Genetic variation in GABRA 2 moderates peer influence on externalizing behavior in adolescents
Open accessAbstract
Background: Genetic predisposition and environmental influences are both important factors in the development of problematic behavior leading to substance use in adolescence. Involvement with delinquent peers also strongly predicts adolescent externalizing behavior. Several lines of evidence support a role of GABRA 2 on externalizing behavior related to disinhibition. However, whether this genetic association is influenced by the environment such as peer behavior remains unknown. Methods: We examined the moderating role of GABRA 2 genetic variation on the socialization model of delinquent peer affiliation (at ages 12–14 years) on externalizing behavior (at ages 15–17 years) in the Michigan Longitudinal Study (MLS) adolescent sample. The sample consisted of 244 adolescents (75 females and 152 with at least one parent with a DSM‐IV lifetime alcohol dependence/abuse diagnosis). Peer delinquent activity reported by the participant and teacher‐reported adolescent externalizing behavior (Teacher Report Form (TRF) were assessed. Results: No main effect of the GABRA 2 SNP rs279826, which tags a large haplotype, on externalizing behavior was observed. However, there was a statistically reliable GABRA 2 × peer delinquency interaction. The effect of peer delinquent involvement on externalizing scores and the rule breaking subscale is significantly stronger for those with the GG genotype compared to A‐carriers, whereas there was no effect of genotype on externalizing in the absence of peer delinquent involvement. No interaction was observed for the aggression subscale. Conclusion: Our results suggest that the genetic effect of GABRA 2 on externalizing behavior, more specifically on rule breaking is, at least in part, due to its effect on susceptibility to environmental exposure (i.e., peer delinquency).
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There was no significant gene-environment interaction on aggression.
“NS GxE on aggression”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Villafuerte [160]
There was no significant main effect of GABRA2 rs279826 on aggression.
“NS main effect”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Villafuerte [160]
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- Authors
- Villafuerte, S., Trucco, E. M., Heitzeg, M. M., Burmeister, M., & Zucker, R. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Villafuerte, Sandra
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2014-10-13
- Volume
- 4
- Issue
- 6
- Pages
- 833-840
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC4212110
- OpenAlex
- W1981340865
- Cited by
- 22
- References
- 49
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R37 AA07065, R03 AA01957601)
- National Institute on Drug Abuse (R01 DA02726, R01 DA17732)
- National Center for Advancing Translational Sciences (2UL1TR000433)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- GABRA2, genetic variation, peer delinquency, externalizing problems, adolescents, gene-environment interaction, rule violations, aggression, disinhibition
- MeSH terms
- Adolescent, Adolescent Behavior, Aggression, Child, Female, Haplotypes, Humans, Juvenile Delinquency, Longitudinal Studies, Male, Psychiatric Status Rating Scales, Receptors, GABA-A, Linkage Disequilibrium, Linear Models, Attention Deficit and Disruptive Behavior Disorders, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genotyping Techniques
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