Non-caloric artificial sweeteners and the microbiome: findings and challenges
Open accessAbstract
Non-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.
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Noncaloric artificial sweeteners such as saccharin, sucralose, and aspartame alter the composition of the gut microbiome.
“Other dietary compounds known to alter the composition of the gut microbiome include noncaloric artificial sweeteners such as saccharin, sucralose, and aspartame (Suez et al., 2015), a feature with functional implications associated with the induction of glucose intolerance in mice (Suez et al., 2014).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Suez et al., 2015
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- Authors
- Suez, J., Korem, T., Zilberman-Schapira, G., Segal, E., & Elinav, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Segal, Eran
- Elinav, Eran
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2015-03-04
- Volume
- 6
- Issue
- 2
- Pages
- 149-155
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4615743
- OpenAlex
- W1499229679
- Cited by
- 217
- References
- 65
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 25 · 2023: 19 · 2022: 19 · 2021: 20 · 2020: 37 · 2019: 23 · 2018: 27 · 2017: 10 · 2016: 7
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- gut microbiota, impaired glucose tolerance, metabolic disorders, weight gain, diabetes mellitus, host-microbiome interactions, sweetener safety, human health effects
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Humans, Sweetening Agents, Glucose Intolerance, Mice
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