To be or not to be (inflamed)—is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?
Abstract
A sustained inflammatory reaction is present in acute (e.g. stroke) and chronic (e.g. Alzheimer's disease, Parkinson's disease and multiple sclerosis) neurodegenerative disorders. Inflammation, which is fostered by both residential glial cells and blood-circulating cells that infiltrate the diseased brain, probably starts as a time- and site-specific defense mechanism that could later evolve into a destructive and uncontrolled reaction. In this article, we review the crucial dichotomy of brain inflammation, where failure to resolve an acute beneficial response could lead to a vicious and anarchic state of chronic activation. The possible use of non-steroidal anti-inflammatory drugs for the management of neurodegenerative diseases is discussed in light of recent data demonstrating a neuroprotective role of local innate and adaptive immune responses. Novel therapeutic approaches must rely on potentiation of endogenous anti-inflammatory pathways, identification of early markers of neuronal deterioration and a combination treatment involving immune modulation and anti-inflammatory therapies.
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There is a strong immune component in Parkinson's disease.
“Yet it is well recognized that there is a strong immune component in PD 110.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [110]
Cites
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury
Faulkner, J., Herrmann, J., Woo, M. J., Tansey, K., Doan, N., & Sofroniew, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3547-03.2004 · Cited by 1,600 · see citing works
McGeer, P. L., Schulzer, M., & McGeer, E. G. (1996) · Neurology · doi:10.1212/wnl.47.2.425 · Cited by 1,367 · see citing works
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
Pluchino, S., Zanotti, L., Rossi, B., Brambilla, E., Ottoboni, L., Salani, G., Martinello, M., Cattalini, A., Bergami, A., Furlan, R., et al. (2005) · Nature · doi:10.1038/nature03889 · Cited by 762 · see citing works
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., et al. (2005) · Nature Medicine · doi:10.1038/nm1177 · Cited by 732 · see citing works
Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease
Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 630 · see citing works
Inflammation and neurodegeneration in Parkinson's disease
McGeer, P. L., & McGeer, E. G. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.01.005 · Cited by 628 · see citing works
Perry, V. H. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.01.004 · Cited by 560 · see citing works
Pro‐regenerative properties of cytokine‐activated astrocytes
Liberto, C. M., Albrecht, P. J., Herx, L. M., Yong, V. W., & Levison, S. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02420.x · Cited by 464 · see citing works
Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases
Mandel, S. A., & Youdim, M. B. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.012 · Cited by 443 · see citing works
Visualising microglial activation in vivo
Banati, R. B. (2002) · Glia · doi:10.1002/glia.10144 · Cited by 428 · see citing works
FRANCHIMONT, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.009 · Cited by 408 · see citing works
Genetic and environmental factors in the cause of Parkinson's disease
Warner, T. T., & Schapira, A. H. V. (2003) · Annals of Neurology · doi:10.1002/ana.10487 · Cited by 399 · see citing works
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
Vegeto, E., Belcredito, S., Etteri, S., Ghisletti, S., Brusadelli, A., Meda, C., Krust, A., Dupont, S., Ciana, P., Chambon, P., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531957100 · Cited by 384 · see citing works
Dehmer, T., Heneka, M. T., Sastre, M., DICHGANS, J., & Schulz, J. B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02210.x · Cited by 382 · see citing works
Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367 · see citing works
Cannabinoids and neuroinflammation
Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 334 · see citing works
Novel anti-inflammatory therapy for Parkinson's disease
Gao, H., Liu, B., Zhang, W., & Hong, J. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00176-7 · Cited by 324 · see citing works
