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The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Open accessAbstract
Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms. Additionally, it remains unclear whether structural plasticity and its synaptic concomitants drive addictive behaviors or whether they reflect homeostatic compensations to the drug not related to addiction per se. Here, we discuss recent paradoxical data, which either support or oppose the hypothesis that drug-induced changes in dendritic spines drive addictive behavior. We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies.
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“According to this model there are distinguishable associative and nonassociative components of addiction, and the molecular mechanisms and neural substrates underlying these processes may overlap with those involved in canonical forms of memory (Anagnostaras and Robinson, 1996; Anagnostaras et al., 2002; Russo et al., 2010).”
From Proteasome phosphorylation regulates cocaine-induced sensitization (2018) · cites this paper as Russo et al., 2010
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Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationStructural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,382
Self-citationChanging subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,377
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,130
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108
Self-citationHarris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 1,036
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Ballesteros‐Yáñez, I. (2021) · Ediciones de la Universidad de Castilla-La Mancha eBooks · doi:10.18239/atenea_2021.23.02
Epigenetic mechanisms of drug addiction vulnerability
Milian, A. A., Bendersky, C. J., & Walker, D. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00008-8
Introduction to DrLoop - A Software Module for Assessment of Control Loop Performance.
Lai, C.-W., Wang, T., Lee, M.-W., You, H.-S., & Jeng, J. (2003)
Aston‐Jones, G., & Mahler, S. V. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13355964.14762056
Whole-Brain Map of Top-down afferent Inputs to Nucleus Accumbens of the MousePreprint
Xu, T., Wu, J., Chen, Z., & Li, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.02.478577
Fulton, B. S. (2014) · Wiley eBooks · doi:10.1002/9781118943670.refs
Faculty Opinions recommendation of One is not enough: understanding and modeling polysubstance use.
Grunberg, N. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738149771.793576347
Faculty Opinions recommendation of Nucleus accumbens modulation in reward and aversion.
Wolf, M. E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734917622.793558354
Russo, S. J., & Han, M. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731077746.793537883
Self-citationThe Ethics of Neuroenhancement
Wagner, N., Robinson, J., & Wiebking, C. (2018) · IGI Global eBooks · doi:10.4018/978-1-5225-7666-2.ch005
Trivedi, M. S. (2013) · Digital Repository Service (Northeastern University) · doi:10.17760/d20198517
Cellular and Molecular Mechanisms of Addiction
Reissner, K. J., & Kalivas, P. W. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0046
Cellular Plasticity in Cocaine Addiction
Lopizzo, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00119-5
Kaszyńska, A. A. (2022) · Studia Humanistyczne/Studia Humanistyczne AGH · doi:10.7494/human.2022.21.1.23
Modeling the drug withdrawal syndrome in zebrafish (Danio rerio)
Zabegalov, K. N., Galstyan, D. S., Kolesnikova, T. O., Kositsyn, Y. M., Gubaidullina, M. A., Maslov, G. O., Demin, K. A., Khatsko, S. L., & Kalueff, A. V. (2022) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf202185-191
Jang, C., Kim, Y., Kim, K., Lee, Y., Ko, Y., Lee, B., Hur, K., Kim, S., & Lee, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2111114/v1
An important new chapter in Neuroscience
Tuckwell, H. C. (2023) · Journal of Multiscale Neuroscience · doi:10.56280/1579486051
Wang, T., Lee, S., Cheng, J.-L., & Chen, K.-C. (2023) · International Conference on Computational Biology and Bioinformatics (ICCBB) · doi:10.1145/3638569.3638575
Saviola, F., Tambalo, S., Beghini, L., Ferrari, A., Cassone, B., Ville, D. V. D., & Jovicich, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.30.621153
Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampusPreprint
Eagle, A. L., Doyle, M. A., Sugimoto, C., Dykstra, M. M., Kuhn, H. M., Murray, B. S., Bastle, R. M., He, J., Maze, I. S., Mazei‐Robison, M. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.06.621895
