Cited by 436Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismAlzheimer's disease research and treatments

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The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

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Martini-Stoica, Heidi, Xu, Yin, Ballabio, Andrea, Zheng, Hui·2016·Trends in Neurosciences

DOI 10.1016/j.tins.2016.02.002PMC PMC4928589

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Abstract

The autophagy-lysosomal pathway (ALP) is involved in the degradation of long-lived proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and prion disease. Decades of research have therefore focused on enhancing the ALP in neurodegenerative diseases. More recently, transcription factor EB (TFEB), a major regulator of autophagy and lysosomal biogenesis, has emerged as a leading factor in addressing disease pathology. We review the regulation of the ALP and TFEB and their impact on neurodegenerative diseases. We also offer our perspective on the complex role of autophagy and TFEB in disease pathogenesis and its therapeutic implications through the examination of prion disease.

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Authors: Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Zheng, Hui
ORCID: Xu, Yin
Ballabio, Andrea
Zheng, Hui
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2016-04
Volume: 39
Issue: 4
Pages: 221-234
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2016.02.002
PMC: PMC4928589
OpenAlex: W2293027573
Cited by: 436
References: 127
Citations by year: 2026: 38 · 2025: 41 · 2024: 46 · 2023: 65 · 2022: 48 · 2021: 53 · 2020: 43 · 2019: 34 · 2018: 27 · 2017: 31 · 2016: 10
FWCI: 4.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (RF1AG020670, F30AG050412, R01AG020670)
National Institute of Neurological Disorders and Stroke (R01NS076117, RF1NS093652, R01NS078072, R01NS093652)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: autophagy-lysosome pathway, TFEB, neurodegenerative diseases, lysosomal biogenesis, protein aggregation, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, autophagy regulation, therapeutic target
MeSH terms: Animals, Autophagy, Brain, Humans, Lysosomes, Nerve Degeneration, Neurodegenerative Diseases, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

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