Circuit organization of the rodent medial prefrontal cortex

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Inhibitory specificity from a connectomic census of mouse visual cortex

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The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands

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Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain

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Cell-type-specific inhibitory circuitry from a connectomic census of mouse visual cortexPreprint

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Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice

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Brain-Wide Projections and Differential Encoding of Prefrontal Neuronal Classes Underlying Learned and Innate Threat Avoidance

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Single-neuron analysis of dendrites and axons reveals the network organization in mouse prefrontal cortex

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Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice

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Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions

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Learning how network structure shapes decision-making for bio-inspired computing

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Top-down control of flight by a non-canonical cortico-amygdala pathway

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Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia

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Circuit mechanism for suppression of frontal cortical ignition during NREM sleep

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Functional connectivity of amygdala subnuclei in PTSD: a narrative review

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Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility

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Deconstructing the neural circuit underlying social hierarchy in mice

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Age- and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and neurodevelopmental disorders

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Regulation of the E/I-balance by the neural matrisome

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Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

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Inflammatory processes in the prefrontal cortex induced by systemic immune challenge: Focusing on neurons

Mittli, D. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100703 · Cited by 32

Medial prefrontal cortex circuitry and social behaviour in autism

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Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models

Kupferschmidt, D. A., Cummings, K. A., Joffe, M. E., MacAskill, A. F., Malik, R., Sánchez-Bellot, C., Tejeda, H. A., & Yarur, H. E. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1136-22.2022 · Cited by 28

Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice

Botterill, J. J., Khlaifia, A., Appings, R., Wilkin, J., Violi, F., Premachandran, H., Cruz-Sanchez, A., Canella, A. E., Patel, A., Zaidi, S. D., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01795-5 · Cited by 30

Elevated dorsal medial prefrontal cortex to lateral habenula pathway activity mediates chronic stress-induced depressive and anxiety-like behaviors

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Top-down projections of the prefrontal cortex to the ventral tegmental area, laterodorsal tegmental nucleus, and median raphe nucleus

Souza, R., Bueno, D., Lima, L. B., Muchon, M. J., Gonçalves, L., Donato, J., Shammah‐Lagnado, S. J., & Metzger, M. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02538-2 · Cited by 30

Dopaminergic Modulation of Prefrontal Cortex Inhibition

Domenico, D. D., & Mapelli, L. (2023) · Biomedicines · doi:10.3390/biomedicines11051276 · Cited by 31

Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication

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Prefrontal and lateral entorhinal neurons co-dependently learn item–outcome rules

Jun, H., Lee, J. Y., Bleza, N. R., Ichii, A., Donohue, J. D., & Igarashi, K. M. (2024) · Nature · doi:10.1038/s41586-024-07868-1 · Cited by 26

Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex

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Chronic restraint stress induces depression-like behaviors and alterations in the afferent projections of medial prefrontal cortex from multiple brain regions in mice

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The medial prefrontal cortex as a proposed regulatory structure in the relationship between anxiety and perceived social support: a review

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Alpha-Synuclein Pre-Formed Fibrils Injected into Prefrontal Cortex Primarily Spread to Cortical and Subcortical Structures

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Auditory processing control by the medial prefrontal cortex: A review of the rodent functional organisation

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A Prelimbic Cortex-Thalamus Circuit Bidirectionally Regulates Innate and Stress-Induced Anxiety-Like Behavior

Zhang, S.-R., Wu, D., Luo, R., Wu, J., Chen, H., Li, Z.-M., Zhuang, J.-P., Hu, N.-Y., Li, X., Yang, J., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2103-23.2024 · Cited by 24

Transitions in dynamical regime and neural mode during perceptual decisions

Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A., Kopec, C. D., Elliott, V. A., DePasquale, B., & Brody, C. D. (2025) · Nature · doi:10.1038/s41586-025-09528-4 · Cited by 49

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

Jiang, Q., Shao, L.-X., Yao, S., Savalia, N. K., Gilbert, A. D., Davoudian, P. A., Nothnagel, J. D., Tian, G., Hung, J. T. S., Lai, H. M., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.009 · Cited by 27

Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress

Liu, W.-Z., Wang, C.-Y., Wang, Y., Cai, M.-T., Zhong, W.-X., Liu, T., Wang, Z.-H., Pan, H.-Q., Zhang, W.-H., & Pan, B.-X. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01050-2 · Cited by 21

ATLAS: a rationally designed anterograde transsynaptic tracer

Rivera, J. F., Huang, H., Weng, W., Sohn, H., Girasole, A. E., Li, S., Albanese, M. A., Qin, M., Tao, C., Klug, M. E., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02670-x · Cited by 20

Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice

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Dynorphin / kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner

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Cellular Substrate of Eligibility TracesPreprint

Caya-Bissonnette, L., Naud, R., & Béïque, J.-C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.29.547097 · Cited by 23

Expression and function of nicotinic acetylcholine receptors in specific neuronal populations: Focus on striatal and prefrontal circuits

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Transitions in dynamical regime and neural mode underlie perceptual decision-makingPreprint

Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A., Kopec, C. D., Elliott, V. A., DePasquale, B., & Brody, C. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.15.562427 · Cited by 19

Opioidergic activation of the descending pain inhibitory system underlies placebo analgesia

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The Gut Microbiota Metabolite Butyrate Modulates Acute Stress-Induced Ferroptosis in the Prefrontal Cortex via the Gut–Brain Axis

