Cited by 499Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral Economics

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Orbitofrontal cortex, decision-making and drug addiction

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Schoenbaum, Geoffrey, Roesch, Matthew R., Stalnaker, Thomas A.·2006·Trends in Neurosciences

DOI 10.1016/j.tins.2005.12.006PMC PMC2430629

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Abstract

The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.

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Authors: Schoenbaum, G., Roesch, M. R., & Stalnaker, T. A.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Schoenbaum, Geoffrey
ORCID: Schoenbaum, Geoffrey
Roesch, Matthew R.
Stalnaker, Thomas A.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2006-02
Volume: 29
Issue: 2
Pages: 116-124
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2005.12.006
PMC: PMC2430629
OpenAlex: W2099221443
Cited by: 499
References: 95
Citations by year: 2026: 11 · 2025: 18 · 2024: 18 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 60 · 2019: 28 · 2018: 19 · 2017: 24 · 2016: 22 · 2015: 16 · 2014: 18 · 2013: 27 · 2012: 21
FWCI: 2.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA015718)
National Institute on Deafness and Other Communication Disorders (T32 DC 00054, T32DC000054)
National Institute of Neurological Disorders and Stroke (T32 NS07375, T32NS007375)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: orbitofrontal cortex, decision-making, drug addiction, prefrontal cortex, executive function, associative learning, basolateral amygdala, nucleus accumbens, outcome value, maladaptive decision-making
MeSH terms: Animals, Decision Making, Humans, Neural Pathways, Orbit, Prefrontal Cortex, Substance-Related Disorders

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Orbitofrontal cortex, decision-making and drug addiction

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