · JMIR Research Protocols · doi:10.2196/82695 · Cited by 1 · see citing works

Sugar reduction and sweeteners to improve foods

García-Cordero, A. L., Ibarra, I. S., Ferreira, A., Rodríguez, J. A., Pateiro, M., & Santos, E. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15346-4.00004-5 · Cited by 1 · see citing works

Preoperative Exposure to Low-Calorie Sweeteners and Bariatric Surgery Outcomes

Moon, R. C., Brazzi-Smith, G., Teixeira, A. F., & Jawad, M. A. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04931-4

Biological Responses to the Consumption of Non-Nutritional Sweeteners

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