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
Benner, E. J., Mosley, R. L., Destache, C. J., Lewis, T. B., Jackson-Lewis, V. R., Gorantla, S., Nemachek, C., Green, S. R., Przedborski, S., & Gendelman, H. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400569101 · Cited by 321 · see citing works
Reduced incidence of AD with NSAID but not H2receptor antagonists
Zandi, P. P., Anthony, J. C., Hayden, K. M., Mehta, K. M., Mayer, L. S., & Breitner, J. C. S. (2002) · Neurology · doi:10.1212/wnl.59.6.880 · Cited by 314 · see citing works
Inflammation and Infection in Clinical Stroke
Emsley, H. C. A., & Tyrrell, P. J. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000037880.62590.28 · Cited by 277 · see citing works
Microglia and neuroprotection: implications for Alzheimer's disease
Streit, W. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.013 · Cited by 256 · see citing works
Cytokines in Neuroinflammation and Alzheimers Disease
Cacquevel, M., Lebeurrier, N., Chéenne, S., & Vivien, D. (2004) · Current Drug Targets · doi:10.2174/1389450043345308 · Cited by 245 · see citing works
Macrophages and neurodegeneration
Hendriks, J. J. A., Teunissen, C. E., de Vries, H. E., & Dijkstra, C. D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.008 · Cited by 241 · see citing works
Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones
García‐Ovejero, D., Azcoitia, Í., DonCarlos, L. L., Melcangi, R. C., & García‐Segura, L. M. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.018 · Cited by 220 · see citing works
Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease
Lovett‐Racke, A. E., Hussain, R. Z., Northrop, S. C., Choy, J., Rocchini, A., Matthes, L., Chavis, J. A., Diab, A., Drew, P. D., & Racke, M. K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5790 · Cited by 207 · see citing works
Morale, M. C., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Gennuso, F., Giaquinta, G., Rocchitta, G., Desole, M. S., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.060 · Cited by 207 · see citing works
Self-citationNeuroinflammatory perspectives on the two faces of Alzheimer?s disease
Eikelenboom, P., & van Gool, W. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0055-1 · Cited by 181 · see citing works
COX‐2 and Neurodegeneration in Parkinson's Disease
Teismann, P., Vila, M., Choi, D., Tieu, K., Wu, D.-C., Jackson-Lewis, V. R., & Przedborski, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07482.x · Cited by 178 · see citing works
Pathogenesis of multiple sclerosis
Prat, A., & Antel, J. P. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169737.99040.31 · Cited by 158 · see citing works
Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
Mandel, S., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.027 · Cited by 157 · see citing works
Interactions between Alzheimer's disease and cerebral ischemia—focus on inflammation
Koistinaho, M., & Koıstınaho, J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.014 · Cited by 148 · see citing works
Frenkel, D., Huang, Z., Maron, R., Koldzic, D. N., Hancock, W. W., Moskowitz, M. A., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6549 · Cited by 147 · see citing works
Hauwel, M., Furon, E., Canova, C., Griffiths, M., Neal, J. W., & Gasque, P. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.012 · Cited by 142 · see citing works
Dahlqvist, P. M., Rönnbäck, A., Bergström, S., Söderström, I., & Olsson, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03248.x · Cited by 140 · see citing works
Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review
Willenborg, D. O., Staykova, M. A., & Cowden, W. B. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00212-x · Cited by 136 · see citing works
Cytokine and chemokine inter-regulation in the inflamed or injured CNS
Owens, T., Babcock, A. A., Millward, J. M., & Toft‐Hansen, H. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.007 · Cited by 131 · see citing works
COLE, G. M., MORIHARA, T., LIM, G. P., YANG, F., BEGUM, A., & FRAUTSCHY, S. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.005 · Cited by 129 · see citing works
New insights into COX-2 biology and inhibition
