Circuit organization of the rodent medial prefrontal cortex

An Integrative Theory of Prefrontal Cortex Function

Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803

A mesoscale connectome of the mouse brain

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GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033

The Prefrontal Cortex—An Update

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Shared and distinct transcriptomic cell types across neocortical areas

Tasic, B., Yao, Z., Graybuck, L. T., Smith, K. A., Nguyen, T. N., Bertagnolli, D., Goldy, J., Garren, E., Economo, M. N., Viswanathan, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0654-5 · Cited by 1,746

How Inhibition Shapes Cortical Activity

Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678

Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates

Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329

Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227

The neocortical circuit: themes and variations

Harris, K. D., & Shepherd, G. M. G. (2015) · Nature Neuroscience · doi:10.1038/nn.3917 · Cited by 1,215

Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear

Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190

Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice

Candemir, E., Fattakhov, N. S., O’Leary, A., Slattery, D. A., Courtney, M. J., Reif, A., & Freudenberg, F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.11.006 · Cited by 8

Corticotropin‐releasing factor signaling and its potential role in the prefrontal cortex‐dependent regulation of anxiety

Yang, X., & Geng, F. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25238 · Cited by 9

Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortexPreprint

Obray, J. D., Wilkes, E. T., Scofield, M. D., & Chandler, L. J. (2024) · eLife · doi:10.7554/elife.101667 · Cited by 9

The Atypical Dopamine Transporter Inhibitor CE-158 Enhances Dopamine Neurotransmission in the Prefrontal Cortex of Male Rats: A Behavioral, Electrophysiological, and Microdialysis Study

Sagheddu, C., Cancedda, E., Bagheri, F., Kalaba, P., Muntoni, A. L., Lubec, J., Lübec, G., Sanna, F., & Pistis, M. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad056 · Cited by 7

Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons

Rodrigues, D., & Monteiro, P. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100571 · Cited by 10

Viral vector-mediated transgene delivery with novel recombinase systems for targeting neuronal populations defined by multiple features

Jeong, M., Choi, J., Jang, H., Sohn, D. H., Wang, Q., Lee, J., Li, Y., Lee, E. J., Fan, J., Pratelli, M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.038 · Cited by 7

Clinical features and power spectral entropy of electroencephalography in Wilson's disease with dystonia

Zhang, S., Liu, A., Zhou, Z., Huang, Z., Cheng, J., Chen, D., Zhong, Q., Yu, Q., Peng, Z., & Hong, M. (2022) · Brain and Behavior · doi:10.1002/brb3.2791 · Cited by 7

Neural circuits controlling choice behavior in opioid addiction

Chang, V. N., & Peters, J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109407 · Cited by 7

Noradrenergic stimulation of α1 adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice

Niitani, K., Ito, S., Wada, S., Izumi, S., Nishitani, N., Deyama, S., & Kaneda, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-35242-0 · Cited by 8

Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin

Celora, L., Jaudon, F., Vitale, C., & Cingolani, L. A. (2023) · Molecular Brain · doi:10.1186/s13041-023-01031-z · Cited by 7

Early‐life IL ‐4 administration induces long‐term changes in microglia in the cerebellum and prefrontal cortex

Ferreira, P. A., Lebre, C., Costa, J., Amaral, F., Ferreira, R., Martinho, F., Paiva, V. H., Cardoso, A. L., Peça, J., & Guedes, J. R. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16266 · Cited by 6

Structural differences between human and mouse neurons and their implementation in generative AIs

Saiga, R., Shiga, K., Maruta, Y., Inomoto, C., Kajiwara, H., Nakamura, N., Kakimoto, Y., Yamamoto, Y., Yasutake, M., Uesugi, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-10912-3 · Cited by 8

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Uliana, D. L., & Grace, A. A. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70409 · Cited by 8

Disrupted synapses: prefrontal cortex-reward circuit dysfunction in stress-induced depression-like behaviors

Mahmud, A., & Karaman, M. A. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1843871 · Cited by 7

Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice

Cheng, X. R., Zhao, Y., Zheng, S., Zhao, P., Zou, J., Lin, W., Wu, W., & Ye, X. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01177-1 · Cited by 5

Insights into the encoding of memories through the circuitry of fear

Kenna, M., Marek, R., & Sah, P. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102712 · Cited by 6

Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse

Ren, M., Li, Y., Jiang, T., Liu, B., Li, X., Jia, X., Li, A., Luo, Q., Gong, H., & Li, X. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14552 · Cited by 5

From Play Date to Stress Fate: Juvenile Social Play Rescues Stress‐Induced Changes in Adult Social Behavior

Whitten, C. J., Kelly, J. R., Gillespie, A. L., Brooks, H. J. B., Hooker, M. K., Temple, A., Hennon, L. M., Kilgore, B. J., Singamaneni, Y. B., Schulz, K. M., et al. (2025) · Developmental Psychobiology · doi:10.1002/dev.70020 · Cited by 7

Neuroimmune regulation of the prefrontal cortex tetrapartite synapse

Liss, A., Siddiqi, M. T., Marsland, P., & Varodayan, F. P. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110335 · Cited by 8

Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Wu, H., Shen, L., Indajang, J., Savalia, N. K., Johnson, T. G., Qu, J., Bender, K. J., & Kwan, A. C. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2508836122 · Cited by 6

Preferential subcortical collateral projections of pedunculopontine nucleus-targeting cortical pyramidal neurons revealed by brain-wide single fiber tracing

Liu, Q.-Q., Cheng, Y., Jing, Q., Zhang, K., Ding, L., Fan, X.-W., Jia, C.-H., Xu, F., Bi, G., & Lau, P.-M. (2022) · Molecular Brain · doi:10.1186/s13041-022-00975-y · Cited by 6

Global Cerebral Ischemia-induced Depression Accompanies Alteration of Neuronal Excitability in the Infralimbic Cortex Layer 2/3 Pyramidal Neurons

Jang, D. C., Choi, S., Chung, G., & Kim, S. K. (2023) · Experimental Neurobiology · doi:10.5607/en23017 · Cited by 6

Border cells without theta rhythmicity in the medial prefrontal cortex

Long, X., Deng, B., Shen, R., Yang, L. S., Chen, L., Ran, Q., Du, X., & Zhang, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321614121 · Cited by 5

Layer-specific input to medial prefrontal cortex is linked to stress susceptibility

Solakoğlu, S. T., Erdener, Ş. E., Gliko, O., Can, A., Sümbül, U., & Eren-Koçak, E. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03258-x · Cited by 5

Suppression of mPFC‐Amygdala Circuit Mitigates Sevoflurane‐Induced Cognitive Deficits in Aged Mice

Li, J., Wen, J., Zeng, M., Mei, J., Zeng, C., Liufu, N., & Li, Y. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70443 · Cited by 5

Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation

Bryant, K. G., Swygart, D. I., Yin, Y., Bauer, M. R., Morningstar, M. D., Timme, N. M., Barnett, W. H., McGonigle, C. E., Engleman, E. A., Sheets, P. L., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112920 · Cited by 5

VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior

Barbano, M. F., Wang, H., Zhang, S., Shevelkin, A. V., Yu, K. R. T., Richie, C. T., Liu, B., Hahn, S., Ye, R., & Morales, M. (2025) · Nature Communications · doi:10.1038/s41467-025-63396-0 · Cited by 5

Dynamic θ Frequency Coordination within and between the Prefrontal Cortex-Hippocampus Circuit during Learning of a Spatial Avoidance Task

Dickson, C. R., Holmes, G. L., & Barry, J. M. (2022) · eNeuro · doi:10.1523/eneuro.0414-21.2022 · Cited by 7

Single cell transcriptomic representation of social dominance in prefrontal cortex and the influence of preweaning maternal and postweaning social environment

Lopez, K. C., Baker, M. R., & Tóth, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-52200-6 · Cited by 6

Psychostimulants and social behaviors

Cid-Jofré, V., Bahamondes, T., Correa, A. Z., Arias, I. A., Reyes-Parada, M. I., & Renard, G. M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1364630 · Cited by 6

Enhancing mPFC to BLA information transmission through chemical genetics to improve exploratory behavior in chronic stress rats

Guo, J., Cao, Q., Jie, H., Li, Y., Bai, W., Liu, T., & Zheng, X. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111335 · Cited by 5

Subclass‐specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices

Lanjewar, A. L., Jagetia, S., Khan, Z. M., Eagleson, K. L., & Levitt, P. R. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25418 · Cited by 4

A Global Transcriptional Atlas of the Effect of Sleep Deprivation in the Mouse Frontal CortexPreprint