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Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex

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Maladaptive Neuroplasticity Under Stress: Insights into Neuronal and Synaptic Changes in the Prefrontal Cortex

Ren, B., Yuan, Q., Cha, S., Liu, S.-Y. M., Zhang, J., & Guo, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05152-5 · Cited by 21

Sex differences in glutamate transmission and plasticity in reward related regions

Kniffin, A. R., & Briand, L. A. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1455478 · Cited by 20

Cellular rules underlying psychedelic control of prefrontal pyramidal neuronsPreprint

Ekins, T. G., Brooks, I. A. W., Kailasa, S., Rybicki-Kler, C., Jedrasiak‐Cape, I., Donoho, E., Mashour, G. A., Rech, J. C., & Ahmed, O. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.20.563334 · Cited by 19

Multi-region coordination of evidence accumulation and decision commitment in the brainPreprint

Bondy, A., Charlton, J. A., Luo, T. Z., Kopec, C. D., Stagnaro, W. M., Venditto, S. J. C., Shi, K., Xie, E. Y., Beau, M., Lynch, L. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.21.609044 · Cited by 28

Adolescence alcohol exposure impairs fear extinction and alters medial prefrontal cortex plasticity

Lawson, K., Scarlata, M. J., Cho, W. C., Mangan, C., Petersen, D., Thompson, H. M., Ehnstrom, S., Mousley, A. L., Bezek, J. L., & Bergstrom, H. C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109048 · Cited by 16

The projection from dorsal medial prefrontal cortex to basolateral amygdala promotes behaviors of negative emotion in rats

Cai, Y.-Q., Ge, J., & Pan, Z.-Z. Z. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1331864 · Cited by 16

Anterior cingulate cortex and its projections to the ventral tegmental area regulate opioid withdrawal, the formation of opioid context associations and context-induced drug seeking

McKendrick, G., McDevitt, D. S., Shafeek, P., Cottrill, A. R., & Graziane, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.972658 · Cited by 17

Opioid modulation of prefrontal cortex cells and circuits

Cole, R. H., Moussawi, K., & Joffe, M. E. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109891 · Cited by 16

Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex

Li, J., Temizer, R., Chen, Y.-W., & Aoki, C. J. (2024) · Brain Structure and Function · doi:10.1007/s00429-023-02740-w · Cited by 13

Subregion preference in the long-range connectome of pyramidal neurons in the medial prefrontal cortex

Tudi, A., Yao, M., Tang, F., Zhou, J., Li, A., Gong, H., Jiang, T., & Li, X. (2024) · BMC Biology · doi:10.1186/s12915-024-01880-7 · Cited by 16

A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation

Gongwer, M. W., Qi, A., Enos, A. S., Mora, S. A. R., Solakoğlu, S. T., Ahmed, R. N., Klune, C. B., Shari, M., Kashay, A. Q., Williams, O. H., et al. (2026) · Cell · doi:10.1016/j.cell.2025.12.040 · Cited by 24

Mechanisms Linking Physical Activity With Mental Health in Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review

Liu, C., Liang, X., Yang, Y., Liu, R., Arbour‐Nicitopoulos, K. P., & Sit, C. H. P. (2024) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2024.05.022 · Cited by 14

Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease

Allen, S. J., & Morishita, H. (2024) · Science Advances · doi:10.1126/sciadv.adh3920 · Cited by 13

Prefrontal cortical circuits in social behaviors: an overview

Cao, W., Li, H., & Luo, J. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300743 · Cited by 14

Development of Prefrontal Circuits and Cognitive AbilitiesPreprint

Pöpplau, J. A., & Hanganu‐Opatz, I. L. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041502 · Cited by 15

Prefrontal encoding of an internal model for emotional inference

Gu, X., & Johansen, J. P. (2025) · Nature · doi:10.1038/s41586-025-09001-2 · Cited by 19

GABAergic interneurons’ feedback inhibition of dorsal raphe-projecting pyramidal neurons of the medial prefrontal cortex suppresses feeding of adolescent female mice undergoing activity-based anorexia

Du, M., Santiago, A. N., Akiz, C., & Aoki, C. J. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02507-9 · Cited by 12

Chemogenetic activation of prefrontal astroglia enhances recognition memory performance in rat

Delcourte, S., Bouloufa, A., Rovera, R., Betry, C., Abrial, E., Dkhissi‐Benyahya, O., Heinrich, C., Marcy, G., Raineteau, O., Haddjeri, N., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115384 · Cited by 13

A global transcriptional atlas of the effect of acute sleep deprivation in the mouse frontal cortex

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Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms

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Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection

Liu, Y., Jia, S., Wang, J., Wang, D., Zhang, X., Liu, H., Zhou, F., Zhang, Z., Li, Q., Dong, H., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1036428 · Cited by 12

Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice

Cortés, B. I., Meza, R. C., Ancatén-González, C., Ardiles, N. M., Aránguiz, M.-I., Tomita, H., Kaplan, D. R., Cornejo, F., Nunez-Parra, A., Moya, P. R., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00522-0 · Cited by 14

A prefrontal–habenular circuitry regulates social fear behaviour

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Distinct prelimbic cortex neuronal responses to emotional states of others drive emotion recognition in adult mice

Jabarin, R., Mohapatra, A. N., Ray, N., Netser, S., & Wagner, S. (2025) · Current Biology · doi:10.1016/j.cub.2025.01.014 · Cited by 15

Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol

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Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning

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