The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Abstract
There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse.
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“Animal studies have shown that dopamine is crucial for communication between the accumbens, amygdala, and prefrontal cortex and that signaling between these regions relies upon the fine balance between excitatory and inhibitory dopamine transmission (Floresco & Tse 2007; Grace et al. 2007; Jackson et al. 2001).”
From The Adolescent Brain (2008) · cites this paper as Grace et al. 2007
In the citing paper
“increased firing of VTA dopamine neurons has long been documented in response to rewards as well as to aversive stimuli, and it has been suggested that they increase salience for both types of stimuli24, 73–76”
From Neurobiology of resilience (2012) · cites this paper as [75]
In the citing paper
“The cholinergic system exerts a profound effect on DAergic activity as ACh released in the VTA promotes the switch between tonic and phasic activity in DAergic neurons that signals reward and salience [38, 39].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [39]
In the citing paper
“DA neurons in the midbrain project to medium spiny neurons in the NAcc as well as pyramidal neurons in the PFC, thereby modulating the firing rates of these neurons and establishing a strong reciprocal relationship between striatum and PFC (Grace, Floresco et al. 2007).”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Grace, Floresco et al. 2007
In the citing paper
“DA levels are modulated by two dissociable processes of DA discharge that interact, (1) a constant background tonicity regulated by baseline firing of DA neurons and glutamatergic afferents from cortical to striatal regions, and (2) a burst firing high-amplitude phasic release (Grace, Floresco et al. 2007).”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Grace, Floresco et al. 2007
Citations
Cites
Predictive reward signal of dopamine neurons
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
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The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Self-citationGrace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Self-citationNeuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346
Self-citationDOPAMINERGIC NEURONS: EFFECT OF ANTIPSYCHOTIC DRUGS AND AMPHETAMINE ON SINGLE CELL ACTIVITY
Bunney, B. S., Walters, J. R., Roth, R. H., & Aghajanian, G. K. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29539-8 · Cited by 1,283
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
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Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36
Pharmacotherapy for Neuropsychiatric Symptoms in Frontotemporal Dementia
Le, C., & Finger, E. (2021) · CNS Drugs · doi:10.1007/s40263-021-00854-5 · Cited by 26
Bailer, U. F., Price, J. C., Meltzer, C. C., Wagner, A., Mathis, C. A., Gamst, A., & Kaye, W. H. (2017) · International Journal of Eating Disorders · doi:10.1002/eat.22638 · Cited by 33
Orzeł-Gryglewska, J., Matulewicz, P., & Jurkowlaniec, E. (2015) · Synapse · doi:10.1002/syn.21843 · Cited by 31
Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat
Yetnikoff, L., Reichard, R. A., Schwartz, Z. M., Parsely, K. P., & Zahm, D. S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23459 · Cited by 30
McNair, L. F., & Kohlmeier, K. A. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000439 · Cited by 22
Genetic variation in GABRA 2 moderates peer influence on externalizing behavior in adolescents
Villafuerte, S., Trucco, E. M., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2014) · Brain and Behavior · doi:10.1002/brb3.291 · Cited by 22
Neural correlates of working memory training: An fMRI meta-analysis
Zhang, Y., Fu, J., & Zhao, X. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120885 · Cited by 20
Moreines, J. L., Owrutsky, Z. L., Gagnon, K. G., & Grace, A. A. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0039-9 · Cited by 17
Self-citationMidbrain fMRI: Applications, Limitations and Challenges
Düzel, E., Guitart-Masip, M., Maass, A., Hämmerer, D., Betts, M. J., Speck, O., Weiskopf, N., & Kanowski, M. (2015) · Biological Magnetic Resonance · doi:10.1007/978-1-4899-7591-1_20 · Cited by 16
Metadata
- Authors
- Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J.
- Affiliations
- University of Pittsburgh (US)
- University of British Columbia (CA)
- McGill University (CA)
- Corresponding author
- Grace, Anthony A.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 30
- Issue
- 5
- Pages
- 220-227
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2058578514
- Cited by
- 1,034
- References
- 62
- Citations by year
- 2026: 28 · 2025: 25 · 2024: 37 · 2023: 37 · 2022: 38 · 2021: 49 · 2020: 43 · 2019: 42 · 2018: 59 · 2017: 50 · 2016: 68 · 2015: 80 · 2014: 74 · 2013: 69 · 2012: 70
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopaminergic neurons, dopaminergic system, nucleus accumbens, ventral hippocampus, amygdala, prefrontal cortex, goal-directed behavior, motivated behavior, schizophrenia, drug abuse, mental illness
- MeSH terms
- Animals, Behavior, Behavior, Animal, Brain, Dopamine, Humans, Neural Pathways, Neurons, Reward, Schizophrenia, Substance-Related Disorders
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