Cited by 31Neural dynamics and brain functionSleep and Wakefulness ResearchMemory and Neural Mechanisms

Brainstem system of hippocampal theta induction: The role of the ventral tegmental area: VTA and Theta Rhythm

Orzeł-Gryglewska, Jolanta, Matulewicz, Paweł, Jurkowlaniec, Edyta·2015·Synapse

Abstract

This article summarizes the results of studies concerning the influence of the ventral tegmental area (VTA) on the hippocampal theta rhythm. Temporary VTA inactivation resulted in transient loss of the hippocampal theta. Permanent destruction of the VTA caused a long-lasting depression of the power of the theta and it also had some influence on the frequency of the rhythm. Activation of glutamate (GLU) receptors or decrease of GABAergic tonus in the VTA led to enhancement of dopamine release and increased hippocampal theta power. High time and frequency cross-correlation was detected for the theta band between the VTA and hippocampus during paradoxical sleep and active waking. Thus, the VTA may belong to the broad network involved in theta rhythm regulation. This article also presents a model of brainstem-VTA-hippocampal interactions in the induction of the hippocampal theta rhythm. The projections from the VTA which enhance theta rhythm are incorporated into the main theta generation pathway, in which the septum acts as the central node. The neuronal activity that may be responsible for the ability of the VTA to regulate theta probably derives from the structures associated with rapid eye movement (sleep) (REM) sleep or with sensorimotor activity (i.e., mainly from the pedunculopontine and laterodorsal tegmental nuclei and also from the raphe).

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Crossref · 10.1002/syn.21843

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Authors
Orzeł-Gryglewska, J., Matulewicz, P., & Jurkowlaniec, E.
Affiliations
University of Gdańsk (PL)
Corresponding author
Orzeł-Gryglewska, Jolanta
Venue
Synapse
Publisher
Wiley
Published
2015-08-19
Volume
69
Issue
11
Pages
553-575
ISSN
0887-4476 (ISSN-L)
OpenAlex
W1833543883
Cited by
31
References
275
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Locations
  • Synapse (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampal theta rhythm, ventral tegmental area, brainstem, dopamine release, glutamate receptors, GABAergic inhibition, septum, REM sleep, pedunculopontine nucleus, laterodorsal tegmental nucleus, raphe nuclei
MeSH terms
Animals, Hippocampus, Neural Pathways, Neurons, Theta Rhythm, Ventral Tegmental Area

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