Orbitofrontal cortex, decision-making and drug addiction

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845

Untitled work

(1996) · Cited by 3,692

The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans

Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627

The prefrontal cortex

Fuster, J. M. (1997) · Cited by 2,095

Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making

Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001

Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory

Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960

Preliminary analysis of functions of the temporal lobes in monkeys

KLÜVER, H. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270240017001 · Cited by 1,696

The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.

Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536

Dissociation in prefrontal cortex of affective and attentional shifts

Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527

Relative reward preference in primate orbitofrontal cortex

Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314

BASAL GANGLIA PATHWAYS: BEYOND THE CLOSED-LOOP CIRCUITS WITH THE CEREBRAL CORTEX

Bostan, A. C. (2013) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2

Brain Morphology Predictors of Alcohol, Tobacco, and Cannabis Use in Adolescence: A Systematic ReviewPreprint

Boer, O. D., Marroun, H. E., & Franken, I. H. A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4120189 · Cited by 2

Neuroscience: Reevaluating the Role of Orbitofrontal Cortex

Sleezer, B. J., & Hayden, B. Y. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.063 · Cited by 1

Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder

Köhler, R., Zhornitsky, S., Potenza, M. N., Yip, S. W., Worhunsky, P. D., & Angarita, G. A. (2024) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2024.2318585 · Cited by 1

Common and Distinct Neural Connectomes Between Thought Control Ability and Happiness

Shi, L. (2025) · Journal of Happiness Studies · doi:10.1007/s10902-025-00865-9 · Cited by 1

Effects of Drumming-Based Cognitive and Physical Training on Cognitive Performance and Brain Activity in Older Adults: A Randomized Controlled Trial

Nam, Y.-G., & Kwon, B. S. (2025) · Applied Sciences · doi:10.3390/app15095062 · Cited by 1

Increased risk of suicide in substance use disorder: a neurobiological perspective

Thippaiah, S. M., Wang, M., Ransdell, M., Tang, Y., & Fanous, A. H. (2026) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2026.2618990 · Cited by 1

The effects of rTMS over orbitofrontal cortex on cognitive functions in first-episode schizophrenia

Hu, Q., Jiao, X., Ding, Y., Wei, Y., Tang, X., Xu, L., Cui, H., Tang, Y., Liu, H., Gao, J., et al. (2026) · Psychological Medicine · doi:10.1017/s0033291726103912 · Cited by 1

Role of Prefrontal Cortex Dopamine and Noradrenaline Circuitry in Addiction

Carboni, E., Cadeddu, R., & Rosa, A. (2012) · InTech eBooks · doi:10.5772/51221 · Cited by 1

Neurobiologische und kognitive Grundlagen der Sucht

Yalachkov, Y., Kaiser, J., Roeper, J., & Naumer, M. J. (2012) · Zeitschrift für Psychiatrie Psychologie und Psychotherapie · doi:10.1024/1661-4747/a000118 · Cited by 1

Examination of Methamphetamine Reinstatement in Female and Male Rats: A Pre-Clinical Model of Relapse

Pittenger, S. T. (2016) · Lincoln (University of Nebraska) · Cited by 1

Impulse Control Disorders in Neurological Settings

Bechara, A. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195389715.013.0126 · Cited by 1

Group-level analysis of tDCS induced electric field with different electrode montages in participants with methamphetamine-use disorders

Soleimani, G., Saviz, M., Towhidkhah, F., & Ekhtiari, H. (2019) · National and International Iranian Conference on Biomedical Engineering (ICBME) · doi:10.1109/icbme49163.2019.9030377 · Cited by 1

Prevention and Treatment of Work Addiction

Quiñones, C., & Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.028 · Cited by 2

Telencefalo: neocortex

Nieuwenhuys, R., Voogd, J., van Huijzen, C., & Papa, M. (2010) · Springer eBooks · doi:10.1007/978-88-470-1140-3_15 · Cited by 1

Concepts of Addiction

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.003 · Cited by 1

Linking the neural correlates of addiction and negative urgency

Halcomb, M., Yoder, K. K., & Cyders, M. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_30-1 · Cited by 1

Linking the Neural Correlates of Addiction and Negative Urgency

Halcomb, M., Yoder, K. K., & Cyders, M. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_30 · Cited by 1

Gender as a Moderator in the Association between Childhood Trauma and Risk-Taking Propensity

Huggins, A. A., Gorka, S. M., & Shankman, S. A. (2018) · Graduate Student Journal of Psychology · doi:10.52214/gsjp.v17i.10916 · Cited by 1

Potential Backgrounds Behind the Simultaneous Presence of Behavioral Changes and Spontaneous Confabulation after Orbitofrontal / ventromedial Prefrontal Cortex Injury