Patrignani, P., Tacconelli, S., Sciulli, M. G., & Capone, M. L. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.024 · Cited by 128 · see citing works
Lévecque, C. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg009 · Cited by 125 · see citing works
Ling, Z. D., Chang, Q., Lipton, J. W., Tong, C. W., Landers, T. M., & Carvey, P. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.017 · Cited by 114 · see citing works
Schwartz, M., & Kipnis, J. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.014 · Cited by 110 · see citing works
Immunomodulation in multiple sclerosis: from immunosuppression to neuroprotection
Neuhaus, O., Archelos, J. J., & Hartung, H. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00028-2 · Cited by 108 · see citing works
Cholesterol-independent Effects of Statins and New Therapeutic Targets: Ischemic Stroke and Dementia
Miida, T., Hirayama, S., & Nakamura, Y. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.253 · Cited by 97 · see citing works
Cytokine genes and disease susceptibility
Ollier, W. (2004) · Cytokine · doi:10.1016/j.cyto.2004.07.014 · Cited by 96 · see citing works
Martino, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00771-9 · Cited by 86 · see citing works
Håkansson, A. S., Westberg, L., Nilsson, S., Buervenich, S., Belin, A. C., Holmberg, B., Sydow, O., Olson, L., Johnels, B., Eriksson, E., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30136 · Cited by 83 · see citing works
Association between the interleukin-1α gene and Alzheimer’s disease: a meta-analysis
Rainero, I., Bo, M., Ferrero, M., Valfrè, W., Vaula, G., & Pinessi, L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.011 · Cited by 79 · see citing works
Neuroprotection for Parkinson's disease: Prospects and promises
Olanow, C. W., Schapira, A. H. V., & Agid, Y. (2003) · Annals of Neurology · doi:10.1002/ana.10566 · Cited by 75 · see citing works
Morale, M. C., Serra, P. A., Delogu, M. R., Migheli, R., Rocchitta, G., Tirolo, C., Caniglia, S., Testa, N., L’Episcopo, F., Gennuso, F., et al. (2003) · The FASEB Journal · doi:10.1096/fj.03-0501fje · Cited by 71 · see citing works
Self-citationInflammation and dopaminergic neuronal loss in Parkinson's disease: a complex matter
Hartmann, A., Hunot, S., & Hirsch, É. C. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.08.004 · Cited by 70 · see citing works
Marchetti, B., Morale, M. C., Testa, N., Tirolo, C., Caniglia, S., Amor, S., Dijkstra, C. D., & Barden, N. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00130-8 · Cited by 62 · see citing works
Self-citationAnti-inflammatory therapy in Alzheimer?s disease: is hope still alive?
van Gool, W. A., Aisen, P. S. S., & Eikelenboom, P. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1146-5 · Cited by 61 · see citing works
Marchetti, B., Serra, P. A., Tirolo, C., L’Episcopo, F., Caniglia, S., Gennuso, F., Testa, N., MIELE, E., Desole, S., Barden, N., et al. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.030 · Cited by 58 · see citing works
Self-citationArnaiz, S. L., D’Amico, G., Paglia, N., Arismendi, M., Basso, N., & Arnaiz, M. D. R. L. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.011 · Cited by 53 · see citing works
From proteomics to biomarker discovery in Alzheimer's disease
Ho, L., Sharma, N., Blackman, L., Festa, E. D., Reddy, G., & Pasinetti, G. M. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.025 · Cited by 49 · see citing works
Biomarkers for apoptosis in Alzheimer's disease
Ankarcrona, M., & Winblad, B. G. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1260 · Cited by 46 · see citing works
Modulation of Cyclooxygenase‐2 and Brain Reactive Astrogliosis by Purinergic P2 Receptors
Brambilla, R., & Abbracchio, M. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03612.x · Cited by 44 · see citing works
Self-citationLigands for peripheral benzodiazepine binding sites in glial cells
Kassiou, M., Meikle, S. R., & Banati, R. B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.010 · Cited by 40 · see citing works
Licastro, F., Veglia, F., Chiappelli, M., Grimaldi, L. M. E., & Masliah, E. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.002 · Cited by 38 · see citing works
