The nature of systems biology

Initial sequencing and analysis of the human genome

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Cluster analysis and display of genome-wide expression patterns

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The sequence of the human genome

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Network biology: understanding the cell's functional organization

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Network motifs: simple building blocks of complex networks.

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Functional organization of the yeast proteome by systematic analysis of protein complexes

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Hierarchical Organization of Modularity in Metabolic Networks

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The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

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Towards a proteome-scale map of the human protein–protein interaction network

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Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

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The control of flux.

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A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

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Summing up the noise in gene networks

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Metabolomics by numbers: acquiring and understanding global metabolite data

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Understanding the control of metabolism

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Robustness in bacterial chemotaxis

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Robust perfect adaptation in bacterial chemotaxis through integral feedback control

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Genome-scale models of microbial cells: evaluating the consequences of constraints

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Oscillatory behavior in enzymatic control processes

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Parameter estimation in biochemical pathways: a comparison of global optimization methods

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Noise Propagation in Gene Networks

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Metabolic network structure determines key aspects of functionality and regulation

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A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

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Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology

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Functional genomic hypothesis generation and experimentation by a robot scientist

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Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

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The evolution of molecular biology into systems biology

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Bow ties, metabolism and disease

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Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

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Thermodynamics and control of biological free-energy transduction

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Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data

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Thermodynamics and control of biological free-energy transduction

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Reconstruction of genetic circuits

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Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway

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Protein interaction networks from yeast to human

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Role of Transcriptional Regulation in Controlling Fluxes in Central Carbon Metabolism of Saccharomyces cerevisiae

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A systematic approach to modeling, capturing, and disseminating proteomics experimental data

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That Was the Molecular Biology That Was

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Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes

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Control of MAPK signalling: from complexity to what really matters

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A Linear Steady-State Treatment of Enzymatic Chains. A Mathematical Model of Glycolysis of Human Erythrocytes

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Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops

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Compartmentation protects trypanosomes from the dangerous design of glycolysis

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Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control

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A Quantitative Approach to Catabolite Repression in Escherichia coli

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Experimental and in Silico Analyses of Glycolytic Flux Control in Bloodstream Form Trypanosoma brucei

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Linking the genes: inferring quantitative gene networks from microarray data

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Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories

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Unraveling the complexity of flux regulation: A new method demonstrated for nutrient starvation in Saccharomyces cerevisiae

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Metabolic Control Mechanisms

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Modular Response Analysis of Cellular Regulatory Networks

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A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions

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Metabolic Control Mechanisms

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The Organization of Metabolic Reaction Networks

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Integrated Assessment and Prediction of Transcription Factor Binding

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Transcriptional, translational and metabolic regulation of glycolysis in Lactococcus lactis subsp. cremoris MG 1363 grown in continuous acidic cultures

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The Organization of Metabolic Reaction Networks

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The multifarious short‐term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica

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Hierarchical and metabolic regulation of glucose influx in starved

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Signal processing at the Ras circuit: what shapes Ras activation patterns?

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Metabolic engineering in the post genomic era

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The Silicon Cell initiative: working towards a detailed kinetic description at the cellular level

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On the complete determination of biological systems

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Yeast glycolytic oscillations that are not controlled by a single oscillophore: a new definition of oscillophore strength

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Tyr-317 Phosphorylation Increases Shc Structural Rigidity and Reduces Coupling of Domain Motions Remote from the Phosphorylation Site as Revealed by Molecular Dynamics Simulations

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Response experiments for nonlinear systems with application to reaction kinetics and genetics

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Origins of Molecular Biology

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‘Slave’ metabolites and enzymes

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Time-dependent hierarchical regulation analysis: deciphering cellular adaptation

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Challenges and prospects in the analysis of large-scale gene expression data

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Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry.

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The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment

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High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins

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A bioinformatics view of zinc enzymes

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Alternative Strategies for Microbial Remediation of Pollutants via Synthetic Biology

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