Cited by 323Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Circuit organization of the rodent medial prefrontal cortex

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Anastasiades, Paul G., Carter, Adam G.·2021·Trends in Neurosciences

DOI 10.1016/j.tins.2021.03.006PMC PMC8222144

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Abstract

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion. They also communicate in the local network via specific connections between excitatory and inhibitory cells. In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.

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Authors: Anastasiades, P. G., & Carter, A. G.
Affiliations: University of Bristol (GB)
New York University (US)
Corresponding author: Carter, Adam G.
ORCID: Anastasiades, Paul G.
Carter, Adam G.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2021-07
Volume: 44
Issue: 7
Pages: 550-563
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2021.03.006
PMC: PMC8222144
OpenAlex: W3159995594
Cited by: 314
References: 93
Citations by year: 2026: 81 · 2025: 90 · 2024: 67 · 2023: 46 · 2022: 25 · 2021: 4
FWCI: 5.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Explore Bristol Research (submittedVersion)
Funders: European Commission
National Alliance for Research on Schizophrenia and Depression
H2020 Marie Skłodowska-Curie Actions
National Institutes of Health (R01 MH085974)
Academy of Medical Sciences
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: medial prefrontal cortex, rodent brain, projection neurons, interneurons, excitatory-inhibitory interactions
MeSH terms: Animals, Humans, Interneurons, Rodentia, Prefrontal Cortex

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