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The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain
Open accessAbstract
Research on cognitive aging has focused on how decline in various cortical and hippocampal regions influence cognition. However, brainstem regions play essential modulatory roles, and new evidence suggests that among these, the integrity of the locus coeruleus-norepinephrine system plays a key role in determining late life cognitive abilities. The locus coeruleus is especially vulnerable to toxins and infection and is often the first place Alzheimer’s related pathology appears, with most people showing at least some tau pathology by their mid-twenties. On the other hand, norepinephrine released from the locus coeruleus during arousing, mentally challenging or novel situations helps protect neurons from damage, which may help explain how education and engaging careers prevent cognitive decline in later years.
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Metadata
- Authors
- Mather, M., & Harley, C. W.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 20
- Issue
- 3
- Pages
- 214-226
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W2276238108
- Cited by
- 492
- References
- 24
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- green
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