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Circuit organization of the rodent medial prefrontal cortex
Open accessAbstract
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion. They also communicate in the local network via specific connections between excitatory and inhibitory cells. In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.
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“mPFC L5 neurons are heterogenous populations, in terms of their molecular marker, synaptic properties, projection targets, local circuit integration, and functional specialization [15–18].”
From A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors (2026) · cites this paper as [15]
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Metadata
- Authors
- Anastasiades, P. G., & Carter, A. G.
- Affiliations
- University of Bristol (GB)
- New York University (US)
- Corresponding author
- Carter, Adam G.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 44
- Issue
- 7
- Pages
- 550-563
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC8222144
- OpenAlex
- W3159995594
- Cited by
- 314
- References
- 93
- Citations by year
- 2026: 81 · 2025: 90 · 2024: 67 · 2023: 46 · 2022: 25 · 2021: 4
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Explore Bristol Research (submittedVersion)
- Funders
- European Commission
- National Alliance for Research on Schizophrenia and Depression
- H2020 Marie Skłodowska-Curie Actions
- National Institutes of Health (R01 MH085974)
- Academy of Medical Sciences
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- medial prefrontal cortex, rodent brain, projection neurons, interneurons, excitatory-inhibitory interactions
- MeSH terms
- Animals, Humans, Interneurons, Rodentia, Prefrontal Cortex
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