Cited by 209Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Optogenetic dissection of medial prefrontal cortex circuitry

Open access
Riga, Danai, Matos, Mariana R., Glas, Annet, Smit, August B., Spijker, Sabine, Van den Oever, Michel C.·2014·Frontiers in Systems Neuroscience

Abstract

The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions, including attention, inhibitory control, habit formation, working memory and long-term memory. Moreover, through its dense interconnectivity with subcortical regions (e.g., thalamus, striatum, amygdala and hippocampus), the mPFC is thought to exert top-down executive control over the processing of aversive and appetitive stimuli. Because the mPFC has been implicated in the processing of a wide range of cognitive and emotional stimuli, it is thought to function as a central hub in the brain circuitry mediating symptoms of psychiatric disorders. New optogenetics technology enables anatomical and functional dissection of mPFC circuitry with unprecedented spatial and temporal resolution. This provides important novel insights in the contribution of specific neuronal subpopulations and their connectivity to mPFC function in health and disease states. In this review, we present the current knowledge obtained with optogenetic methods concerning mPFC function and dysfunction and integrate this with findings from traditional intervention approaches used to investigate the mPFC circuitry in animal models of cognitive processing and psychiatric disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fnsys.2014.00230

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The PFC exerts top-down control over a variety of subcortical regions, and recent research has identified a number of circuits originating in the PFC that control behaviors relevant to the treatment of depression, anxiety, and addiction.

    “The PFC is known to exert top-down control over a variety of subcortical regions, and recent research has identified a number of circuits originating in the PFC that control behaviors relevant to the treatment of depression, anxiety, and addiction (Figure 3) (56, 173).”
  • Non-selective activation of the mPFC can reverse behavioral deficits in depression models.

    “Our findings build upon prior studies showing that non-selective activation of the mPFC can reverse behavioral deficits in depression models [36–39]”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Ralph R. J. Varty G. B. Kelly M. A. Wang Y. M. Caron M. G. Rubinstein M.. (1999). The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. J. Neurosci. 19, 4627– 4633. 10341260 PMC6782596

Cited by

Sorted by citations

Authors
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C.
Affiliations
Amsterdam Neuroscience (NL)
Venue
Frontiers in Systems Neuroscience
Published
2014-12-09
Volume
8
Pages
230-230
ISSN
1662-5137 (ISSN-L)
OpenAlex
W2035346633
Cited by
208
References
203
Citations by year
2026: 5 · 2025: 10 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 29 · 2020: 22 · 2019: 20 · 2018: 15 · 2017: 19 · 2016: 25 · 2015: 10
FWCI
2.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • ZonMw
  • Hersenstichting
  • FP7 People: Marie-Curie Actions (607508, FP7-PEOPLE-2013-ITN, FP7-PEOPLE-2013)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
medial prefrontal cortex, optogenetics, neural circuits, neuronal subpopulations, mental illness, cognitive processes, animal models

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review