Marchetti, B., Morale, M. C., Brouwer, J. P., Tirolo, C., Testa, N., Caniglia, S., Barden, N., Amor, S., Smith, P. A., & Dijkstra, C. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5848 · Cited by 36 · see citing works
Self-citationCapecchi, P. L., Camurri, A., Pompella, G., Mazzola, A., Maccherini, M., Diciolla, F., Lazzerini, P. E., Abbracchio, M. P., & Pasini, F. L. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2004.04.005 · Cited by 36 · see citing works
Self-citationHormone regulation of microglial cell activation: relevance to multiple sclerosis
Drew, P. D., Storer, P. D., Xu, J., & Chavis, J. A. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.020 · Cited by 36 · see citing works
Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson Neurodegeneration
Schiess, M. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1043 · Cited by 34 · see citing works
High frequency of TNF alleles $minus;238A and $minus;376A in individuals from northern Sardinia
Wirz, S. (2004) · Cytokine · doi:10.1016/j.cyto.2004.02.006 · Cited by 30 · see citing works
Furlan, R., Kurne, A., Bergami, A., Brambilla, E., Maucci, R., Gasparini, L., Butti, E., Comı, G., Ongini, E., & Martino, G. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.004 · Cited by 26 · see citing works
Marchetti, B., Kettenmann, H., & Streit, W. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.002 · Cited by 23 · see citing works
Self-citationGonzález, L. C. Á., Freijo-Guerrero, M. M., & Sádaba-Garay, F. (2002) · Revista de Neurología · doi:10.33588/rn.3505.2002019 · Cited by 22 · see citing works
Moon, C., Ahn, M., Jee, Y., Heo, S., Kim, S., Kim, H., Sim, K., Koh, C., Shin, Y., & Shin, T. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.038 · Cited by 20 · see citing works
Weinberg, J. M. (2005) · PubMed · Cited by 14 · see citing works
Cyclo-oxygenase inhibitors and Alzheimer's: are we well ADAPTed?
Pasinetti, G. M., & Pompl, P. N. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00214-4 · Cited by 9 · see citing works
Aisen, P. S., Schafer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., Farlow, M. R., Jin, S., Thomas, R. G., Thal, L. J., et al. (2003) · JAMA · doi:10.1001/jama.289.21.2819 · Cited by 5 · see citing works
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Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
Gao, H., & Hong, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.05.002 · Cited by 822 · see citing works
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
Glial reactions in Parkinson's disease
McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701 · see citing works
Tansey, M. G., McCoy, M. K., & Frank-Cannon, T. C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.004 · Cited by 580 · see citing works
Sas, K., Robotka, H., Toldi, J., & Vécsei, L. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.033 · Cited by 465 · see citing works
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Qiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., Salomone, S., & Moskowitz, M. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600582 · Cited by 405 · see citing works
Vegeto, E., Benedusi, V., & Maggi, A. C. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.04.001 · Cited by 356 · see citing works
Bureau, G., Longpré, F., & Martinoli, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21503 · Cited by 336 · see citing works
Buffo, A., Rolando, C., & Ceruti, S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.014 · Cited by 321 · see citing works
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Leonard, B. E. (2010) · Current Immunology Reviews · doi:10.2174/157339510791823835 · Cited by 296 · see citing works
Non-steroidal anti-inflammatory drugs in Parkinson's disease
Esposito, E., Matteo, V. D., Benigno, A., Pierucci, M., Crescimanno, G., & Giovanni, G. D. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.02.008 · Cited by 232 · see citing works
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Leggio, L., Vivarelli, S., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Marchetti, B., & Iraci, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122698 · Cited by 216 · see citing works
Self-citationLee, D.-H., Kim, C., & Lee, Y. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.10.029 · Cited by 214 · see citing works
