The pig: a model for human infectious diseases
Open accessAbstract
An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of anatomy, genetics and physiology, and represent an excellent animal model to study various microbial infectious diseases. Indeed, experiments in pigs are much more likely to be predictive of therapeutic treatments in humans than experiments in rodents. In this review, we highlight the numerous advantages of the pig model for infectious disease research and vaccine development and document a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge to improve both animal and human health.
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The domestic pig is a large animal model that exhibits relevant physiological and anatomical similarities to humans.
“We next analyzed immunogenicity in domestic pigs, a large animal model that exhibits relevant physiological and anatomical similarities to humans [44,45].”
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“We next analyzed immunogenicity in domestic pigs, a large animal model that exhibits relevant physiological and anatomical similarities to humans [44,45].”
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- Authors
- Meurens, F., Summerfield, A., Nauwynck, H., Saif, L., & Gerdts, V.
- Affiliations
- Infectiologie et santé publique (FR)
- Institut für Virologie und Immunologie (CH)
- Ghent University (BE)
- The Ohio State University (US)
- University of Saskatchewan (CA)
- Corresponding author
- Meurens, François
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 20
- Issue
- 1
- Pages
- 50-57
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC7173122
- OpenAlex
- W1982952028
- Cited by
- 999
- References
- 84
- Citations by year
- 2026: 55 · 2025: 66 · 2024: 64 · 2023: 73 · 2022: 132 · 2021: 103 · 2020: 73 · 2019: 76 · 2018: 78 · 2017: 77 · 2016: 50 · 2015: 57 · 2014: 54 · 2013: 23 · 2012: 16
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- pigs, human infectious diseases, microbial infection, vaccine development, translational research
- MeSH terms
- Animals, Anti-Infective Agents, Communicable Diseases, Disease Models, Animal, Humans, Vaccination, Vaccines, Sus scrofa
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