Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism

Burke, Mary V.; Small, Dana M.

doi:10.1016/j.physbeh.2015.05.036

Cited by 132Biochemical Analysis and Sensing TechniquesRegulation of Appetite and ObesityDiet, Metabolism, and Disease

Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism

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Burke, Mary V., Small, Dana M.·2015·Physiology & Behavior

DOI 10.1016/j.physbeh.2015.05.036PMC PMC4661139

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Abstract

Evidence linking sugar-sweetened beverage (SSB) consumption to weight gain and other negative health outcomes has prompted many individuals to resort to artificial, non-nutritive sweetener (NNS) substitutes as a means of reducing SSB intake. However, there is a great deal of controversy regarding the biological consequences of NNS use, with accumulating evidence suggesting that NNS consumption may influence feeding and metabolism via a variety of peripheral and central mechanisms. Here we argue that NNSs are not physiologically inert compounds and consider the potential biological mechanisms by which NNS consumption may impact energy balance and metabolic function, including actions on oral and extra-oral sweet taste receptors, and effects on metabolic hormone secretion, cognitive processes (e.g. reward learning, memory, and taste perception), and gut microbiota.

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[53]Bartoshuk LM Duffy VB Hayes JE Moskowitz HR Snyder DJ Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives Philos Trans R Soc Lond B Biol Sci 361 2006 1137 48 10.1098/rstb.2006.1853 16815797 PMC1642698 · DOI
[106]Swithers SE Martin AA Davidson TL High-intensity sweeteners and energy balance Physiol Behav 100 2010 55 62 10.1016/j.physbeh.2009.12.021 20060008 PMC2855968 · DOI · Paper page

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Authors: Burke, M. V., & Small, D. M.
Affiliations: Yale University (US)
University of Cologne (DE)
Corresponding author: Burke, Mary V.
Small, Dana M.
ORCID: Burke, Mary V.
Small, Dana M.
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2015-12
Volume: 152
Issue: Pt B
Pages: 381-388
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2015.05.036
PMC: PMC4661139
OpenAlex: W2134968997
Cited by: 132
References: 134
Citations by year: 2026: 9 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 18 · 2020: 11 · 2019: 14 · 2018: 19 · 2017: 15 · 2016: 10 · 2015: 1 · 2012: 1
FWCI: 1.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health ((NIDCD R01 DC006706, NIDDK R01 DK095579, NCI R01 CA180030)
NIH (T32 NS41228)
NIH Predoctoral Training Program in the Neurosciences
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: artificial sweeteners, sugar-sweetened beverages, body weight, energy balance, sweet taste receptor, metabolic hormones, reward learning, gut microbiota, taste perception, appetite regulation
MeSH terms: Gastrointestinal Microbiome, Administration, Oral, Animals, Body Weight, Drinking Behavior, Energy Metabolism, Humans, Reward, Non-Nutritive Sweeteners

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Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism

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