Villarán, R. F., Espinosa‐Oliva, A. M., Soto, M. S., de Pablos, R. M., Argüelles, S., Delgado‐Cortés, M. J., Sobrino, V., van Rooijen, N., Venero, J. L., Herrera, A. J., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06879.x · Cited by 214 · see citing works
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Virgilio, F. D., Ceruti, S., Bramanti, P., & Abbracchio, M. P. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.003 · Cited by 210 · see citing works
Self-citationMorale, M. C., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Gennuso, F., Giaquinta, G., Rocchitta, G., Desole, M. S., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.060 · Cited by 207 · see citing works
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Klegeris, A., McGeer, E. G., & McGeer, P. L. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3280adc943 · Cited by 186 · see citing works
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Franke, H., Krügel, U., & Illés, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0071-8 · Cited by 184 · see citing works
Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
Sandhir, R., Onyszchuk, G., & Berman, N. E. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.06.013 · Cited by 184 · see citing works
Kim, K. H., Lee, D., Lee, H. L., Kim, C.-E., Jung, K., & Kang, K. S. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.03.011 · Cited by 184 · see citing works
The endocannabinoid system in targeting inflammatory neurodegenerative diseases
Centonze, D., Finazzi‐Agrò, A., Bernardi, G., & Maccarrone, M. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.004 · Cited by 180 · see citing works
Marchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 185 · see citing works
Self-citationResveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice
Blanchet, J., Longpré, F., Bureau, G., Morissette, M., Paolo, T. D., Bronchti, G., & Martinoli, M. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.03.024 · Cited by 177 · see citing works
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Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 167 · see citing works
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Madinier, A., Bertrand, N., Mossiat, C. M., Prigent‐Tessier, A., Beley, A., Marie, C., & Garnier, P. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008101 · Cited by 154 · see citing works
Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells
Stichel, C. C., & Luebbert, H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.022 · Cited by 151 · see citing works
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Kannappan, R., Gupta, S. C., Kim, J. H., Reuter, S., & Aggarwal, B. B. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8168-2 · Cited by 150 · see citing works
Interaction of curcumin with Zn(II) and Cu(II) ions based on experiment and theoretical calculation
Zhao, X.-Z., Jiang, T., Wang, L., Yang, H., Zhang, S., & Zhou, P. (2010) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2010.09.049 · Cited by 145 · see citing works
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Esposito, E., Impellizzeri, D., Mazzon, E., Paterniti, I., & Cuzzocrea, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041880 · Cited by 144 · see citing works
Campolo, M., Paterniti, I., Siracusa, R., Filippone, A., Esposito, E., & Cuzzocrea, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.12.003 · Cited by 143 · see citing works
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Lee, J., & Tansey, M. G. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-520-0_3 · Cited by 141 · see citing works
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Raffaele, S., Lombardi, M., Verderio, C., & Fumagalli, M. (2020) · Cells · doi:10.3390/cells9102145 · Cited by 140 · see citing works
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Abdou, E., & Hazell, A. S. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1430-z · Cited by 139 · see citing works
L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Deleidi, M., Serapide, M. F., Pluchino, S., & Marchetti, B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5259-11.2012 · Cited by 135 · see citing works
Self-citationMarchetti, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123743 · Cited by 130 · see citing works
