Engineered Liver Platforms for Different Phases of Drug Development

Can the pharmaceutical industry reduce attrition rates?

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Concordance of the toxicity of pharmaceuticals in humans and in animals

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From 3D cell culture to organs-on-chips

Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834 · see citing works

Microscale culture of human liver cells for drug development

Khetani, S. R., & Bhatia, S. N. (2008) · Nature Biotechnology · doi:10.1038/nbt1361 · Cited by 1,219 · see citing works

Idiosyncratic drug hepatotoxicity

Kaplowitz, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1750 · Cited by 1,054 · see citing works

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

Ma, X., Qu, X., Zhu, W. Z., Li, Y.-S. J., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S. E., Zanella, F., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524510113 · Cited by 881 · see citing works

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872 · see citing works

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

Wilkening, S., Stahl, F., & Bader, A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.8.1035 · Cited by 794 · see citing works

Cooperation of Liver Cells in Health and Disease

Kmieć, Z. (2001) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-56553-3 · Cited by 631 · see citing works

An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture

Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507 · see citing works

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

Xu, J. J., Henstock, P. V., Dunn, M. C., Smith, A. R., Chabot, J., & de Graaf, D. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn109 · Cited by 494 · see citing works

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

Sung, J. H., Kam, C., & Shuler, M. L. (2010) · Lab on a Chip · doi:10.1039/b917763a · Cited by 485 · see citing works

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, I., Materne, E.-M., Brincker, S., Süßbier, U., Frädrich, C., Busek, M., Sonntag, F., Sakharov, D. A., Trushkin, E. V., Tonevitsky, A. G., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc50234a · Cited by 476 · cited 1× · see citing works

Perfused multiwell plate for 3D liver tissue engineering

Domanský, K., Inman, W., Serdy, J., Dash, A., Lim, M. H. M., & Griffith, L. G. (2009) · Lab on a Chip · doi:10.1039/b913221j · Cited by 446 · see citing works

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

Oleaga, C., Bernabini, C., Smith, A. S. T., Srinivasan, B., Jackson, M., McLamb, W., Platt, V., Bridges, R., Cai, Y., Santhanam, N., et al. (2016) · Scientific Reports · doi:10.1038/srep20030 · Cited by 442 · see citing works

A microfluidic 3D hepatocyte chip for drug toxicity testing

Toh, Y., Lim, T. C., Tai, D., Xiao, G., van Noort, D., & Yu, H. (2009) · Lab on a Chip · doi:10.1039/b900912d · Cited by 422 · see citing works

Deconstructing the Drug Development Process: The New Face of Innovation

Kaitin, K. I. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.293 · Cited by 419 · see citing works

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

Frey, O., Misun, P. M., Fluri, D. A., Hengstler, J. G., & Hierlemann, A. R. (2014) · Nature Communications · doi:10.1038/ncomms5250 · Cited by 382 · see citing works

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

Bavli, D., Prill, S., Tsur, E. E., Levy, G., Cohen, M., Vinken, M., Vanfleteren, J., Jaeger, M. S., & Nahmias, Y. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522556113 · Cited by 366 · see citing works

Organotypic liver culture models: meeting current challenges in toxicity testing

LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.682115 · Cited by 363 · see citing works

Multi-cell type human liver microtissues for hepatotoxicity testing

Messner, S., Agarkova, I., Moritz, W., & Kelm, J. M. (2013) · Archives of Toxicology · doi:10.1007/s00204-012-0968-2 · Cited by 319 · see citing works

A Microscale In Vitro Physiological Model of the Liver: Predictive Screens for Drug Metabolism and Enzyme Induction

Sivaraman, A., Leach, J., Townsend, S., Iida, T., Hogan, B., Stolz, D. B., Fry, R. C., Samson, L. D., Tannenbaum, S. R., & Griffith, L. G. (2005) · Current Drug Metabolism · doi:10.2174/138920005774832632 · Cited by 312 · see citing works

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

Viravaidya‐Pasuwat, K., Sin, A., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp0341996 · Cited by 306 · see citing works