Ford, K., Zuin, E., Righelli, D., Medina, E., Schoch, H., Singletary, K. G., Muheim, C., Frank, M. G., Hicks, S. C., Risso, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.28.569011 · Cited by 4

Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer’s model mice

Cunliffe, G., Tan, L. Y., Jung, S., Turner, J., & Gigg, J. (2025) · Communications Biology · doi:10.1038/s42003-025-08546-2 · Cited by 4

Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice

Yuan, Y., Li, Y., Yang, F., Jiang, Y., Ding, Y., Xiao, Y., Zhu, X., Shu, X., Huang, X., Wang, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03370-w · Cited by 6

Prefrontal ErbB4-positive interneurons for avoidance

Cui, W., Shen, C., Xiong, W., & Mei, L. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115628 · Cited by 4

Metabotropic glutamate receptors and cognition: From underlying plasticity and neuroprotection to cognitive disorders and therapeutic targets

Hoglund, B. K., Carfagno, V. F., Olive, M. F., & Leyrer‐Jackson, J. M. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.10.004 · Cited by 4

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice

Cook, A. K., Greathouse, K. M., Manuel, P. N., Cooper, N. H., Eberhardt, J. M., Freeman, C. D., Weber, A. J., Herskowitz, J. H., & Arrant, A. E. (2024) · Molecular Brain · doi:10.1186/s13041-024-01095-5 · Cited by 4

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

Razenberg, L., de Greef, P. N., Mansvelder, H. D., & Karnani, M. (2026) · The Journal of Physiology · doi:10.1113/jp288596 · Cited by 5

Exploring Cortical Interneurons in Substance Use Disorder: From Mechanisms to Therapeutic Perspectives

Shi, S., Chen, T., Su, H., & Zhao, M. (2025) · The Neuroscientist · doi:10.1177/10738584241310156 · Cited by 4

Astrocyte reactivity in the glia limitans superficialis of the rat medial prefrontal cortex following sciatic nerve injury

Bretová, K., Svobodová, V., & Dubový, P. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02161-6 · Cited by 4

Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (CaV) Subtypes in mPFC Neurons

McCarthy, C. I., Mustafá, E. R., Cornejo, M. P., Yaneff, A., Rodríguez, S. S., Perelló, M., & Raingo, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03221-1 · Cited by 5

Homeostasis to Allostasis: Prefrontal Astrocyte Roles in Cognitive Flexibility and Stress Biology

Wulaer, B., Holtz, M., & Nagai, J. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_6 · Cited by 4

Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear

Oliveira, G. V. M., Hernandes, P. M., dos Santos, F. H., Soares, V. P. M. N., Falconi‐Sobrinho, L. L., Coimbra, N. C., Wotjak, C. T., & Almada, R. C. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06701-x · Cited by 3

Cortical and subcortical activities during food rewards versus social interaction in rats

Rocha-Almeida, F., Conde-Moro, A. R., Fernández‐Ruiz, A., Delgado-Garcia, J. M., & Gruart, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-87880-1 · Cited by 3

The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning

Lozano, K., Felix‐Ortiz, A. C., Terrell, J. M., Gonzalez, C., Whitehorn, K. R., Kanke, A. E., Villalon, S. A., Ramos, A. R., Miller, A. N., Rodríguez-Romaguera, J., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02073-8 · Cited by 4

Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism

Vitale, C., Jaudon, F., Luján, R., Bartolucci, M., Celora, L., Reisoli, E., Ruggeri, R., Petretto, A., Thalhammer, A., & Cingolani, L. A. (2025) · Brain · doi:10.1093/brain/awaf089 · Cited by 3

Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake

Lovinger, D. M. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.05.005 · Cited by 3

Sex differences in noradrenergic regulation of the medial prefrontal cortex in mice

Scroger, M. V., Athanason, A. C., Paperny, N. M., Liss, A., Võ, K. L., Muneeb, M., Siddiqi, M. T., Batchelder, M., Shahbaz, I., Chan, S., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00779-4 · Cited by 4

Disrupted Development of the mPFC-Thalamic Circuit in Shank3–/– mice, an autism-associated model

Devienne, G. F., Vantomme, G., & Huguenard, J. R. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03390-6 · Cited by 3

A systematic review of the neurobiological mechanisms of chemotherapy-induced deficits in executive functions

Chen, W., & Johnston, I. N. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101161 · Cited by 4

Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior

Boroujeni, K. B., Balaram, P., Tiesinga, P. H. E., & Womelsdorf, T. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102873 · Cited by 4

A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice

Xie, G., Liu, Y., Qi, X., Bhattacherjee, A., Zhang, C., & Zhang, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-69001-2 · Cited by 4

Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks

Osako, Y., Heller, G. R., Ährlund‐Richter, S., Buschman, T. J., & Sur, M. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02410-0 · Cited by 6

Methamphetamine produces behavioral flexibility deficits that are attenuated by COX-2 inhibition in both male and female rats

Acuña, A. M., Rodarte, S. E., Bickley, S., Nagy, E. K., Peacock, E., Carlson, A., Overby, P. F., & Olive, M. F. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100207 · Cited by 3

Long‐Term Memory Engrams From Development to Adulthood

Yu, A. L., & DeNardo, L. A. (2025) · Hippocampus · doi:10.1002/hipo.70032 · Cited by 4

Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction

Ponserre, M., Ionescu, T. M., Franz, A. A., Deiana, S., Schuelert, N., Lamla, T., Williams, R. H., Wotjak, C. T., Hobson, S., Dine, J., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109970 · Cited by 4

Divergent subregional information processing in mouse prefrontal cortex during working memory

Sonneborn, A., Bartlett, L., Olson, R. J., Milton, R., & Abbas, A. I. (2024) · Communications Biology · doi:10.1038/s42003-024-06926-8 · Cited by 3

Distinct behavioural and neurovascular signatures induced by acute and chronic stress in rats

Simões, D. M., Carreira, J., Henriques, A., Gaspar, R., Sanches, E. S., Baptista, F. I., & Silva, A. P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115706 · Cited by 4

The infralimbic and prelimbic cortical areas bidirectionally regulate safety learning during normal and stress conditionsPreprint

Felix‐Ortiz, A. C., Terrell, J. M., Gonzalez, C., Msengi, H. D., Ramos, A. R., Boggan, M. B., Lopez-Pesina, S. M., Magalhães, G., & Burgos-Robles, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.05.539516 · Cited by 3

Inferring the time-varying coupling of dynamical systems with temporal convolutional autoencodersPreprint

Calderon, J., & Berman, G. J. (2024) · eLife · doi:10.7554/elife.100692.1 · Cited by 3

Behavioral and genetic markers of susceptibility to escalate fentanyl intakePreprint

Keady, J. V., Charnigo, R. J., Shaykin, J. D., Prantzalos, E. R., Xia, M., Denehy, E. D., Bumgardner, C., Miller, J. B., Ortinski, P. I., Bardo, M. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.06.627259 · Cited by 3

Diverse activity in prefrontal projections promotes temporal control of actionPreprint

Ding, X., Weber, M. A., Butler, T. C., Bova, A. S., Guerrero, S., Hunter, C., Cole, R. C., Stutt, H. R., McMurrin, M. S., Spicer, M. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.12.653607 · Cited by 3

24-hour simultaneous mPFC’s miniature 2-photon imaging, EEG-EMG, and video recording during natural behaviors

Han, J., Zhou, F., Zhao, Z., Zhang, D., Chen, X., Wang, L., Zhao, T., Ye, W., Gu, X., Fang, H., et al. (2025) · Scientific Data · doi:10.1038/s41597-025-05527-2 · Cited by 4

Neurotensin-specific corticothalamic circuit regulates innate response conflict

Park, G., Park, Y., Yang, S., Cho, Y., Serikov, A., Jung, D., Seo, D.-C., Lee, S. E., Nam, M., Kim, D., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.06.068 · Cited by 2

Alterations in dendritic spine plasticity in the prefrontal cortex induced by social play restrictions in male rats

Escribano-Cadena, Y., Tendilla‐Beltrán, H., & Flores, G. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.07.041 · Cited by 3

The role of corticolimbic perineuronal nets in mice with chronic neuropathic pain

Cermak, S., Sekerková, G., Martina, M., & Apkarian, A. V. (2025) · Pain · doi:10.1097/j.pain.0000000000003825 · Cited by 2

Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses

Schamiloglu, S., Clarkson, R. L., Stone, N. S., Liptak, A. T., & Bender, K. J. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1080-25.2025 · Cited by 2

Syn III participated in rTMS-modulated emotional rescue in the prefrontal cortex under simulated space composite environment