Self-citationdo Carmo, M. R. S., Menezes, A. P. F., Nunes, A. C. L., Pliássova, A., Rolo, A. P., Palmeira, C. M., Cunha, R. A., Canas, P. M., & de Andrade, G. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.045 · Cited by 129 · see citing works
Wenk, G. L., Parsons, C. G., & Danysz, W. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00007 · Cited by 128 · see citing works
The Role of Astrocytes in the Neurorepair Process
Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 126 · see citing works
Harnessing the anti-inflammatory potential of palmitoylethanolamide
Alhouayek, M., & Muccioli, G. G. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.06.007 · Cited by 122 · see citing works
Astrocytes facilitate melanoma brain metastasis via secretion of IL ‐23
Klein, A., Doron, H., Sagi‐Assif, O., Meshel, T., Izraely, S., Ben‐Menachem, S., Bengaiev, R., Ben‐Shmuel, A., Nahmias, C., Couraud, P., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4509 · Cited by 121 · see citing works
Hashemzadeh, H., Javadi, H., & Darvishi, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-58730-z · Cited by 120 · see citing works
Tansey, M. G. (2007) · Frontiers in bioscience · doi:10.2741/2713 · Cited by 120 · see citing works
Roles of P2 receptors in glial cells: focus on astrocytes
Abbracchio, M. P., & Ceruti, S. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9016-0 · Cited by 116 · see citing works
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Doron, H., Blacher, E., Amer, M., Livneh, N., Abramovitz, L., Klein, A., Ben‐Shushan, D., Soffer, S., Blazquez, R., Barrantes‐Freer, A., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0485 · Cited by 107 · see citing works
Hinault, M., Ben‐Zvi, A., & Goloubinoff, P. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:30:3:249 · Cited by 105 · see citing works
Mathieu, P., Battista, D., Depino, A. M., Roca, V., Graciarena, M., & Pitossi, F. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06548.x · Cited by 104 · see citing works
Tapia‐González, S., Carrero, P., Pernía, O., García‐Segura, L. M., & Diz-Chaves, Y. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0294 · Cited by 101 · see citing works
Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease
Leggio, L., Paternò, G., Vivarelli, S., L’Episcopo, F., Tirolo, C., Raciti, G., Pappalardo, F., Giachino, C., Caniglia, S., Serapide, M. F., et al. (2020) · Biomolecules · doi:10.3390/biom10091327 · Cited by 100 · see citing works
Self-citationSelective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells
Arévalo, M., Diz-Chaves, Y., Santos‐Galindo, M., Bellini, M. J., & García‐Segura, L. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02156.x · Cited by 98 · see citing works
Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol
Fujii, H., Sun, B., Nishioka, H., Aya, H., & Aruoma, O. I. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.08.026 · Cited by 98 · see citing works
L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Impagnatiello, F., Pluchino, S., & Marchetti, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3206-12.2013 · Cited by 94 · see citing works
Self-citationUracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation
Lecca, D., & Ceruti, S. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.12.009 · Cited by 92 · see citing works
Nadler, Y., Alexandrovich, A. G., Grigoriadis, N., Hartmann, T., Rao, K. S. J., Shohami, E., & Stein, R. (2008) · Glia · doi:10.1002/glia.20638 · Cited by 93 · see citing works
Marchetti, B., L’Episcopo, F., Morale, M. C., Tirolo, C., Testa, N., Caniglia, S., Serapide, M. F., & Pluchino, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12166 · Cited by 91 · see citing works
Self-citationHernández-Romero, M. C., Delgado-Cortés, M. J., Sarmiento, M., de Pablos, R. M., Espinosa-Oliva, A. M., Argüelles, S., Bández, M. J., Villarán, R. F., Mauriño, R., Santiago, M., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.01.018 · Cited by 100 · see citing works
Aruoma, O. I., Sun, B., Fujii, H., Neergheen, V. S., Bahorun, T., Kang, K., & Sung, M. (2006) · BioFactors · doi:10.1002/biof.5520270121 · Cited by 89 · see citing works
Annexin A1 in the brain – undiscovered roles?