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

Takayama, K., Kawabata, K., Nagamoto, Y., Kishimoto, K., Tashiro, K., Sakurai, F., Tachibana, M., Kanda, K., Hayakawa, T., Furue, M. K., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.029 · Cited by 289 · see citing works

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

Esch, M. B., Mahler, G. J., Stokol, T., & Shuler, M. L. (2014) · Lab Chip · doi:10.1039/c4lc00371c · Cited by 281 · cited 2× · see citing works

Pluripotent stem cell-derived hepatocyte-like cells

Schwartz, R. E., Fleming, H. E., Khetani, S. R., & Bhatia, S. N. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.01.003 · Cited by 281 · see citing works

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

Kostadinova, R., Boess, F., Applegate, D., Suter, L., Weiser, T., Singer, T., Naughton, B., & Roth, A. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.01.012 · Cited by 262 · see citing works

A microfluidically perfused three dimensional human liver model

Rennert, K., Steinborn, S., Gröger, M., Ungerböck, B., Jank, A., Ehgartner, J., Nietzsche, S., Dinger, J., Kiehntopf, M., Funke, H., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.043 · Cited by 258 · see citing works

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems

Shlomai, A., Schwartz, R. E., Ramanan, V., Bhatta, A., de Jong, Y. P., Bhatia, S. N., & Rice, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412631111 · Cited by 258 · see citing works

Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective

Prueksaritanont, T., Chu, X., Gibson, C. R., Cui, D., Yee, K. L., Ballard, J. E., Cabalu, T. D., & Hochman, J. H. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9470-x · Cited by 249 · see citing works

In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor

Allen, J. W. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfi052 · Cited by 230 · see citing works

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Vernetti, L. A., Senutovitch, N., Boltz, R. C., DeBiasio, R., Shun, T. Y., Gough, A., & Taylor, D. L. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215592121 · Cited by 230 · see citing works

Long‐term maintenance of a microfluidic 3D human liver sinusoid

Prodanov, L., Jindal, R., Bale, S. S., Hegde, M., McCarty, W. J., Golberg, I., Bhushan, A., Yarmush, M. L., & Usta, O. B. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25700 · Cited by 214 · see citing works

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

Novik, E., Maguire, T. J., Chao, P., Cheng, K.-C., & Yarmush, M. L. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.11.010 · Cited by 213 · see citing works

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

March, S., Ng, S., Murugan, V., Galstian, A., Shan, J., Logan, D. J., Carpenter, A. E., Thomas, D., Sim, B. K. L., Mota, M. M., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.005 · Cited by 212 · see citing works

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

Ploß, A., Khetani, S. R., Jones, C. T., Syder, A. J., Trehan, K., Gaysinskaya, V. A., Mu, K., Ritola, K., Rice, C. M., & Bhatia, S. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915130107 · Cited by 211 · see citing works

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

Khetani, S. R., Kanchagar, C., Ukairo, O. T., Krzyzewski, S., Moore, A., Shi, J., Aoyama, S., Aleo, M. D., & Will, Y. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs326 · Cited by 208 · see citing works

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

Ware, B. R., Berger, D. R., & Khetani, S. R. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv048 · Cited by 196 · see citing works

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

Berger, D. R., Ware, B. R., Davidson, M. D., Allsup, S. R., & Khetani, S. R. (2014) · Hepatology · doi:10.1002/hep.27621 · Cited by 194 · see citing works

Introduction — Morphology of the Liver Lobule

Kmieć, Z. (2001) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-56553-3_1 · Cited by 191 · see citing works

Liver sinusoid on a chip: Long‐term layered co‐culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

Kang, Y. B., Sodunke, T. R., Lamontagne, J., Cirillo, J., Rajiv, C., Bouchard, M. J., & Noh, M. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25659 · Cited by 166 · see citing works

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

Nakao, Y., Kimura, H., Sakai, Y., & Fujii, T. (2011) · Biomicrofluidics · doi:10.1063/1.3580753 · Cited by 162 · see citing works

