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Cited by 963D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsTissue Engineering and Regenerative Medicine

Organs-on-chip monitoring: sensors and other strategies

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Kilic, Tugba, Navaee, Fatemeh, Stradolini, Francesca, Renaud, Philippe, Carrara, Sandro·2018·Microphysiological Systems
DOI 10.21037/mps.2018.01.01
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Abstract

As a paradigm shifting player of tissue engineering, organs-on-chips (OOCs) are considered to hold great potential for future “clinical trials on chip” as well as a step forward to design personalized medicine. Despite all ethical concerns raised by community and suspicious attitude of medical authorities, the field keeps evolving with a remarkable speed. Although the majority of efforts have been made on making OOCs more physiologically relevant via 3D cell culture techniques, incorporation of smart biomaterial matrices and microfluidic designs, considerable amount of studies have also been focused on these providing monitoring tools to these platforms. The aim of this review is to provide, for the first time, a comprehensive report on already available methods for monitoring OOCs. In that regard, this paper critically reviews physical, chemical and biochemical sensors that have been implemented for OOCs and cell culture monitoring by also discussing the advantages and disadvantages associated with each proposed method.

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Cited by

Sorted by citations

Authors
Kilic, T., Navaee, F., Stradolini, F., Renaud, P., & Carrara, S.
Affiliations
École Polytechnique Fédérale de Lausanne (CH)
ORCID
Venue
Microphysiological Systems
Publisher
AME Publishing Company
Published
2018
Volume
1
Pages
1-1
ISSN
2616-275X (ISSN-L)
DOI
10.21037/mps.2018.01.01
OpenAlex
W2791636711
Cited by
96
References
14
Citations by year
2026: 9 · 2025: 10 · 2024: 5 · 2023: 13 · 2022: 21 · 2021: 18 · 2020: 9 · 2019: 8 · 2018: 3
FWCI
3.80
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Microphysiological Systems (publishedVersion, cc-by-nc-nd)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
organ-on-a-chip, monitoring, sensors, cell culture monitoring, microfluidics, 3D cell culture, smart biomaterials, physical sensors, chemical sensors, biochemical sensors, personalized medicine

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