Solito, E., McArthur, S., Christian, H., Gavins, F. N. E., Buckingham, J. C., & Gillies, G. E. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.12.003 · Cited by 86 · see citing works
L’Episcopo, F., Tirolo, C., Serapide, M. F., Caniglia, S., Testa, N., Leggio, L., Vivarelli, S., Iraci, N., Pluchino, S., & Marchetti, B. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00012 · Cited by 84 · see citing works
Self-citationIsmaiel, A. A., Espinosa‐Oliva, A. M., Santiago, M., García-Quintanilla, A., Oliva-Martín, M. J., Herrera, A. J., Venero, J. L., & de Pablos, R. M. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.03.004 · Cited by 81 · see citing works
L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Morale, M. C., Serapide, M. F., Pluchino, S., & Marchetti, B. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt053 · Cited by 80 · see citing works
Self-citationSerafino, A., Giovannini, D., Rossi, S., & Cozzolino, M. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1746266 · Cited by 78 · see citing works
Henríquez, G., Gomez, A., Guerrero, E., & Narayan, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00381 · Cited by 83 · see citing works
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Saeed, F., Arshad, M. U., Pasha, I., Naz, R., Batool, R., Khan, A. A., Nasir, M. A., & Shafique, B. (2013) · International Journal of Food Properties · doi:10.1080/10942912.2012.709210 · Cited by 75 · see citing works
Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2
Xu, Q., Xu, W., Cheng, H., Yuan, H., & Tan, X. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.07.004 · Cited by 75 · see citing works
The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration
Saravi, S. S. S., Saravi, S. S. S., Arefidoust, A., & Dehpour, A. R. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0021-5 · Cited by 75 · see citing works
Franke, H., Parravicini, C., Lecca, D., Zanier, E. R., Heine, C., Bremicker, K., Fumagalli, M., Rosa, P., Longhi, L. G., Stocchetti, N., et al. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9366-3 · Cited by 71 · see citing works
Self-citationSelective estrogen receptor modulators regulate reactive microglia after penetrating brain injury
Barreto, G. E., Santos‐Galindo, M., & García‐Segura, L. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00132 · Cited by 71 · see citing works
Applications and bioefficacy of the functional food supplement fermented papaya preparation
Aruoma, O. I., Hayashi, Y., Marotta, F., Mantello, P., Rachmilewitz, E. A., & Montagnier, L. (2010) · Toxicology · doi:10.1016/j.tox.2010.09.006 · Cited by 71 · see citing works
Kartikasari, A. E. R., Georgiou, N., Visseren, F. L. J., Kats-Renaud, H. J. V., van Asbeck, B. S., & Marx, J. J. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4700fje · Cited by 69 · see citing works
Abrogated Inflammatory Response Promotes Neurogenesis in a Murine Model of Japanese Encephalitis
Das, S., Dutta, K., Kumawat, K. L., Ghoshal, A., Adhya, D., & Basu, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017225 · Cited by 71 · see citing works
P1 receptors and cytokine secretion
Abbracchio, M. P., & Ceruti, S. (2007) · Purinergic Signalling · doi:10.1007/s11302-006-9033-z · Cited by 70 · see citing works
Self-citationPattarini, R., Smeyne, R. J., & Morgan, J. I. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.030 · Cited by 70 · see citing works
Aruoma, O. I., Colognato, R., Fontana, I., Gartlon, J., Migliore, L., Koike, K., Coecke, S., Lamy, E., Mersch‐Sundermann, V., Laurenza, I., et al. (2006) · BioFactors · doi:10.1002/biof.5520260205 · Cited by 69 · see citing works
Lahaie-Collins, V., Bournival, J., Plouffe, M., Carange, J., & Martinoli, M. (2008) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.1.1.6958 · Cited by 65 · see citing works
de Souza, D. F., Leite, M. C., Quincozes‐Santos, A., Nardin, P., Tortorelli, L. S., Rigo, M., Gottfried, C., Leal, R. B., & Gonçalves, C. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.10.012 · Cited by 65 · see citing works
Bel, E. A. D., Bortolanza, M., Pereira, M. D. S., Bariotto‐dos‐Santos, K., & Raisman‐Vozari, R. (2016) · Synapse · doi:10.1002/syn.21941 · Cited by 65 · see citing works
Zhou, J., Qu, X., Li, Z., Wei-Ji, Liu, Q., Ma, Y., & He, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101668 · Cited by 62 · see citing works
Coppolino, G., Marangon, D., Negri, C., Menichetti, G., Fumagalli, M., Gelosa, P., Dimou, L., Furlan, R., Lecca, D., & Abbracchio, M. P. (2018) · Glia · doi:10.1002/glia.23305 · Cited by 60 · see citing works
Self-citationL’Episcopo, F., Tirolo, C., Peruzzotti‐Jametti, L., Serapide, M. F., Testa, N., Caniglia, S., Balzarotti, B., Pluchino, S., & Marchetti, B. (2018) · Stem Cells · doi:10.1002/stem.2827 · Cited by 59 · see citing works
Self-citationL’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Serra, P. A., Impagnatiello, F., Morale, M. C., & Marchetti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-83 · Cited by 59 · see citing works
Self-citationDeath in the substantia nigra: a motor tragedy
Esposito, E., Matteo, V. D., & Giovanni, G. D. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.6.677 · Cited by 59 · see citing works
Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?
