Cited by 999Animal testing and alternativesXenotransplantation and immune responseVeterinary medicine and infectious diseases

The pig: a model for human infectious diseases

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Meurens, François, Summerfield, Artur, Nauwynck, Hans, Saif, Linda, Gerdts, Volker·2012·Trends in Microbiology

Abstract

An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of anatomy, genetics and physiology, and represent an excellent animal model to study various microbial infectious diseases. Indeed, experiments in pigs are much more likely to be predictive of therapeutic treatments in humans than experiments in rodents. In this review, we highlight the numerous advantages of the pig model for infectious disease research and vaccine development and document a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge to improve both animal and human health.

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  1. [51]Green K.Y. Caliciviridae: the Noroviruses Knipe D.M. Howley P.M. Fields Virology 5th edn 2007 Lippincott Williams & Wilkins pp. 949–979

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Authors
Meurens, F., Summerfield, A., Nauwynck, H., Saif, L., & Gerdts, V.
Affiliations
  • Infectiologie et santé publique (FR)
  • Institut für Virologie und Immunologie (CH)
  • Ghent University (BE)
  • The Ohio State University (US)
  • University of Saskatchewan (CA)
Corresponding author
Meurens, François
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2012-01
Volume
20
Issue
1
Pages
50-57
ISSN
0966-842X (ISSN-L)
OpenAlex
W1982952028
Cited by
999
References
84
Citations by year
2026: 55 · 2025: 66 · 2024: 64 · 2023: 73 · 2022: 132 · 2021: 103 · 2020: 73 · 2019: 76 · 2018: 78 · 2017: 77 · 2016: 50 · 2015: 57 · 2014: 54 · 2013: 23 · 2012: 16
FWCI
5.61
Type
journal article
Language
en
Open access
Locations
  • Trends in Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
Keywords
pigs, human infectious diseases, microbial infection, vaccine development, translational research
MeSH terms
Animals, Anti-Infective Agents, Communicable Diseases, Disease Models, Animal, Humans, Vaccination, Vaccines, Sus scrofa

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