Cited by 133Supramolecular Self-Assembly in MaterialsSilk-based biomaterials and applicationsTissue Engineering and Regenerative Medicine

Peptidic Biomaterials: From Self-Assembling to Regenerative Medicine

Pugliese, Raffaele, Gelain, Fabrizio·2017·Trends in Biotechnology

Abstract

Peptidic biomaterials represent a particularly exciting topic in regenerative medicine. Peptidic scaffolds can be specifically designed for biomimetic customization for targeted therapy. The field is at a pivotal point where preclinical research is being translated into clinics, so it is crucial to understand the theory and describe the status of this rapidly developing technology. In this review, we highlight major advantages and current limitations of self-assembling peptide-based biomaterials, and we discuss the most widely used classes of assembling peptides, describing recent and promising approaches in tissue engineering, drug delivery, and clinics. We also suggest design strategies and hurdles that still need to be overcome to fully exploit their therapeutic potential.

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Crossref · 10.1016/j.tibtech.2016.09.004

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Authors
Pugliese, R., & Gelain, F.
Affiliations
Casa Sollievo della Sofferenza (IT)
Corresponding author
Gelain, Fabrizio
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2017-02
Volume
35
Issue
2
Pages
145-158
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2528463570
Cited by
133
References
77
Citations by year
2026: 4 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 11 · 2016: 1
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
self-assembling peptides, peptide scaffolds, regenerative medicine, tissue engineering, drug delivery, biomimetic scaffolds, clinical translation
MeSH terms
Extracellular Matrix, Peptides, Protein Binding, Tissue Engineering, Biomimetic Materials, Nanocapsules, Tissue Scaffolds

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