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

Chao, P., Maguire, T. J., Novik, E., Cheng, K.-C., & Yarmush, M. L. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.013 · Cited by 161 · see citing works

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

Dehne, E., Ramme, A. P., Terrasso, A. P., Serra, M., Alves, P. M., Brito, C., Sakharov, D. A., Tonevitsky, A., Lauster, R., & Marx, U. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.02.002 · Cited by 152 · see citing works

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

Wang, W. W., Khetani, S. R., Krzyzewski, S., Duignan, D. B., & Obach, R. S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034876 · Cited by 151 · see citing works

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

Zhou, Q., Patel, D., Kwa, T., Haque, A., Matharu, Z., Stybayeva, G., Gao, Y., Diehl, A. M., & Revzin, A. (2015) · Lab on a Chip · doi:10.1039/c5lc00874c · Cited by 138 · see citing works

Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters

Nguyen, T. V., Ukairo, O. T., Khetani, S. R., McVay, M., Kanchagar, C., Seghezzi, W., Ayanoglu, G., Irrechukwu, O., & Evers, R. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.061317 · Cited by 137 · see citing works

An On-Chip Small Intestine–Liver Model for Pharmacokinetic Studies

Kimura, H., Ikeda, T., Nakayama, H., Sakai, Y., & Fujii, T. (2015) · SLAS Technology · doi:10.1177/2211068214557812 · Cited by 136 · see citing works

Microengineered Liver Tissues for Drug Testing

Khetani, S. R., Berger, D. R., Ballinger, K. R., Davidson, M. D., Lin, C., & Ware, B. R. (2015) · SLAS Technology · doi:10.1177/2211068214566939 · Cited by 116 · see citing works

Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes

Anundi, I., Lähteenmäki, T., Rundgren, M., Moldeus, P., & Lindros, K. O. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90277-4 · Cited by 110 · see citing works

Investigation of ifosfamide nephrotoxicity induced in a liver–kidney co‐culture biochip

Snouber, L. C., Aninat, C., Grsicom, L., Madalinski, G., Brochot, C., Poleni, P. E., Razan, F., Guguen‐Guillouzo, C., Legallais, C., Corlu, A., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24707 · Cited by 109 · see citing works

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Dehne, E., Maschmeyer, I., Lorenz, A., Horland, R., Schimek, K. M. S., Busek, M., Sonntag, F., Lauster, R., & Marx, U. (2015) · Journal of Visualized Experiments · doi:10.3791/52526 · Cited by 106 · see citing works

Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips

Snouber, L. C., Bunescu, A., Naudot, M., Legallais, C., Brochot, C., Dumas, M., Elena‐Herrmann, B., & Leclerc, É. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs230 · Cited by 98 · see citing works

High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening

Kwon, S., Lee, D. W., Shah, D. A., Ku, B., Jeon, S. Y., Solanki, K., Ryan, J. D., Clark, D. S., Dordick, J. S., & Lee, M. (2014) · Nature Communications · doi:10.1038/ncomms4739 · Cited by 95 · see citing works

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

Bricks, T., Paullier, P., Legendre, A., Fleury, M., Zeller, P., Merlier, F., Anton, P. M., & Leclerc, É. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.02.005 · Cited by 91 · see citing works

Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

Lin, C., Shi, J., Moore, A., & Khetani, S. R. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.066027 · Cited by 80 · see citing works

A microfluidic cell culture array with various oxygen tensions

Peng, C., Liao, W., Chen, Y., Wu, C., & Tung, Y. (2013) · Lab on a Chip · doi:10.1039/c3lc50388g · Cited by 78 · see citing works

Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics

Matharu, Z., Patel, D., Gao, Y., Haque, A., Zhou, Q., & Revzin, A. (2014) · Analytical Chemistry · doi:10.1021/ac502383e · Cited by 77 · see citing works

96-Well Format-Based Microfluidic Platform for Parallel Interconnection of Multiple Multicellular Spheroids