Funayama, M. (2023) · Higher Brain Function Research · doi:10.2496/hbfr.43.172 · Cited by 1

Reading emotions from language: A hypothesis on their reciprocal relationship

Lin, W., Huang, J.-Y., Hsu, I. L., & Lee, C. (2024) · The Psychology of learning and motivation/The psychology of learning and motivation · doi:10.1016/bs.plm.2024.03.004 · Cited by 1

Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks

Kim, C. M., Chow, C. C., & Averbeck, B. B. (2024) · eLife · doi:10.7554/elife.103660.3 · Cited by 2

Neurobiological Research on Addiction

Carter, A., Hall, W., Capps, B., & Daglish, M. R. C. (2009) · Cited by 1

Neurophysiology

Fuster, J. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373644-4.00006-2 · Cited by 1

Measurement of Brain Activity during Facial Self-touching by Near-infrared Spectroscopy

Toriyama, S., Sadachi, H., & NAKAMURA, J. (2020) · Transactions of Japan Society of Kansei Engineering · doi:10.5057/jjske.tjske-d-20-00001 · Cited by 1

Adolescent Drug Misuse Prevention: Challenges in School-Based Programming

Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.021 · Cited by 1

Measurement, Prevention, and Treatment of Exercise Addiction

Hausenblas, H. A., Mann, D. T. Y., & Downs, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.036 · Cited by 2

Brain Alterations Potentially Associated with Aggression and Terrorism

Bogerts, B., Schöne, M., & Breitschuh, S. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108569095.010 · Cited by 1

The Effects of Chronic Cocaine Self-Administration on Cognition and Brain Metabolism

Porter, J. N. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1

Perception and action in nicotine addiction : fMRI and behavioral studies of sensorimotor and multisensory processes in smokers and non-smokers

Yalachkov, Y. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20110317yy · Cited by 1

Does HIV-1/AIDS-associated frontotemporal neuropathology following perinatal infection influence the development of moral behaviour?

Gericke, G. S. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2006.05.074 · Cited by 1

Characterising trait anxiety in the common marmoset (Callithrix jacchus): investigations into behavioural, psychophysiological and cognitive phenotypes

Shiba, Y. (2013) · Apollo (University of Cambridge) · doi:10.17863/cam.28 · Cited by 1

Developing translational animal models for decision making: the Iowa Gambling Task case

Mitsogiannis, M. D. (2011) · Utrecht University Repository (Utrecht University)

Drug Addicts’ Decision Making Deficits: Behavioral Performance, Underlying Reasons and Interventions

刘, 洋. (2014) · Advances in Psychology · doi:10.12677/ap.2014.46110

Study of the interaction between 3,4 methylenedioximethamphetamine and the endocannabinoid system

Touriño, C. (2009) · Repositori digital de la UPF (Universitat Pompeu Fabra)

Le neuroscienze e la libertà del volere

Panerai, A. E. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/2240-9599/4172

Functional neuroanatomy of the evaluation of motivational significance : an orbitofrontal perspective

Diekhof, E. K. (2007) · doi:10.22028/d291-20865

Adolescent risk taking, dopamine signaling, and cocaine self-administration: a vicious cycle

Mitchell, M. R., Weiss, V. G., Morgan, D., Bizon, J. L., & Setlow, B. (2013) · F1000Research · doi:10.7490/f1000research.1093176.1

The role of the orbitofrontal cortex in reward related behavior in addiction and alcoholism in particular

Steketee, R. M. E. (2009) · Utrecht University Repository (Utrecht University)

Executive function

Logue, S. F., & Gould, T. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139541022.027 · Cited by 1

E pluribus unum? A new take on addiction by Redish et al.

Stalnaker, T. A., & Schoenbaum, G. M. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x08004950

Psychological Mechanisms of the Tendency of Super-quick Decay for Delayed Heroin Reinforcement in Heroin Abstainers

ZHANG, F., Shui, R., Yan-Yan, Z. H. O. U., LIANG, J.-Y., & Shen, M. (2009) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2009.00763

Neurobiologische Grundlagen des Wahlverhaltens bei Abhängigkeitserkrankungen

Bleich, S., & Heberlein, A. (2013) · Die Psychiatrie · doi:10.1055/s-0038-1670891

Intrapersonal Externalities: When Decisions Help or Hinder your Future Self

Stillwell, D. J. (2013) · Nottingham ePrints (University of Nottingham)

10 and Exploring the persuasive effects and neural activities of message framing on a home-based program for children with disabilities Competitive session EXPLORING THE PERSUASIVE EFFECTS AND NEURAL ACTIVITIES OF MESSAGE FRAMING ON A HOME-BASED PROGRAM FOR CHILDREN WITH DISABILITIES