Morale, M. C., L’Episcopo, F., Tirolo, C., Giaquinta, G., Caniglia, S., Testa, N., Arcieri, P., Serra, P. A., Lupo, G., Alberghina, M., et al. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.011 · Cited by 59 · see citing works
Self-citationChen, W.-F., Chakraborty, C., Sung, C., Feng, C., Jean, Y., Lin, Y., Hung, H.-C., Huang, T.-Y., Huang, S., Su, T.-M., et al. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0710-2 · Cited by 57 · see citing works
Translocator protein (18 kDa) is involved in the regulation of reactive gliosis
Veiga, S., Carrero, P., Pernia, O., Azcoitia, I., & Garcia‐Segura, L. M. (2007) · Glia · doi:10.1002/glia.20558 · Cited by 62 · see citing works
Monaco, A., Ferrandino, I., Boscaino, F., Cocca, E., Cigliano, L., Maurano, F., Luongo, D., Spagnuolo, M. S., Rossi, M., & Bergamo, P. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m079400 · Cited by 56 · see citing works
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease
Leggio, L., Paternò, G., Vivarelli, S., Falzone, G. G., Giachino, C., Marchetti, B., & Iraci, N. (2021) · Aging and disease · doi:10.14336/ad.2021.0527 · Cited by 55 · see citing works
Self-citationNeurodegeneration and Neuroinflammation in cdk5/p25-Inducible Mice
Muyllaert, D., Terwel, D., Kremer, A., Sennvik, K., Borghgraef, P., Devijver, H., Dewachter, I., & LEUVEN, F. V. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070693 · Cited by 55 · see citing works
Simões, A. P., Duarte, J. A., Agasse, F., Canas, P. M., Tomé, Â. R., Agostinho, P. M., & Cunha, R. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-204 · Cited by 54 · see citing works
Neurodegeneration and cell replacement
Ormerod, B. K., Palmer, T. D., & Caldwell, M. A. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.2018 · Cited by 52 · see citing works
Leggio, L., L'Episcopo, F., Magrì, A., Ulloa‐Navas, M. J., Paternò, G., Vivarelli, S., Bastos, C. A. P., Tirolo, C., Testa, N., Caniglia, S., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201203 · Cited by 54 · see citing works
Self-citationThe Neuroprotective Effect of Fisetin in the MPTP Model of Parkinson's Disease
Patel, M. Y., Panchal, H., Ghribi, O., & Benzeroual, K. E. (2012) · Journal of Parkinson s Disease · doi:10.3233/jpd-012110 · Cited by 51 · see citing works
Iravani, M. M., Sadeghian, M., Leung, C. C. M., Jenner, P. G., & Rose, S. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.022 · Cited by 51 · see citing works
Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease
Marchetti, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101664 · Cited by 49 · see citing works
Self-citation
- Authors
- Marchetti, B., & Abbracchio, M. P.
- Affiliations
- University of Sassari (IT)
- University of Milan (IT)
- Corresponding author
- Marchetti, Bianca
- Abbracchio, Maria P.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 26
- Issue
- 10
- Pages
- 517-525
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2017364016
- Cited by
- 175
- References
- 74
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (189)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- neuroinflammation, neurodegenerative diseases, anti-inflammatory agents, nonsteroidal anti-inflammatory drugs, Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, microglia, neuroprotection, innate immune response, adaptive immune response, immunomodulation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Encephalitis, Humans, Immunity, Innate, Neurodegenerative Diseases
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