Liang, R., Meng, L., Liu, X., Zhu, J., Wang, L., Ren, J., Zhao, M., Liu, J., Zheng, C., Yang, J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03393-3 · Cited by 2

Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior

Han, M., Tan, H. L., Mejı́as, R., Chiu, S., Kim, J., Huganir, R. L., & Wang, T. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03415-0 · Cited by 2

Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling

Xiang, J., Shi, M., Kang, J., Zhang, X., Ling, J., Zhan, W., Li, D., Hu, R. K., & Xu, H. (2026) · Cell Discovery · doi:10.1038/s41421-025-00857-2 · Cited by 2

Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex

Gutman-Wei, A. Y., Sudarsanam, S., Cabalinan, A. G., Shahid, N., Shi, A., Guzman-Clavel, L., Spindler-Krage, S. M., Agarwal, A., Kolodkin, A. L., & Brown, S. P. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116792 · Cited by 2

Oxytocin attenuates fear learning via enhancing somatostatin interneuron–mediated local GABAergic inhibition in the prelimbic cortex

Xu, H., LI, Y., Cui, X., Zhang, Y., Wu, X., Zhuo, S. S., He, M., & Xiao, L. (2026) · Science Advances · doi:10.1126/sciadv.aef8400 · Cited by 2

A retinoic acid autoregulatory loop governing prefrontal–motor arealization

Yang, L., Shibata, M., Park, S., Liu, Y., Salamon, I., Liu, J., Kim, S., Shibata, A., Deveau-French, A., Mato-Blanco, X., et al. (2026) · Nature · doi:10.1038/s41586-026-11014-4 · Cited by 4

Bimodal modulation of L1 interneuron activity in anterior cingulate cortex during fear conditioning

Fossati, G., Kiss-Bodolay, D., Prados, J., Chéreau, R., Husi, E., Cadilhac, C., Gómez, L., Silva, B. A., Dayer, A. G., & Holtmaat, A. J. D. G. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1138358 · Cited by 3

Functional-based parcellation of the mouse prefrontal cortex for network perturbation analysis

Savvateev, I., Grimm, C., Markicevic, M., Grandjean, J., Sastre-Yagüe, D., Gozzi, A., Wenderoth, N., Polanía, R. H., & Zerbi, V. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115622 · Cited by 2

Sex-Dependent Effects of Angiotensin Type 2 Receptor–Expressing Medial Prefrontal Cortex Interneurons in Fear Extinction Learning

Smith, H. C., Yu, Z., Iyer, L., & Marvar, P. J. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100340 · Cited by 2

Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity

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Sex Differences in Neural Circuits Underlying Fear Processing

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Heterogeneity of Layer 1 Interneurons in the Mouse Medial Prefrontal Cortex

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Regulation of perisomatic synapses from cholecystokinin basket interneurons through NrCAM and Ankyrin B

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Prelimbic cortical excitatory overdrive and inhibitory underdrive accompany environmental suppression of food seeking

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Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner

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The Top-Down of Prefrontal Cortex to the Hippocampus Glutamatergic Pathway Regulates Reward Memory of Methamphetamine

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Sex-Dependent Effects of Angiotensin Type 2 Receptor Expressing Medial Prefrontal Cortex (mPFC) Interneurons in Fear Extinction Learning

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Adolescent Thalamocortical Inhibition Alters Prefrontal Excitation-Inhibition BalancePreprint

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Maternal cannabis use alters excitatory inputs to corticostriatal efferent neurons in rat offspringPreprint

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Rule-based modulation of a sensorimotor transformation across cortical areasPreprint

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Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposurePreprint

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A role for the prefrontal cortex in reward, punishment, and animal behavior: An anatomical/functional framework

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VTA Excitatory Neurons Control Reward-driven Behavior by Modulating Infralimbic Cortical Firing

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Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

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Prenatal Downregulation of CB 1 Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Deficits

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Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors

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Insular Input to the Prelimbic Cortex Underlies Social Affective Behavior in Rats

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Layer-Specific Glutamatergic Inputs and Parvalbumin Interneurons Modulate Early Life Stress-Induced Alterations in Prefrontal Glutamate Release during Fear Conditioning in Pre-adolescent Rats

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Prefrontal cortex down states can be triggered by CA1 stimulation and are enhanced by long-term potentiation in urethane-anesthetized rats

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Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats

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Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models

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Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

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