Peptidic Biomaterials: From Self-Assembling to Regenerative Medicine
Abstract
Peptidic biomaterials represent a particularly exciting topic in regenerative medicine. Peptidic scaffolds can be specifically designed for biomimetic customization for targeted therapy. The field is at a pivotal point where preclinical research is being translated into clinics, so it is crucial to understand the theory and describe the status of this rapidly developing technology. In this review, we highlight major advantages and current limitations of self-assembling peptide-based biomaterials, and we discuss the most widely used classes of assembling peptides, describing recent and promising approaches in tissue engineering, drug delivery, and clinics. We also suggest design strategies and hurdles that still need to be overcome to fully exploit their therapeutic potential.
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Self-citationAntimicrobial d -Peptide Hydrogels
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Self-citationBiomimetic Self-Assembling Peptide Hydrogels for Tissue Engineering Applications
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Water‐Dispersible Polydopamine‐Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
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Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides
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Self-citationPeptide-Based Hydrogels: Template Materials for Tissue Engineering
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Self-citationMimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair
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Self-citationSelf-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke
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“Ad-ditionally, growth factor-derived peptides have been explored as adjunct therapies to PRP, demonstrating enhanced wound healing and tendon regeneration [101,102].”
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Self-citationGenerative Artificial Intelligence for Advancing Discovery and Design in Biomateriomics
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Self-citationHydrodynamic Mixing Tunes the Stiffness of Proteoglycan‐Mimicking Physical Hydrogels
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Boosted Cross-Linking and Characterization of High-Performing Self-Assembling Peptides
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- Authors
- Pugliese, R., & Gelain, F.
- Affiliations
- Casa Sollievo della Sofferenza (IT)
- Corresponding author
- Gelain, Fabrizio
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 35
- Issue
- 2
- Pages
- 145-158
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2528463570
- Cited by
- 133
- References
- 77
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 21 · 2019: 16 · 2018: 19 · 2017: 11 · 2016: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- self-assembling peptides, peptide scaffolds, regenerative medicine, tissue engineering, drug delivery, biomimetic scaffolds, clinical translation
- MeSH terms
- Extracellular Matrix, Peptides, Protein Binding, Tissue Engineering, Biomimetic Materials, Nanocapsules, Tissue Scaffolds
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