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The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

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Russo, Scott J., Dietz, David M., Dumitriu, Dani, Morrison, John H., Malenka, Robert C., Nestler, Eric J.·2010·Trends in Neurosciences

DOI 10.1016/j.tins.2010.02.002PMC PMC2891948

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Abstract

Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms. Additionally, it remains unclear whether structural plasticity and its synaptic concomitants drive addictive behaviors or whether they reflect homeostatic compensations to the drug not related to addiction per se. Here, we discuss recent paradoxical data, which either support or oppose the hypothesis that drug-induced changes in dendritic spines drive addictive behavior. We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies.

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Authors: Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Stanford Medicine (US)
Corresponding author: Russo, Scott J.
ORCID: Russo, Scott J.
Dietz, David M.
Dumitriu, Dani
Morrison, John H.
Malenka, Robert C.
Nestler, Eric J.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2010-06
Volume: 33
Issue: 6
Pages: 267-276
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2010.02.002
PMC: PMC2891948
OpenAlex: W2084967673
Cited by: 654
References: 97
Citations by year: 2026: 10 · 2025: 25 · 2024: 27 · 2023: 25 · 2022: 31 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 53 · 2017: 57 · 2016: 48 · 2015: 45 · 2014: 49 · 2013: 49 · 2012: 56
FWCI: 4.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (F32DA019727, T32DA007290, R01DA014133)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: addiction, nucleus accumbens, synaptic plasticity, structural plasticity, dendritic spines, medium spiny neurons, limbic system, homeostatic compensation, ultrastructure, electrophysiology, behavioral plasticity
MeSH terms: Animals, Models, Biological, Neuronal Plasticity, Neurons, Nucleus Accumbens, Illicit Drugs, Synapses, Signal Transduction, Substance-Related Disorders, Dendritic Spines

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The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

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