Kim, J., Fluri, D. A., Kelm, J. M., Hierlemann, A. R., & Frey, O. (2014) · SLAS TECHNOLOGY · doi:10.1177/2211068214564056 · Cited by 71 · see citing works

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

Prot, J. M., Videau, O., Brochot, C., Legallais, C., Bénech, H., & Leclerc, É. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.01.054 · Cited by 66 · see citing works

Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips

Legendre, A., Baudoin, R., Alberto, G., Paullier, P., Naudot, M., Bricks, T., Brocheton, J., Jacques, S., Cotton, J., & Leclerc, É. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23466 · Cited by 60 · see citing works

Stem cell-derived liver cells for drug testing and disease modeling.

Davidson, M. D., Ware, B. R., & Khetani, S. R. (2015) · PubMed · Cited by 58 · see citing works

A Micropatterned Hepatocyte Coculture Model for Assessment of Liver Toxicity Using High-Content Imaging Analysis

Trask, O. J., Moore, A., & LeCluyse, E. L. (2014) · Assay and Drug Development Technologies · doi:10.1089/adt.2013.525 · Cited by 53 · see citing works

Hepatocyte spheroid arrays inside microwells connected with microchannels

Fukuda, J., & Nakazawa, K. (2011) · Biomicrofluidics · doi:10.1063/1.3576905 · Cited by 50 · see citing works

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Baudoin, R., Prot, J. M., Nicolas, G., Brocheton, J., Brochot, C., Legallais, C., Bénech, H., & Leclerc, É. (2012) · Xenobiotica · doi:10.3109/00498254.2012.706725 · Cited by 45 · see citing works

The application of engineered liver tissues for novel drug discovery

Lin, C., Ballinger, K. R., & Khetani, S. R. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1032241 · Cited by 43 · see citing works

The phenotypic screening pendulum swings

Mullard, A. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4783 · Cited by 43 · see citing works

An in vitro hepatic zonation model with a continuous oxygen gradient in a microdevice

Sato, A., Kadokura, K., Uchida, H., & Tsukada, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.017 · Cited by 40 · see citing works

Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device

Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., & Hayashi, S. (2015) · Cell Medicine · doi:10.3727/215517915x689056 · Cited by 35 · see citing works

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver

Davidson, M. D., Lehrer, M., & Khetani, S. R. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2014.0512 · Cited by 34 · see citing works

Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats.

Baudoin, R., Legendre, A., Jacques, S., Cotton, J., Bois, F., & Leclerc, E. (2014) · Journal of Pharmacy and Science · doi:10.1002/jps.23796 · Cited by 34 · see citing works

A microfluidic device mimicking acinar concentration gradients across the liver acinus

Shih, M.-C., Tseng, S., Weng, Y., Chu, I., & Liu, C. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9762-z · Cited by 31 · see citing works

Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro

Lee, D. W., Lee, M., Ku, B., Yi, S. H., Ryu, J., Jeon, R., & Yang, M. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1102-9 · Cited by 26 · see citing works

Spatio-Temporal Control of Hepatic Stellate Cell–Endothelial Cell Interactions for Reconstruction of Liver Sinusoids In Vitro

Kasuya, J., Sudo, R., Mitaka, T., Ikeda, M., & Tanishita, K. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0351 · Cited by 20 · see citing works

Integration of pharmacokinetic and NRF2 system biology models to describe reactive oxygen species production and subsequent glutathione depletion in liver microfluidic biochips after flutamide exposure

Leclerc, É., Hamon, J., Legendre, A., & Bois, F. Y. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.05.003 · Cited by 19 · see citing works

Print Me An Organ! Why We Are Not There Yet

Ng, W. L., Chua, C. K., & Shen, Y. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101145 · Cited by 292 · see citing works

Recent Advances in Body-on-a-Chip Systems

Sung, J. H., Wang, Y. I., Narasimhan Sriram, N., Jackson, M., Long, C., Hickman, J. J., & Shuler, M. L. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05293 · Cited by 258 · see citing works

Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

Deng, J., Wei, W., Chen, Z., Lin, B., Zhao, W., Luo, Y., & Zhang, X. (2019) · Micromachines · doi:10.3390/mi10100676 · Cited by 232 · see citing works

Microfluidic organ-on-a-chip models of human liver tissue

Moradi, E., Jalili‐Firoozinezhad, S., & Solati‐Hashjin, M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.08.041 · Cited by 206 · see citing works

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Vorrink, S. U., Zhou, Y., Ingelman-Sundberg, M., & Lauschke, V. M. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy058 · Cited by 187 · see citing works

Organs-on-chips technologies – A guide from disease models to opportunities for drug development

Monteduro, A. G., Rizzato, S., Caragnano, G., Trapani, A., Giannelli, G., & Maruccio, G. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115271 · Cited by 185 · see citing works

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Vorrink, S. U., Ullah, S., Schmidt, S., Nandania, J., Velagapudi, V., Beck, O., Ingelman‐Sundberg, M., & Lauschke, V. M. (2017) · The FASEB Journal · doi:10.1096/fj.201601375r · Cited by 172 · see citing works

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D. (2018) · ALTEX · doi:10.14573/altex.1710081 · Cited by 127 · see citing works

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

Fowler, S., Chen, W. L. K., Duignan, D. B., Gupta, A., Hariparsad, N., Kenny, J. R., Lai, W. G., Liras, J., Phillips, J. A., & Gan, J. (2020) · Lab on a Chip · doi:10.1039/c9lc00857h · Cited by 112 · see citing works

Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine

Chen, X., Zhang, Y. S., Zhang, X., & Liu, C. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.022 · Cited by 108 · see citing works

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Park, D., Lee, J., Chung, J. J., Jung, Y., & Kim, S. H. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.06.006 · Cited by 105 · see citing works

The Role of Microfluidics for Organ on Chip Simulations

Aziz, A. U. R., Geng, C., Fu, M., Yu, X.-H., Qin, K.-R., & Liu, B. (2017) · Bioengineering · doi:10.3390/bioengineering4020039 · Cited by 68 · see citing works

Mimicking Native Liver Lobule Microarchitecture In Vitro with Parenchymal and Non-parenchymal Cells Using 3D Bioprinting for Drug Toxicity and Drug Screening Applications

Janani, G., Priya, S., Dey, S., & Mandal, B. B. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c00312 · Cited by 98 · see citing works

Organs-on-chip monitoring: sensors and other strategies

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Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments

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Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

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Towards improved hepatocyte cultures: Progress and limitations

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In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform

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On-Chip Construction of Liver Lobules with Self-Assembled Perfusable Hepatic Sinusoid Networks

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Current limitations and future opportunities for prediction of DILI from in vitro

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Investigations on T cell transmigration in a human skin-on-chip (SoC) model

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Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making

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Liver–heart on chip models for drug safety

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Construction of a liver sinusoid based on the laminar flow on chip and self-assembly of endothelial cells

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3D Bioprinting: Recent Trends and Challenges

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Organoids‐On‐a‐Chip for Personalized Precision Medicine

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Engineered Livers for Infectious Diseases

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A liver-on-a-chip for hepatoprotective activity assessment

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Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement

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Organs-on-a-chip

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Combining Chemistry and Engineering for Hepatocellular Carcinoma: Nano-Scale and Smaller Therapies

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Microengineered Organ-on-a-chip Platforms towards Personalized Medicine

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Development of a Hybrid Polymer-Based Microfluidic Platform for Culturing Hepatocytes towards Liver-on-a-Chip Applications

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Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis

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The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review

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Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development

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State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC

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Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention

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A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation

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Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects

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Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity

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Characterization of liver zonation‐like transcriptomic patterns in HLCs derived from hiPSCs in a microfluidic biochip environment

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Innovations in 3D bioprinting and biomaterials for liver tissue engineering: Paving the way for tissue-engineered liver

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Liver Bioengineering: Promise, Pitfalls, and Hurdles to Overcome

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Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety

