The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TCR Signaling: Mechanisms of Initiation and Propagation
Open accessAbstract
The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and harnessing T cells therapeutically. A hallmark of the T cell response is the ability of T cells to quantitatively respond to antigenic ligands derived from pathogens while remaining inert to similar ligands derived from host tissues. Recent studies have revealed exciting properties of the TCR and behaviors of its signaling effectors that are used to detect and discriminate between antigens. Here we highlight these recent findings, focusing on the proximal TCR signaling molecules Zap70, Lck and LAT, to provide mechanistic models and insights into the exquisite sensitivity and specificity of the TCR.
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Structure and regulation of Src family kinases
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Digital signaling and hysteresis characterize Ras activation in lymphoid cells.
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“MEK, and ultimately the MAP kinase ERK [9].”
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Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Hwang, J.-R., Byeon, Y., Kim, D., & Park, S.-G. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0435-8 · Cited by 470
The intrinsic substrate specificity of the human tyrosine kinome
Yaron-Barir, T. M., Joughin, B. A., Huntsman, E. M., Kerelsky, A., Cizin, D. M., Cohen, B. M., Regev, A., Song, J., Vasan, N., Lin, T.-Y., et al. (2024) · Nature · doi:10.1038/s41586-024-07407-y · Cited by 189
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Self-citationOptogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
Yousefi, O. S., Günther, M., Hörner, M., Chalupsky, J., Wess, M., Brandl, S. M., Smith, R. W., Fleck, C., Kunkel, T., Zurbriggen, M. D., et al. (2019) · eLife · doi:10.7554/elife.42475 · Cited by 117
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Tanaka, A., Nishikawa, H., Noguchi, S., Sugiyama, D., Morikawa, H., Takeuchi, Y., Ha, D., Shigeta, N., Kitawaki, T., Maeda, Y., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191009 · Cited by 96
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Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
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Enforced Dimerization of CD45 by the Adenovirus E3/49K Protein Inhibits T Cell Receptor Signaling
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Metadata
- Authors
- Courtney, A. H., Lo, W.-L., & Weiss, A.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 43
- Issue
- 2
- Pages
- 108-123
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2777469091
- Cited by
- 571
- References
- 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- green
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