Histone acetylation and deacetylation in yeast
Abstract
Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair and heterochromatin formation. Interestingly, specific acetylatable lysines can function as binding sites for regulatory factors. Moreover, histone deacetylation is not only repressive but can be required for gene activity.
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The emerging role of Krebs cycle intermediates opens the possibility of manipulating levels and impacts of mitochondrial metabolites within the matrix, the rest of the cell, or after release into circulation.
“the emerging role of Krebs cycle intermediates in many central biomedical pathways opens up the possibility of extending mitochondrial pharmacology164-167 to manipulating the levels and impacts of mitochondrial metabolites both within the matrix, the rest of the cell, or following their release from the cell into the circulation.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [167]
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- Authors
- Kurdistani, S. K., & Grunstein, M.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Grunstein, Michael
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2003-04
- Volume
- 4
- Issue
- 4
- Pages
- 276-284
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2005928381
- Cited by
- 677
- References
- 91
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 11 · 2023: 12 · 2022: 22 · 2021: 21 · 2020: 25 · 2019: 13 · 2018: 24 · 2017: 22 · 2016: 28 · 2015: 27 · 2014: 31 · 2013: 24 · 2012: 36
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- histone acetylation, histone deacetylation, Saccharomyces cerevisiae, histone acetyltransferase, histone deacetylase, promoter, nucleosome, transcriptional regulation, DNA replication, DNA repair, heterochromatin formation, chromatin regulation
- MeSH terms
- Acetyltransferases, Histone Deacetylases, Models, Genetic, Promoter Regions, Genetic, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Gene Expression Regulation, Enzymologic, Oligonucleotide Array Sequence Analysis, Saccharomyces cerevisiae Proteins, Histone Acetyltransferases
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