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HepaRG Maturation in Silk Fibroin Scaffolds: Toward Developing a 3D In Vitro Liver Model

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Three dimensional polyvinyl alcohol scaffolds modified with collagen for HepG2 cell culture

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Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

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Generation of Scalable Hepatic Micro-Tissues as a Platform for Toxicological Studies

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Development of improved SRC-3 inhibitors as breast cancer therapeutic agents

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Vat photopolymerization‐based bioprinting: Shaping next‐generation tissues with light

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Human Liver Spheroids in Chemically Defined Conditions for Studies of Gene–drug, Drug–Drug and Disease–Drug Interactions

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Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity

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From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases

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Acute radiation syndrome drug discovery using organ-on-chip platforms

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Estimating Hepatotoxic Doses Using High-Content Imaging in Primary Hepatocytes

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A simplified 3D liver microsphere tissue culture model for hepatic cell signaling and drug-induced hepatotoxicity studies

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Glucose and lipid metabolism screening models of hepatocyte spheroids after culture with injectable fiber fragments

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Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages

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A functional long‐term 2D serum‐free human hepatic in vitro system for drug evaluation

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Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications

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P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals

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The native liver as inspiration to create superior in vitro hepatic models

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Influence of lyophilization primary drying time and temperature on porous silk scaffold fabrication for biomedical applications

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Real-time measurement of cholesterol secreted by human hepatocytes using a novel microfluidic assay

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A Low-Interference, High-Resolution Multianalyte Electrochemical Biosensor

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Next-generation experimental and computational strategies for drug-drug interaction prophecy

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Recapitulating the liver niche in vitro

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КЛЕТОЧНЫЕ ТЕХНОЛОГИИ В ФАРМАКОЛОГИЧЕСКИХ ИССЛЕДОВАНИЯХ. НАСТОЯЩЕЕ И БУДУЩЕЕ, "Цитология"

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Construction of polysaccharide scaffold-based perfusion bioreactor supporting liver cell aggregates for drug screening

Cao, L., Zhao, H., Qian, M., Shao, C., Zhang, Y., & Yang, J. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2102715 · Cited by 4 · see citing works

Fabrication of oxygen‐carrying microparticles functionalized with liver ECM‐proteins to improve phenotypic three‐dimensional in vitro liver assembly, function, and responses

Mansouri, M., Imes, W. D., Roberts, O. S., & Leipzig, N. D. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28456 · Cited by 4 · see citing works

Modelling Cardiovascular Diseases Using Human Microphysiological Systems

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Liver-on-a-Chip

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Cell‐embedded microgels as emerging miniature 3D tissue‐mimics toward biochip‐based toxicity screening

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Multicellular systems to translate somatic cell genome editors to human

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Cryopreservation of Hepatocyte Organoid-Derived Cells Generated from Human iPS Cells

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Assessment of the toxicity of copper oxide nanoparticle in the liver of male rats: Ameliorative efficacy of curcumin and its nanoparticles

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Preparation and Culture of Human Liver Resident Immune Cells

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Future Therapeutic Approaches for Alagille Syndrome

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Hepatocytes and Endothelial Networks in a Fluid-Based In Vitro Model of Liver Drug Metabolism

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Using organ-on-chip related approaches for immune cell migration research

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Human iPSCs for modeling of hepatobiliary development and drug discovery

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Application of in vitro models for pediatric translational research

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Fabrication a Natural 3D-scaffold by Mixing Collagen and Decellularized Mouse Liver Extracellular Matrix for Tissue Engineering

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Alternatives to animal models in gastroenterology and hepatology research

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A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

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Advances in the application of biofabrication: 3D bioprinting of living materials

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Hepatic–Renal Cascade Clearable Aminopeptidase N Probe for Rapid Detection of Early-Stage Liver Disease

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Liver-on-a-chip

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Engineered Liver Platforms for Different Phases of Drug

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Microengineered Liver Tissues for Drug Testing

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Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

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Engineered Human Liver Cocultures for Investigating Drug-Induced Liver Injury

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Latest impact of engineered human liver platforms on drug development

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