Chen, C.-P., Yang, D.-J., & Wang, C.-C. (2014)

Neural Correlates of Moral Decision-Making in Neural Correlates of Moral Decision-Making in Psychopaths

Psychiatrie, F., & Rupprecht, R. (2011)

D2 Dopamine Receptor Mediation of Risky Decision-making

Simon, N. W. (2011) · OakTrust (Texas A&M University Libraries)

Drug Addicts' Decision Making Deficits: Behavioral Performance, Underlying Reasons and Interventions

Liu, Y., Song, H., Kou, J., & Zou, Z. (2014)

Addiction and Responsibility

Hyman, S. E. (2013) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195389784.003.0008

Targeting the trace amine-associated receptor 1 in psychomotor stimulant addiction.

Pei, Y. (2016) · UC Research Repository (University of Canterbury) · doi:10.26021/8251

Functional Reorganization of Reward- and Habit-Related Brain Networks in Addiction

Yalachkov, Y., Kaiser, J., & Naumer, M. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00019-0

A 1H-MRS and Neurocognitive Analysis of Psychotic Symptoms in Stimulant Dependence

Lakusta, B. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3q04w

「人となり」における大脳内側面・底面（眼窩面）の役割

船山, 道. (2017) · 神経心理学 · doi:10.20584/neuropsychology.17013

Opioid and stimulant use among a sample of corrections-involved drug users : seeking an understanding of high-risk drug decisions within a system of constraint.

Smith, K. E. (2019) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/3259

Foreword

Compton, W. M., & Blanco, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.001

Novel Psychoactive Substances: A New Challenge for Prevention and Treatment

Kapitány‐Fövény, M., Corazza, O., Marrinan, S., & Demetrovics, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.032

Human Laboratory Paradigms in Addictions Research

Morris, V. L., Arshad, F., Balodis, I. M., Reed, D. D., MacKillop, J. M., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.010

Anhedonia in Addictive Behaviors

Dyer, W. G., Leventhal, A. M., Goldenson, N. I., & Bello, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.039

American Legal Issues in Addiction Treatment and Research

Willick, D. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.041

The Physical and Social Environments as Determinants of Health: Implications for Substance and Behavioral Addictions

Strack, R. W., Orsini, M. M., Ewald, D. R., & Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.019

Faculty Opinions recommendation of Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.

Frank, M. J. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.3286956.2972054

Clinical and Research Methods in the Addictions

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.008

Levels of Analysis and Etiology

(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.014

Ongoing and Future Research Directions

(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.030

Frontal Cortex

Williams, M. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-68308-5_4

Preface

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.002

Impaired Physicians

Srivastava, A. B., & Gold, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.033

References

(2013) · CRC Press eBooks · doi:10.1201/b15462-35

Learning and memory

Crusio, W. E., Sluyter, F., Gerlai, R. T., & Pietropaolo, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139541022.026

Index

Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.042

Dysfunction of the motivational brain

Xu, P. (2022) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.219070985

Enhanced fear limits behavioral flexibility in a mouse model of autism spectrum disorderPreprint

Yun, M., Kim, E., & Jung, M. W. (2022) · Research Square · doi:10.21203/rs.3.rs-1730791/v1

A függőséggel terhelt test valósága, élményvilága és jelentésváltozatai

Marjai, K. (2023) · Máltai Tanulmányok · doi:10.56699/mt.2023.1.8

Neurobiologie

Walter, M., & Schmidt, A. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21074-7.00003-4

Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networksPreprint

Kim, C. M., Chow, C. C., & Averbeck, B. B. (2024) · eLife · doi:10.7554/elife.103660.1

Effects of acute stress and gender on decision-making

Wemm, S. (2014) · doi:10.54014/jd4x-zsgp

Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networksPreprint

Kim, C. M., Chow, C. C., & Averbeck, B. B. (2025) · eLife · doi:10.7554/elife.103660.2

Effects of COMT Suppression in a Randomized Trial on the Neural Correlates of Inhibitory Processing Among People With Alcohol Use Disorder

Winters, D. E., & Schacht, J. P. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.06.003

Value-based decision-making

Mochizuki, Y., Aggarwal, M., Harasawa, N., & Chen, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26629-4.00124-6

Additional file 1 of Enhanced fear limits behavioral flexibility in Shank2-deficient mice

Yun, M., Kim, E., & Jung, M. W. (2022) · Figshare · doi:10.6084/m9.figshare.21268985

The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in MicePreprint

Lichtman, D., Bergmann, E., Nicholas, J., Gerraty, R. T., & Kahn, I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700312

Right orbitofrontal cortex rTMS targets anxiety, not depressive, symptoms in first-episode schizophrenia

