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More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses

Krieglstein, Kerstin, Zheng, Fang, Unsicker, Klaus, Alzheimer, Christian·2011·Trends in Neurosciences
DOI 10.1016/j.tins.2011.06.002
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Abstract

It is becoming increasingly clear that members of the transforming growth factor-β (TGF-β) family have roles in the central nervous system that extend beyond their well-established roles as neurotrophic and neuroprotective factors. Recent findings have indicated that the TGF-β signaling pathways are involved in the modulation of both excitatory and inhibitory synaptic transmission in the adult mammalian brain. In this review, we discuss how TGF-β, bone morphogenetic protein and activin signaling at central synapses modulate synaptic plasticity, cognition and affective behavior. We also discuss the implications of these findings for the molecular understanding and potential treatment of neuropsychiatric diseases, such as anxiety, depression and other neurological disorders.

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Metadata

Authors
Krieglstein, K., Zheng, F., Unsicker, K., & Alzheimer, C.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2011-08
Volume
34
Issue
8
Pages
421-429
ISSN
0166-2236
DOI
10.1016/j.tins.2011.06.002
Cited by
127
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses. https://app.cochat.ai/papers/10.1016/j.tins.2011.06.002
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Krieglstein, K., Zheng, F., Unsicker, K., & Alzheimer, C. (2011). More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses. Trends in Neurosciences. https://doi.org/10.1016/j.tins.2011.06.002