Cellular and Molecular Mechanisms of Substance Use Disorders
Reissner, K. J. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0048
Evans, C. J., Jentsch, D., Kieffer, B. L., Maldonado, R. J., & Cahill, C. M. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0047
Berry, E. A., Huhulea, E. N., Ishibashi, M., McGregor, R., Siegel, J. M., & Leonard, C. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.20.644444
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Dewani, A. P., Mohale, D., Tripathi, A. S., & Sheikh, N. W. A. (2025) · doi:10.1002/9781394242474.ch3
Dopamine modulation of synaptic transmission in drug addiction
Reva, M., & Lüscher, C. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00037-2
Nonhuman research methods and procedures for studying operant demand
Gipson, C. D., Corley, C. L., Craig, A. J., Koffarnus, M. N., & Beckmann, J. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95745-8.00014-6
ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis
Zhao, Y., Li, S., Jiang, L., Zhao, Y., Kuang, W., Wei, Q., Zhou, Y., Han, S., Wang, L., Li, H., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1677343
Finegersh, A. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Johnson, C. S., Chapp, A. D., Lind, E. B., Thomas, M. J., & Mermelstein, P. (2024) · Figshare · doi:10.6084/m9.figshare.26651943
Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880435
Self-citationCole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880432
Self-citationJohnson, C. S., Chapp, A. D., Lind, E. B., Thomas, M. J., & Mermelstein, P. (2024) · Figshare · doi:10.6084/m9.figshare.26651934
Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880426
Self-citationCole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880429
Self-citationJohnson, C. S., Chapp, A. D., Lind, E. B., Thomas, M. J., & Mermelstein, P. (2024) · Figshare · doi:10.6084/m9.figshare.26651940
Taborda-Bejarano, J. P., Meyerink, M. E., Crans, D. C., Ramchandran, R., & García‐Keller, C. (2025) · Cells · doi:10.3390/cells15010032 · Cited by 1
Zanderigo, F., Laurell, G. L., Doubrovin, M., Molotkov, A., Alì, A., Arevalo, R., Sai, K. K. S., Mann, J. J., & Mintz, A. (2026) · Journal of Nuclear Medicine · doi:10.2967/jnumed.125.271335
Qinghua, H., & Zhaosong, W. (2026) · Research Square · doi:10.21203/rs.3.rs-6655884/v1
Borjkhani, M., Borjkhani, H., & Sharif, M. A. (2026) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2026.1753417
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Boulle, F. (2013) · theses.fr (ABES) · doi:10.70675/7796cc83z9f91z48c6zadb1zb6a90897b5d5
Regulation of the protein synthesis machinery in the striatum
Biever, A. (2016) · theses.fr (ABES) · doi:10.70675/d51e3b2cz4ba2z4930z8686z2d89c7f3949d
Mansouri-Guilani, N. (2017) · theses.fr (ABES) · doi:10.70675/99ced3b5zeac6z4eb2z8e6cz01bcad7cf2d9
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Mongrédien, R. (2018) · theses.fr (ABES) · doi:10.70675/926d644czef3bz4ce3z9fd7z6080a7628079
Nogueira, D. D. S. (2019) · theses.fr (ABES) · doi:10.70675/d429d5dbz5001z4e60z9622z4f636e667f17
Hossain, W. A., & Butler, M. G. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1763510
Bahí, A., & Dreyer, J. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07167-9
Albert, O. M. (2026) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2026.101958
Metadata
- Authors
- Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Stanford Medicine (US)
- Corresponding author
- Russo, Scott J.
- ORCID
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 33
- Issue
- 6
- Pages
- 267-276
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2891948
- OpenAlex
- W2084967673
- Cited by
- 654
- References
- 97
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 27 · 2023: 25 · 2022: 31 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 53 · 2017: 57 · 2016: 48 · 2015: 45 · 2014: 49 · 2013: 49 · 2012: 56
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (F32DA019727, T32DA007290, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- addiction, nucleus accumbens, synaptic plasticity, structural plasticity, dendritic spines, medium spiny neurons, limbic system, homeostatic compensation, ultrastructure, electrophysiology, behavioral plasticity
- MeSH terms
- Animals, Models, Biological, Neuronal Plasticity, Neurons, Nucleus Accumbens, Illicit Drugs, Synapses, Signal Transduction, Substance-Related Disorders, Dendritic Spines
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