Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.
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The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with mitochondria whereby the contact is referred to as the mitochondrion-associated ER membrane or the MAM. Here we found that the MAM regulates cellular survival via an MAM-residing ER chaperone the sigma-1 receptor (Sig-1R) in that the Sig-1R chaperones the ER stress sensor IRE1 to facilitate inter-organelle signaling for survival. IRE1 is found in this study to be enriched at the MAM in CHO cells. We found that IRE1 is stabilized at the MAM by Sig-1Rs when cells are under ER stress. Sig-1Rs stabilize IRE1 and thus allow for conformationally correct IRE1 to dimerize into the long-lasting, activated endonuclease. The IRE1 at the MAM also responds to reactive oxygen species derived from mitochondria. Therefore, the ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.
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Inside the cell, Sig-1R is located mainly at the ER-mitochondrion interface (MAM) and regulates cellular bioenergetics, particularly under stressful conditions.
“Inside the cell Sig-1R is located mainly at the ER–mitochondrion interface—referred to as the MAM—and regulates cellular bioenergetics, particularly under stressful conditions (Su et al., 2010; Mori et al., 2013; Hayashi, 2015).”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Mori et al., 2013
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Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
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Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders
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- Authors
- Mori, T., Hayashi, T., Hayashi, E., & Su, T.-P.
- Affiliations
- United States Department of Health and Human Services (US)
- Corresponding author
- Su, Tsung-Ping
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-10-18
- Volume
- 8
- Issue
- 10
- Pages
- e76941
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3799859
- OpenAlex
- W1994289493
- Cited by
- 317
- References
- 51
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 20 · 2023: 29 · 2022: 26 · 2021: 38 · 2020: 33 · 2019: 34 · 2018: 18 · 2017: 29 · 2016: 16 · 2015: 10 · 2014: 17
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute on Drug Abuse
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- sigma-1 receptor, mitochondria-associated membranes, endoplasmic reticulum, IRE1, endoplasmic reticulum stress, mitochondrial reactive oxygen species, molecular chaperones, protein stabilization, endonuclease activation, cell survival
- MeSH terms
- Sigma-1 Receptor, Animals, Cell Nucleus, Cell Survival, Cricetulus, Endoplasmic Reticulum, Endoribonucleases, Cricetinae, HeLa Cells, Humans, Immunohistochemistry, Intracellular Membranes, Mitochondria, Mutation, Protein Binding, Blotting, Western, Signal Transduction, CHO Cells, Protein Serine-Threonine Kinases, Reactive Oxygen Species, Receptors, sigma, Microscopy, Confocal, Molecular Chaperones, RNA Interference, Cell Line, Tumor, Mice
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