Cited by 175Neuroinflammation and Neurodegeneration MechanismsInflammatory mediators and NSAID effectsTraumatic Brain Injury and Neurovascular Disturbances

To be or not to be (inflamed)—is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?

Marchetti, Bianca, Abbracchio, Maria P.·2005·Trends in Pharmacological Sciences

Abstract

A sustained inflammatory reaction is present in acute (e.g. stroke) and chronic (e.g. Alzheimer's disease, Parkinson's disease and multiple sclerosis) neurodegenerative disorders. Inflammation, which is fostered by both residential glial cells and blood-circulating cells that infiltrate the diseased brain, probably starts as a time- and site-specific defense mechanism that could later evolve into a destructive and uncontrolled reaction. In this article, we review the crucial dichotomy of brain inflammation, where failure to resolve an acute beneficial response could lead to a vicious and anarchic state of chronic activation. The possible use of non-steroidal anti-inflammatory drugs for the management of neurodegenerative diseases is discussed in light of recent data demonstrating a neuroprotective role of local innate and adaptive immune responses. Novel therapeutic approaches must rely on potentiation of endogenous anti-inflammatory pathways, identification of early markers of neuronal deterioration and a combination treatment involving immune modulation and anti-inflammatory therapies.

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Crossref · 10.1016/j.tips.2005.08.007

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Authors
Marchetti, B., & Abbracchio, M. P.
Affiliations
  • University of Sassari (IT)
  • University of Milan (IT)
Corresponding author
  • Marchetti, Bianca
  • Abbracchio, Maria P.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2005-10
Volume
26
Issue
10
Pages
517-525
ISSN
0165-6147 (ISSN-L)
OpenAlex
W2017364016
Cited by
175
References
74
Citations by year
2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 10
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca (189)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
neuroinflammation, neurodegenerative diseases, anti-inflammatory agents, nonsteroidal anti-inflammatory drugs, Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, microglia, neuroprotection, innate immune response, adaptive immune response, immunomodulation
MeSH terms
Animals, Anti-Inflammatory Agents, Encephalitis, Humans, Immunity, Innate, Neurodegenerative Diseases

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