Yang, Y., Hu, Q., Jiao, X., Wei, Y., Cui, H., Tang, X., Xu, L., Tang, Y., Liu, H., Gao, J., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121300

Task-based functional connectivity in internet gaming disorder: A systematic review

Stevenson, J., Harding, R., Ofori, S., Wall, M. B., & Das, R. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111637

Alimentation durant l'adolescence : facteurs de troubles comportementaux et neurobiologiques à l'âge adulte : modèle animal chez le rat

Gueye, A. B. (2010) · theses.fr (ABES) · doi:10.70675/348ce609z5924z4ab5z9f76z80c1ef13a725

Addiction(s) à l'alcool et/ou au tabac et déficits émotionnels chez des sujets âgés institutionnalisés ou vivant à domicile

Boulon, L. (2017) · theses.fr (ABES) · doi:10.70675/ec543499zce4fz429dz83d0zfdba86c5991c

Processus émotionnels et cognitifs guidant la prise de décision : étude d'enfants, d'adolescents et d'adultes typiques ou ayant un trouble du spectre de l'autisme

Gosling, C. J. (2018) · theses.fr (ABES) · doi:10.70675/5b8b4fdfz5d79z4b07z963azb45df2c26bd0

Cortex préfrontal et flexibilité comportementale : implication de la noradrénaline

Cerpa, J.-C. (2019) · theses.fr (ABES) · doi:10.70675/d4f665b9z3943z4c88z9b4bzbf11cd7cf8d1

Contribution d'une activité neuronale pacemaker dans l'expression et l'adaptation d'un comportement motivé chez l'aplysie

Puygrenier, L. (2019) · theses.fr (ABES) · doi:10.70675/c632ab07z5b2ez4f68zaa26z9533043f65ab

The role of chromatin remodelers in dopaminoceptive neurons

Zayed, A. (2019) · theses.fr (ABES) · doi:10.70675/f1d09c9dz29c5z44e4zae26z358715db672e

A closed loop framework of decision-making and learning in primate prefrontal circuits.

Nallapu, B. T. (2019) · theses.fr (ABES) · doi:10.70675/ec68f782z2b3ez44f3zb24fzeafa25ff668c · Cited by 1

Rang social, système dopaminergique et réponse au stress

Battivelli, D. (2019) · theses.fr (ABES) · doi:10.70675/b11d29f4z1bf3z4003z81f9z8c69988b277b

Analyse comportementale et électrophysiologique de l'impact de la fatigue cognitive sur les capacités d'adaptation

Salomone, M. (2021) · theses.fr (ABES) · doi:10.70675/774f06d3z0a80z4d86zb041z7fd7802f1965

The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in MicePreprint

Lichtman, D., Bergmann, E., Nicholas, J., Gerraty, R. T., & Kahn, I. (2026) · eLife · doi:10.7554/elife.110415.1

The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in MicePreprint

Lichtman, D., Bergmann, E., Nicholas, J., Gerraty, R. T., & Kahn, I. (2026) · eLife · doi:10.7554/elife.110415

Skill Practice Is Associated With Functional Reorganization of the Brain–Joint Network

Bizen, H., Kimura, D., Yamada, K., Tomiyama, N., & Mizuno‐Matsumoto, Y. (2026) · Journal of Motor Learning and Development · doi:10.1123/jmld.2025-0090

mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice

Akhoond-Ali, Z., Ghazavi, H., Hosseini, M., Fereidoni, M., Polgardani, L., Nakhaei, A., & Vafaee, F. (2026) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_197_25

Neurocognitive risk and protective factors in addictive disorders

Smith, D. G. (2014) · Apollo (University of Cambridge) · doi:10.17863/cam.16469

Role of Cholinergic Projections to the Orbitofrontal Cortex in Probability Discounting in a Rat Model

Albert-Stone, E. (2015) · W&M Publish (College of William & Mary)

The Orbital Prefrontal Cortex and Drug Addiction in Laboratory Animals and Humans

Everitt, B. J., Hutcheson, D. M., Ersche, K. D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.022 · Cited by 143

Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging

London, E. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.334 · Cited by 360

Abnormal associative encoding in orbitofrontal neurons in cocaine‐experienced rats during decision‐making

Stalnaker, T. A., Roesch, M. R., Franz, T. M., Burke, K. A., & Schoenbaum, G. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05128.x · Cited by 83

Risky Business: Emotion, Decision-Making, and Addiction

Bechara, A. (2003) · Journal of Gambling Studies · doi:10.1023/a:1021223113233 · Cited by 495

Substance use disorders and the orbitofrontal cortex: Systematic review of behavioural decision-making and neuroimaging studies

Dom, G., Sabbe, B., Hulstijn, W., & van Den Brink, W. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.3.209 · Cited by 231