Cited by 312Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisBacterial Genetics and Biotechnology

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ESAT-6 proteins: protective antigens and virulence factors?

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Brodin, Priscille, Rosenkrands, Ida, Andersen, Peter, Cole, Stewart T., Brosch, Roland·2004·Trends in Microbiology

DOI 10.1016/j.tim.2004.09.007

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Abstract

The 6kDa early secreted antigenic target from Mycobacterium tuberculosis, ESAT-6, is the prototype of a novel family of small proteins of unknown function produced by Actinobacteria. Export of ESAT-6, a potent T-cell antigen, and related proteins requires a dedicated secretory apparatus that is encoded by a cluster of genes, several of which also code for proteins that are recognized strongly by T cells. ESAT-6 systems can thus be considered as immunogenicity islands and there is growing evidence that the corresponding genes are subject to selective pressure imposed by the immune system of the host. Recently, there has been major progress in understanding the biogenesis, secretion and antigenicity of ESAT-6 proteins and, at least in the case of ESAT-6 system 1, in unravelling their role in pathogenicity. Here, we discuss these findings and their implications for the development of new therapeutic and prophylactic interventions against tuberculosis.

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Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6
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Olsen, A.W. et al. Protective effect of a tuberculosis subunit vaccine based on a fusion of Ag85B and ESAT-6 in the aerosol guinea pig model. Infect. Immun. (in press)

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Authors: Brodin, P., Rosenkrands, I., Andersen, P., Cole, S. T., & Brosch, R.
Affiliations: Institut Pasteur (FR)
Statens Serum Institut (DK)
Corresponding author: Cole, Stewart T.
ORCID: Brodin, Priscille
Rosenkrands, Ida
Andersen, Peter
Cole, Stewart T.
Brosch, Roland
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2004-11
Volume: 12
Issue: 11
Pages: 500-508
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2004.09.007
OpenAlex: W2032564365
Cited by: 312
References: 75
Citations by year: 2026: 3 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 21 · 2015: 13 · 2014: 17 · 2013: 17 · 2012: 22
FWCI: 3.17
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: ESAT-6, Mycobacterium tuberculosis, protective antigen, virulence factors, T cell antigens, protein secretion, tuberculosis treatment, tuberculosis prophylaxis, actinobacteria
MeSH terms: Antigens, Bacterial, Bacterial Proteins, Humans, Mycobacterium tuberculosis, Tuberculosis, Protein Transport, Virulence Factors

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ESAT-6 proteins: protective antigens and virulence factors?

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