The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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TFEB Links Autophagy to Lysosomal Biogenesis

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The Role of Atg Proteins in Autophagosome Formation

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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A Gene Network Regulating Lysosomal Biogenesis and Function

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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Transmission and spreading of tauopathy in transgenic mouse brain

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Selective autophagy mediated by autophagic adapter proteins

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Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

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Autophagosomes form at ER–mitochondria contact sites

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

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Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

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Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

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The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Settembre, C., De Cegli, R., Mansueto, G., Saha, P. K., Vetrini, F., Visvikis, O., Huynh, T., Carissimo, A., Palmer, D., Jürgen Klisch, T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2718 · Cited by 1,022

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

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Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

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Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

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Microautophagy of Cytosolic Proteins by Late Endosomes

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Plasma membrane contributes to the formation of pre-autophagosomal structures

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Amino acid signalling upstream of mTOR

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Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease

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Compromised autophagy and neurodegenerative diseases

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

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In Vitro Generation of Infectious Scrapie Prions

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

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FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

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Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

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The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

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microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

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Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

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FOXO transcription factors

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Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

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Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy

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Regulation of TFEB and V‐ATPases by mTORC1

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

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PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits

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Huntingtin functions as a scaffold for selective macroautophagy

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N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

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The structure of Atg4B–LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

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Mitochondria removal by autophagy

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Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions

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Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset

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mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

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Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

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Lysosomotropic Agents and Cysteine Protease Inhibitors Inhibit Scrapie-Associated Prion Protein Accumulation

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CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

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Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

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MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

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Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

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Autophagy induction by trehalose counter-acts cellular prion-infection

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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

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The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

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Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

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A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

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