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Biogenesis and function of nuclear bodies

Open access
Mao, Yuntao S., Zhang, Bin, Spector, David L.·2011·Trends in Genetics

Abstract

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and paraspeckles are membrane-less subnuclear organelles. They are steady-state structures that dynamically respond to basic physiological processes as well as various forms of stress, altered metabolic conditions and alterations in cellular signaling. The formation of specific nuclear bodies has been suggested to follow stochastic and ordered assembly models. In addition, a seeding mechanism has been proposed to assemble, maintain, and regulate particular nuclear bodies. In coordination with noncoding RNAs, chromatin modifiers and other machineries, various nuclear bodies have been shown to sequester and modify proteins, process RNAs and assemble ribonucleoprotein complexes, as well as epigenetically regulate gene expression. Understanding the functional relationships between the three-dimensional organization of the genome and nuclear bodies is essential to fully uncover the regulation of gene expression and its implications in human diseases.

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Crossref · 10.1016/j.tig.2011.05.006

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Metadata

Authors
Mao, Y. S., Zhang, B., & Spector, D. L.
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2011-08
Volume
27
Issue
8
Pages
295-306
ISSN
0168-9525 (ISSN-L)
OpenAlex
W2083260329
Cited by
703
References
7
FWCI
3.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Biogenesis and function of nuclear bodies. https://app.cochat.ai/papers/10.1016/j.tig.2011.05.006
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Mao, Y. S., Zhang, B., & Spector, D. L. (2011). Biogenesis and function of nuclear bodies. Trends in Genetics. https://doi.org/10.1016/j.tig.2011.05.006

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