Photosynthetic Conversion of Carbon Dioxide to Oleochemicals by Cyanobacteria: Recent Advances and Future Perspectives
Open accessAbstract
Sustainable production of biofuels and biochemicals has been broadly accepted as a solution to lower carbon dioxide emissions. Besides being used as lubricants or detergents, oleochemicals are also attractive biofuels as they are compatible with existing transport infrastructures. Cyanobacteria are autotrophic prokaryotes possessing photosynthetic abilities with mature genetic manipulation systems. Through the introduction of exogenous or the modification of intrinsic metabolic pathways, cyanobacteria have been engineered to produce various bio-chemicals and biofuels over the past decade. In this review, we specifically summarize recent progress on photosynthetic production of fatty acids, fatty alcohols, fatty alk(a/e)nes, and fatty acid esters by genetically engineered cyanobacteria. We also summarize recent reports on fatty acid and lipid metabolisms of cyanobacteria and provide perspectives for economic cyanobacterial oleochemical production in the future.
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Fatty acids and alkanes are derived from acetyl-CoA/fatty acyl-ACP metabolism, including the AAR/ADO alkane pathway.
“fatty acids and alkanes from acetyl-CoA/fatty acyl-ACP metabolism, including the AAR/ADO alkane pathway [28]”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [28]
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Engineering biology approaches for food and nutrient production by cyanobacteria
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Improved Bioproduction of 1-Octanol Using Engineered <i>Synechocystis</i> sp. PCC 6803
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Repurposing endogenous Type I-D CRISPR-Cas system for genome editing in Synechococcus sp. PCC7002
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Self-citationCyanobacterial type I CRISPR-Cas systems: distribution, mechanisms, and genome editing applications
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Self-citationWalshe, J., & Saha, S. K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060638 · Cited by 1 · see citing works
“…ethanol and isobutanol are mainly derived from pyruvate-based pathways [27], fatty acids and alkanes from acetyl-CoA/fatty acyl-ACP metabolism, including the AAR/ADO alkane pathway [28] and terpenoids from the MEP pathway, which uses pyruvate and glyceraldehyde-3-phosphate as precursors [29].”
- Authors
- Wang, L., Chen, L., Yang, S., & Tan, X.
- Affiliations
- State Key Laboratory of Biocatalysis and Enzyme Engineering (CN)
- Corresponding author
- Yang, Shihui
- Tan, Xiaoming
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2020-04-17
- Volume
- 11
- Pages
- 634-634
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC7181335
- OpenAlex
- W3016611998
- Cited by
- 42
- References
- 118
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 2
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2018YFC1801200, 31871303, U1932141, 21978071)
- Chinese Academy of Sciences (CASKLB201802)
- State Key Laboratory of Freshwater Ecology and Biotechnology (2018FB09)
- National Key Research and Development Program of China (2018YFC1801200)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- cyanobacteria, oleochemicals, biofuels, fatty acids, fatty alcohols, fatty acid esters, metabolic engineering, lipid metabolism, genetically engineered cyanobacteria
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